Bivalent polyether ionophores : Synthesis and biological evaluation of C2-symmetric salinomycin dimers
(2017) In Tetrahedron Letters 58(24). p.2396-2399- Abstract
Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/65001191-b85f-4696-84fe-5ca009fd10e1
- author
- Antoszczak, Michał ; Maj, Ewa ; Borgström, Björn LU ; Oredsson, Stina LU ; Huczyński, Adam ; Wietrzyk, Joanna and Strand, Daniel LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anti-proliferative activity, Glaser-type coupling reaction, Ionophore antibiotics, Multivalent structures, SRB assay
- in
- Tetrahedron Letters
- volume
- 58
- issue
- 24
- pages
- 4 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85019603950
- wos:000403528100022
- ISSN
- 0040-4039
- DOI
- 10.1016/j.tetlet.2017.05.023
- language
- English
- LU publication?
- yes
- id
- 65001191-b85f-4696-84fe-5ca009fd10e1
- date added to LUP
- 2017-06-13 11:41:45
- date last changed
- 2024-06-09 18:15:13
@article{65001191-b85f-4696-84fe-5ca009fd10e1, abstract = {{<p>Efficient methods for the synthesis of C<sub>2</sub>-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.</p>}}, author = {{Antoszczak, Michał and Maj, Ewa and Borgström, Björn and Oredsson, Stina and Huczyński, Adam and Wietrzyk, Joanna and Strand, Daniel}}, issn = {{0040-4039}}, keywords = {{Anti-proliferative activity; Glaser-type coupling reaction; Ionophore antibiotics; Multivalent structures; SRB assay}}, language = {{eng}}, number = {{24}}, pages = {{2396--2399}}, publisher = {{Elsevier}}, series = {{Tetrahedron Letters}}, title = {{Bivalent polyether ionophores : Synthesis and biological evaluation of C<sub>2</sub>-symmetric salinomycin dimers}}, url = {{http://dx.doi.org/10.1016/j.tetlet.2017.05.023}}, doi = {{10.1016/j.tetlet.2017.05.023}}, volume = {{58}}, year = {{2017}}, }