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Sphingomyelinase and ceramidase in the intestinal tract

Duan, Rui-Dong LU (2007) In European Journal of Lipid Science and Technology 109(10). p.987-993
Abstract
Sphingomyelin (SM) has emerged as an important source of lipid messengers affecting cell proliferation, differentiation and apoptosis. SM is present in mammalian cell membranes as a lipid constituent and also found as a component of dietary products such as milk, egg and meat. Digestion of SM has been found to have important implications in colon cancer development, gut maturation, and cholesterol absorption. SM in the intestine is sequentially digested by alkaline sphingomyelinase and neutral ceramidase before absorption. In the last decade, rapid progress has been made in many aspects of these two enzymes. The review intends to provide a short summary of the current knowledge on the properties, functions and the pathological changes of... (More)
Sphingomyelin (SM) has emerged as an important source of lipid messengers affecting cell proliferation, differentiation and apoptosis. SM is present in mammalian cell membranes as a lipid constituent and also found as a component of dietary products such as milk, egg and meat. Digestion of SM has been found to have important implications in colon cancer development, gut maturation, and cholesterol absorption. SM in the intestine is sequentially digested by alkaline sphingomyelinase and neutral ceramidase before absorption. In the last decade, rapid progress has been made in many aspects of these two enzymes. The review intends to provide a short summary of the current knowledge on the properties, functions and the pathological changes of the enzymes in the intestinal tract. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cholesterol absorption, cancer, intestine, sphingomyelinase, ceramidase
in
European Journal of Lipid Science and Technology
volume
109
issue
10
pages
987 - 993
publisher
John Wiley & Sons
external identifiers
  • wos:000250496800005
  • scopus:35548930265
ISSN
1438-7697
DOI
10.1002/ejlt.200700074
language
English
LU publication?
yes
id
5b4ae15b-b1a8-4e4a-9295-f4c00a5a1153 (old id 653171)
date added to LUP
2007-12-07 13:15:14
date last changed
2017-01-01 05:01:23
@article{5b4ae15b-b1a8-4e4a-9295-f4c00a5a1153,
  abstract     = {Sphingomyelin (SM) has emerged as an important source of lipid messengers affecting cell proliferation, differentiation and apoptosis. SM is present in mammalian cell membranes as a lipid constituent and also found as a component of dietary products such as milk, egg and meat. Digestion of SM has been found to have important implications in colon cancer development, gut maturation, and cholesterol absorption. SM in the intestine is sequentially digested by alkaline sphingomyelinase and neutral ceramidase before absorption. In the last decade, rapid progress has been made in many aspects of these two enzymes. The review intends to provide a short summary of the current knowledge on the properties, functions and the pathological changes of the enzymes in the intestinal tract.},
  author       = {Duan, Rui-Dong},
  issn         = {1438-7697},
  keyword      = {cholesterol absorption,cancer,intestine,sphingomyelinase,ceramidase},
  language     = {eng},
  number       = {10},
  pages        = {987--993},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Lipid Science and Technology},
  title        = {Sphingomyelinase and ceramidase in the intestinal tract},
  url          = {http://dx.doi.org/10.1002/ejlt.200700074},
  volume       = {109},
  year         = {2007},
}