Islet cell autoantibody levels after the diagnosis of young adult diabetic patients
(2007) In Diabetic Medicine 24(11). p.1221-1228- Abstract
- Aims The aim was to determine the course of islet cell antibodies [glutamate decarboxylase (GADA), tyrosine phosphatase-like islet antigen 2 (IA-2A) and islet cell (ICA)] after the diagnosis of the diabetic patient. Methods The Diabetes Incidence Study in Sweden (DISS) attempted to prospectively enrol all newly diagnosed diabetic patients aged 15-34 years during 1992 and 1993. C-peptide and autoantibody levels were determined from venous blood samples at diagnosis and again at yearly intervals for 6 years. Results After the first year, the odds of remaining GADA positive decreased by 9% per year [odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.85-0.96] while the mean GADA index remained unchanged (chi(2)(1) = 0.8, P = 0.37). There... (More)
- Aims The aim was to determine the course of islet cell antibodies [glutamate decarboxylase (GADA), tyrosine phosphatase-like islet antigen 2 (IA-2A) and islet cell (ICA)] after the diagnosis of the diabetic patient. Methods The Diabetes Incidence Study in Sweden (DISS) attempted to prospectively enrol all newly diagnosed diabetic patients aged 15-34 years during 1992 and 1993. C-peptide and autoantibody levels were determined from venous blood samples at diagnosis and again at yearly intervals for 6 years. Results After the first year, the odds of remaining GADA positive decreased by 9% per year [odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.85-0.96] while the mean GADA index remained unchanged (chi(2)(1) = 0.8, P = 0.37). There was no change in the percentage of subjects testing IA-2A positive after the first year (chi(2)(1) = 0.1, P = 0.75). However, the mean index decreased 0.04 per year (95% CI: 0.03-0.05)-a 7.9% decline (95% CI: 5.4-10.4%). The odds of a subject testing positive for ICA decreased by 24% per year (OR = 0.76, 95% CI = 0.70-0.82). The mean ICA levels decreased 0.75 per year (95% CI: 0.66-0.84)-a 16.4% decline (95% CI: 14.1-18.6%). The rate of change in titres for all three autoantibodies was independent of gender, human leucocyte antigen genotype and C-peptide status. Conclusions GADA levels remained high while ICA levels declined. In contrast to a previous study, we found that the proportion of IA-2A subjects remaining positive did not decrease after the first year, while the average index decreased slightly. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/654120
- author
- Jensen, R.
; Gilliam, L.
; Törn, Carina
LU
; Landin-Olsson, Mona
LU
; Palmer, J.
; Akesson, K.
; Kockum, I.
; Lernmark, Barbro
LU
; Karlsson, A. F.
; Lynch, Kristian
LU
; Breslow, N.
; Lernmark, Åke
LU
and Sundkvist, Göran
LU
(Less) - organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tyrosine phosphatase-like islet antigen 2 antibodies, Type 1 diabetes, islet cell antibodies, C-peptide, glutamate decarboxylase antibodies
- in
- Diabetic Medicine
- volume
- 24
- issue
- 11
- pages
- 1221 - 1228
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000250297500007
- scopus:35449003333
- pmid:17725633
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2007.02235.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes and Celiac Unit (013241540), Medicine (Lund) (013230025), Diabetes Epidemiology and Neuropathy (013241560)
- id
- f6121f08-fabe-4345-928b-6c495f15f811 (old id 654120)
- date added to LUP
- 2016-04-01 16:37:32
- date last changed
- 2024-01-11 11:38:16
@article{f6121f08-fabe-4345-928b-6c495f15f811,
abstract = {{Aims The aim was to determine the course of islet cell antibodies [glutamate decarboxylase (GADA), tyrosine phosphatase-like islet antigen 2 (IA-2A) and islet cell (ICA)] after the diagnosis of the diabetic patient. Methods The Diabetes Incidence Study in Sweden (DISS) attempted to prospectively enrol all newly diagnosed diabetic patients aged 15-34 years during 1992 and 1993. C-peptide and autoantibody levels were determined from venous blood samples at diagnosis and again at yearly intervals for 6 years. Results After the first year, the odds of remaining GADA positive decreased by 9% per year [odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.85-0.96] while the mean GADA index remained unchanged (chi(2)(1) = 0.8, P = 0.37). There was no change in the percentage of subjects testing IA-2A positive after the first year (chi(2)(1) = 0.1, P = 0.75). However, the mean index decreased 0.04 per year (95% CI: 0.03-0.05)-a 7.9% decline (95% CI: 5.4-10.4%). The odds of a subject testing positive for ICA decreased by 24% per year (OR = 0.76, 95% CI = 0.70-0.82). The mean ICA levels decreased 0.75 per year (95% CI: 0.66-0.84)-a 16.4% decline (95% CI: 14.1-18.6%). The rate of change in titres for all three autoantibodies was independent of gender, human leucocyte antigen genotype and C-peptide status. Conclusions GADA levels remained high while ICA levels declined. In contrast to a previous study, we found that the proportion of IA-2A subjects remaining positive did not decrease after the first year, while the average index decreased slightly.}},
author = {{Jensen, R. and Gilliam, L. and Törn, Carina and Landin-Olsson, Mona and Palmer, J. and Akesson, K. and Kockum, I. and Lernmark, Barbro and Karlsson, A. F. and Lynch, Kristian and Breslow, N. and Lernmark, Åke and Sundkvist, Göran}},
issn = {{1464-5491}},
keywords = {{tyrosine phosphatase-like islet antigen 2 antibodies; Type 1 diabetes; islet cell antibodies; C-peptide; glutamate decarboxylase antibodies}},
language = {{eng}},
number = {{11}},
pages = {{1221--1228}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine}},
title = {{Islet cell autoantibody levels after the diagnosis of young adult diabetic patients}},
url = {{http://dx.doi.org/10.1111/j.1464-5491.2007.02235.x}},
doi = {{10.1111/j.1464-5491.2007.02235.x}},
volume = {{24}},
year = {{2007}},
}