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Bivalent polyether ionophores : Synthesis and biological evaluation of C2-symmetric salinomycin dimers

Antoszczak, Michał ; Maj, Ewa ; Borgström, Björn LU ; Oredsson, Stina LU ; Huczyński, Adam ; Wietrzyk, Joanna and Strand, Daniel LU (2017) In Tetrahedron Letters 58(24). p.2396-2399
Abstract

Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-proliferative activity, Glaser-type coupling reaction, Ionophore antibiotics, Multivalent structures, SRB assay
in
Tetrahedron Letters
volume
58
issue
24
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:85019603950
  • wos:000403528100022
ISSN
0040-4039
DOI
10.1016/j.tetlet.2017.05.023
language
English
LU publication?
yes
id
65001191-b85f-4696-84fe-5ca009fd10e1
date added to LUP
2017-06-13 11:41:45
date last changed
2024-06-09 18:15:13
@article{65001191-b85f-4696-84fe-5ca009fd10e1,
  abstract     = {{<p>Efficient methods for the synthesis of C<sub>2</sub>-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.</p>}},
  author       = {{Antoszczak, Michał and Maj, Ewa and Borgström, Björn and Oredsson, Stina and Huczyński, Adam and Wietrzyk, Joanna and Strand, Daniel}},
  issn         = {{0040-4039}},
  keywords     = {{Anti-proliferative activity; Glaser-type coupling reaction; Ionophore antibiotics; Multivalent structures; SRB assay}},
  language     = {{eng}},
  number       = {{24}},
  pages        = {{2396--2399}},
  publisher    = {{Elsevier}},
  series       = {{Tetrahedron Letters}},
  title        = {{Bivalent polyether ionophores : Synthesis and biological evaluation of C<sub>2</sub>-symmetric salinomycin dimers}},
  url          = {{http://dx.doi.org/10.1016/j.tetlet.2017.05.023}},
  doi          = {{10.1016/j.tetlet.2017.05.023}},
  volume       = {{58}},
  year         = {{2017}},
}