Hollow-fibre supported liquid membrane extraction for determination of fluoxetine and norfluoxetine concentration at ultra trace level in sewage samples
(2007) In Journal of Separation Science 30(15). p.2513-2521- Abstract
- In this study, a method was developed for determining the concentration of the pharmaceutical fluoxetine and its metabolite, norfluoxetine, in sewage water samples. Sample preparation was performed by hollow-fibre supported liquid membrane (HF-SLM) extraction with final analysis using liquid chromatography with UV detection. Several parameters were studied including type of organic solvent, sample and acceptor pH, and salt and humic acid content. The optimised method allowed determination of the analyte at the ng/L level in sewage water. A linear plot gave a correlation coefficient better than 0.991 for both analytes and resulted in limits of detection in sewage water of 11 and 12 ng/L, for fluoxetine and norfluoxetine, respectively. The... (More)
- In this study, a method was developed for determining the concentration of the pharmaceutical fluoxetine and its metabolite, norfluoxetine, in sewage water samples. Sample preparation was performed by hollow-fibre supported liquid membrane (HF-SLM) extraction with final analysis using liquid chromatography with UV detection. Several parameters were studied including type of organic solvent, sample and acceptor pH, and salt and humic acid content. The optimised method allowed determination of the analyte at the ng/L level in sewage water. A linear plot gave a correlation coefficient better than 0.991 for both analytes and resulted in limits of detection in sewage water of 11 and 12 ng/L, for fluoxetine and norfluoxetine, respectively. The enrichment factor was over 1700 for both analytes in sewage water. The repeatability and reproducibility were better than 8% and 17%, respectively. The developed methodology was used to study daily variations of fluoxetine and norfluoxetine in municipal sewage streams. Norfluoxetine has been detected for the first time in sewage water and a preliminary analysis gave average concentrations of 150 and 225 ng/L for norfluoxetine and fluoxetine, respectively. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/653071
- author
- Zorita, Saioa LU ; Martensson, Lennart and Mathiasson, Lennart LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- supported liquid, occurrence in sewage, norfluoxetine, fluoxetine, hollow-fibre, membrane extraction
- in
- Journal of Separation Science
- volume
- 30
- issue
- 15
- pages
- 2513 - 2521
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000250454100022
- scopus:35649006015
- pmid:17763523
- ISSN
- 1615-9314
- DOI
- 10.1002/jssc.200700165
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)
- id
- 3d2afe9d-5c73-4305-bf14-6a83241d380e (old id 653071)
- date added to LUP
- 2016-04-01 11:42:42
- date last changed
- 2022-01-26 17:06:29
@article{3d2afe9d-5c73-4305-bf14-6a83241d380e, abstract = {{In this study, a method was developed for determining the concentration of the pharmaceutical fluoxetine and its metabolite, norfluoxetine, in sewage water samples. Sample preparation was performed by hollow-fibre supported liquid membrane (HF-SLM) extraction with final analysis using liquid chromatography with UV detection. Several parameters were studied including type of organic solvent, sample and acceptor pH, and salt and humic acid content. The optimised method allowed determination of the analyte at the ng/L level in sewage water. A linear plot gave a correlation coefficient better than 0.991 for both analytes and resulted in limits of detection in sewage water of 11 and 12 ng/L, for fluoxetine and norfluoxetine, respectively. The enrichment factor was over 1700 for both analytes in sewage water. The repeatability and reproducibility were better than 8% and 17%, respectively. The developed methodology was used to study daily variations of fluoxetine and norfluoxetine in municipal sewage streams. Norfluoxetine has been detected for the first time in sewage water and a preliminary analysis gave average concentrations of 150 and 225 ng/L for norfluoxetine and fluoxetine, respectively.}}, author = {{Zorita, Saioa and Martensson, Lennart and Mathiasson, Lennart}}, issn = {{1615-9314}}, keywords = {{supported liquid; occurrence in sewage; norfluoxetine; fluoxetine; hollow-fibre; membrane extraction}}, language = {{eng}}, number = {{15}}, pages = {{2513--2521}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Separation Science}}, title = {{Hollow-fibre supported liquid membrane extraction for determination of fluoxetine and norfluoxetine concentration at ultra trace level in sewage samples}}, url = {{http://dx.doi.org/10.1002/jssc.200700165}}, doi = {{10.1002/jssc.200700165}}, volume = {{30}}, year = {{2007}}, }