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Macrophage Migration Inhibitory Factor as a Predictor for Long-term Improvements After Mindfulness-Based Group Therapy or Treatment as Usual for Depression, Anxiety or Stress and Adjustment Disorders

Sundquist, Kristina LU ; Palmér, Karolina LU ; Memon, Ashfaque A. LU orcid ; Sundquist, Jan LU and Wang, Xiao LU (2020) In Mindfulness 11(6). p.1370-1377
Abstract

Objectives: Identification of biological markers that can guide treatment selection is considered to be a viable solution for personalized treatment for patients with psychiatric disorders. This study investigated whether macrophage migration inhibitory factor (MIF) levels at baseline were associated with mindfulness-based group therapy or cognitive behavioral therapy response in patients with mild to moderate symptoms of depression, anxiety, or stress- and adjustment disorders. Methods: A total of 168 patients (aged 21–65 years) with psychiatric disorders were included from a randomized controlled trial. Plasma MIF levels in all the patients were analyzed using Luminex assay. Results: Higher MIF levels at baseline were significantly... (More)

Objectives: Identification of biological markers that can guide treatment selection is considered to be a viable solution for personalized treatment for patients with psychiatric disorders. This study investigated whether macrophage migration inhibitory factor (MIF) levels at baseline were associated with mindfulness-based group therapy or cognitive behavioral therapy response in patients with mild to moderate symptoms of depression, anxiety, or stress- and adjustment disorders. Methods: A total of 168 patients (aged 21–65 years) with psychiatric disorders were included from a randomized controlled trial. Plasma MIF levels in all the patients were analyzed using Luminex assay. Results: Higher MIF levels at baseline were significantly associated with better long-term (1-year follow-up) improvement in psychiatric symptoms, as measured by changes in the Montgomery-Åsberg Depression Rating Scale (MADRS-S), compared with lower MIF levels, after adjustment for baseline MADRS-S score, age, sex, BMI, and pharmacotherapy (β = 5.89, p = 0.001). Patients with higher levels of MIF (8235–23,391 pg/ml) had an almost 6 points’ larger decrease in MADRS-S score after 1 year compared with those with lower MIF (727–8223 pg/ml) at baseline. Similar trends were seen after 8 weeks, albeit non-significant (β = 1.99, p = 0.18). Conclusions: The findings indicate that higher plasma MIF levels at baseline may predict better long-term outcomes with psychotherapeutic interventions for mild to moderate symptoms of depression, anxiety, or stress and adjustment disorders. MIF levels may serve as a potential biomarker that can guide treatment selection for the personalized treatment for patients with psychiatric disorders.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anxiety, Cognitive behavioral therapy, Depression, Macrophage migration inhibitory factor, Mindfulness-based therapy
in
Mindfulness
volume
11
issue
6
pages
8 pages
publisher
Springer
external identifiers
  • scopus:85082676443
ISSN
1868-8527
DOI
10.1007/s12671-020-01352-3
language
English
LU publication?
yes
id
6539600a-b75f-4d0b-86d6-227051b66ed8
date added to LUP
2020-04-13 12:53:04
date last changed
2022-04-18 21:56:14
@article{6539600a-b75f-4d0b-86d6-227051b66ed8,
  abstract     = {{<p>Objectives: Identification of biological markers that can guide treatment selection is considered to be a viable solution for personalized treatment for patients with psychiatric disorders. This study investigated whether macrophage migration inhibitory factor (MIF) levels at baseline were associated with mindfulness-based group therapy or cognitive behavioral therapy response in patients with mild to moderate symptoms of depression, anxiety, or stress- and adjustment disorders. Methods: A total of 168 patients (aged 21–65 years) with psychiatric disorders were included from a randomized controlled trial. Plasma MIF levels in all the patients were analyzed using Luminex assay. Results: Higher MIF levels at baseline were significantly associated with better long-term (1-year follow-up) improvement in psychiatric symptoms, as measured by changes in the Montgomery-Åsberg Depression Rating Scale (MADRS-S), compared with lower MIF levels, after adjustment for baseline MADRS-S score, age, sex, BMI, and pharmacotherapy (β = 5.89, p = 0.001). Patients with higher levels of MIF (8235–23,391 pg/ml) had an almost 6 points’ larger decrease in MADRS-S score after 1 year compared with those with lower MIF (727–8223 pg/ml) at baseline. Similar trends were seen after 8 weeks, albeit non-significant (β = 1.99, p = 0.18). Conclusions: The findings indicate that higher plasma MIF levels at baseline may predict better long-term outcomes with psychotherapeutic interventions for mild to moderate symptoms of depression, anxiety, or stress and adjustment disorders. MIF levels may serve as a potential biomarker that can guide treatment selection for the personalized treatment for patients with psychiatric disorders.</p>}},
  author       = {{Sundquist, Kristina and Palmér, Karolina and Memon, Ashfaque A. and Sundquist, Jan and Wang, Xiao}},
  issn         = {{1868-8527}},
  keywords     = {{Anxiety; Cognitive behavioral therapy; Depression; Macrophage migration inhibitory factor; Mindfulness-based therapy}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1370--1377}},
  publisher    = {{Springer}},
  series       = {{Mindfulness}},
  title        = {{Macrophage Migration Inhibitory Factor as a Predictor for Long-term Improvements After Mindfulness-Based Group Therapy or Treatment as Usual for Depression, Anxiety or Stress and Adjustment Disorders}},
  url          = {{http://dx.doi.org/10.1007/s12671-020-01352-3}},
  doi          = {{10.1007/s12671-020-01352-3}},
  volume       = {{11}},
  year         = {{2020}},
}