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Bivalent polyether ionophores : Synthesis and biological evaluation of C2-symmetric salinomycin dimers

Antoszczak, Michał; Maj, Ewa; Borgström, Björn LU ; Oredsson, Stina LU ; Huczyński, Adam; Wietrzyk, Joanna and Strand, Daniel LU (2017) In Tetrahedron Letters 58(24). p.2396-2399
Abstract

Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-proliferative activity, Glaser-type coupling reaction, Ionophore antibiotics, Multivalent structures, SRB assay
in
Tetrahedron Letters
volume
58
issue
24
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:85019603950
  • wos:000403528100022
ISSN
0040-4039
DOI
10.1016/j.tetlet.2017.05.023
language
English
LU publication?
yes
id
65001191-b85f-4696-84fe-5ca009fd10e1
date added to LUP
2017-06-13 11:41:45
date last changed
2018-03-04 05:02:39
@article{65001191-b85f-4696-84fe-5ca009fd10e1,
  abstract     = {<p>Efficient methods for the synthesis of C<sub>2</sub>-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.</p>},
  author       = {Antoszczak, Michał and Maj, Ewa and Borgström, Björn and Oredsson, Stina and Huczyński, Adam and Wietrzyk, Joanna and Strand, Daniel},
  issn         = {0040-4039},
  keyword      = {Anti-proliferative activity,Glaser-type coupling reaction,Ionophore antibiotics,Multivalent structures,SRB assay},
  language     = {eng},
  number       = {24},
  pages        = {2396--2399},
  publisher    = {Elsevier},
  series       = {Tetrahedron Letters},
  title        = {Bivalent polyether ionophores : Synthesis and biological evaluation of C<sub>2</sub>-symmetric salinomycin dimers},
  url          = {http://dx.doi.org/10.1016/j.tetlet.2017.05.023},
  volume       = {58},
  year         = {2017},
}