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Islet cell autoantibody levels after the diagnosis of young adult diabetic patients

Jensen, R.; Gilliam, L.; Törn, Carina LU ; Landin-Olsson, Mona LU ; Palmer, J.; Akesson, K.; Kockum, I.; Lernmark, Barbro LU ; Karlsson, A. F. and Lynch, Kristian LU , et al. (2007) In Diabetic Medicine 24(11). p.1221-1228
Abstract
Aims The aim was to determine the course of islet cell antibodies [glutamate decarboxylase (GADA), tyrosine phosphatase-like islet antigen 2 (IA-2A) and islet cell (ICA)] after the diagnosis of the diabetic patient. Methods The Diabetes Incidence Study in Sweden (DISS) attempted to prospectively enrol all newly diagnosed diabetic patients aged 15-34 years during 1992 and 1993. C-peptide and autoantibody levels were determined from venous blood samples at diagnosis and again at yearly intervals for 6 years. Results After the first year, the odds of remaining GADA positive decreased by 9% per year [odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.85-0.96] while the mean GADA index remained unchanged (chi(2)(1) = 0.8, P = 0.37). There... (More)
Aims The aim was to determine the course of islet cell antibodies [glutamate decarboxylase (GADA), tyrosine phosphatase-like islet antigen 2 (IA-2A) and islet cell (ICA)] after the diagnosis of the diabetic patient. Methods The Diabetes Incidence Study in Sweden (DISS) attempted to prospectively enrol all newly diagnosed diabetic patients aged 15-34 years during 1992 and 1993. C-peptide and autoantibody levels were determined from venous blood samples at diagnosis and again at yearly intervals for 6 years. Results After the first year, the odds of remaining GADA positive decreased by 9% per year [odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.85-0.96] while the mean GADA index remained unchanged (chi(2)(1) = 0.8, P = 0.37). There was no change in the percentage of subjects testing IA-2A positive after the first year (chi(2)(1) = 0.1, P = 0.75). However, the mean index decreased 0.04 per year (95% CI: 0.03-0.05)-a 7.9% decline (95% CI: 5.4-10.4%). The odds of a subject testing positive for ICA decreased by 24% per year (OR = 0.76, 95% CI = 0.70-0.82). The mean ICA levels decreased 0.75 per year (95% CI: 0.66-0.84)-a 16.4% decline (95% CI: 14.1-18.6%). The rate of change in titres for all three autoantibodies was independent of gender, human leucocyte antigen genotype and C-peptide status. Conclusions GADA levels remained high while ICA levels declined. In contrast to a previous study, we found that the proportion of IA-2A subjects remaining positive did not decrease after the first year, while the average index decreased slightly. (Less)
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publication status
published
subject
keywords
tyrosine phosphatase-like islet antigen 2 antibodies, Type 1 diabetes, islet cell antibodies, C-peptide, glutamate decarboxylase antibodies
in
Diabetic Medicine
volume
24
issue
11
pages
1221 - 1228
publisher
Wiley-Blackwell
external identifiers
  • wos:000250297500007
  • scopus:35449003333
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2007.02235.x
language
English
LU publication?
yes
id
f6121f08-fabe-4345-928b-6c495f15f811 (old id 654120)
date added to LUP
2007-12-13 10:43:12
date last changed
2017-08-20 04:27:56
@article{f6121f08-fabe-4345-928b-6c495f15f811,
  abstract     = {Aims The aim was to determine the course of islet cell antibodies [glutamate decarboxylase (GADA), tyrosine phosphatase-like islet antigen 2 (IA-2A) and islet cell (ICA)] after the diagnosis of the diabetic patient. Methods The Diabetes Incidence Study in Sweden (DISS) attempted to prospectively enrol all newly diagnosed diabetic patients aged 15-34 years during 1992 and 1993. C-peptide and autoantibody levels were determined from venous blood samples at diagnosis and again at yearly intervals for 6 years. Results After the first year, the odds of remaining GADA positive decreased by 9% per year [odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.85-0.96] while the mean GADA index remained unchanged (chi(2)(1) = 0.8, P = 0.37). There was no change in the percentage of subjects testing IA-2A positive after the first year (chi(2)(1) = 0.1, P = 0.75). However, the mean index decreased 0.04 per year (95% CI: 0.03-0.05)-a 7.9% decline (95% CI: 5.4-10.4%). The odds of a subject testing positive for ICA decreased by 24% per year (OR = 0.76, 95% CI = 0.70-0.82). The mean ICA levels decreased 0.75 per year (95% CI: 0.66-0.84)-a 16.4% decline (95% CI: 14.1-18.6%). The rate of change in titres for all three autoantibodies was independent of gender, human leucocyte antigen genotype and C-peptide status. Conclusions GADA levels remained high while ICA levels declined. In contrast to a previous study, we found that the proportion of IA-2A subjects remaining positive did not decrease after the first year, while the average index decreased slightly.},
  author       = {Jensen, R. and Gilliam, L. and Törn, Carina and Landin-Olsson, Mona and Palmer, J. and Akesson, K. and Kockum, I. and Lernmark, Barbro and Karlsson, A. F. and Lynch, Kristian and Breslow, N. and Lernmark, Åke and Sundkvist, Göran},
  issn         = {1464-5491},
  keyword      = {tyrosine phosphatase-like islet antigen 2 antibodies,Type 1 diabetes,islet cell antibodies,C-peptide,glutamate decarboxylase antibodies},
  language     = {eng},
  number       = {11},
  pages        = {1221--1228},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Islet cell autoantibody levels after the diagnosis of young adult diabetic patients},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2007.02235.x},
  volume       = {24},
  year         = {2007},
}