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Involvement of the CD1d-Natural killer T cell pathway in neointima formation after vascular injury

Ström, Åsa LU ; Wigren, Maria LU ; Hultgårdh, Anna LU ; Saxena, Amit LU ; Gomez, Maria LU ; Cardell, Susanna; Nordin Fredrikson, Gunilla LU and Nilsson, Jan LU (2007) In Circulation Research 101(8). p.83-89
Abstract
Recent studies have established that the immune system plays an important role in the development of atherosclerosis. However, its role in regulating the arterial response to mechanical injury is less well studied. Arterial injury is associated with local accumulation of antibodies, and mice lacking functional T and B cells exhibit increased neointima formation, indicating that adaptive immune responses to neoantigens in the damaged tissue modulate the vascular repair process. To study the role of lipid antigen presentation in the arterial response to injury, we analyzed neointima formation in mice deficient in the lipid antigen-presenting molecule CD1d using a carotid collar model. As compared with control mice, neointima formation was... (More)
Recent studies have established that the immune system plays an important role in the development of atherosclerosis. However, its role in regulating the arterial response to mechanical injury is less well studied. Arterial injury is associated with local accumulation of antibodies, and mice lacking functional T and B cells exhibit increased neointima formation, indicating that adaptive immune responses to neoantigens in the damaged tissue modulate the vascular repair process. To study the role of lipid antigen presentation in the arterial response to injury, we analyzed neointima formation in mice deficient in the lipid antigen-presenting molecule CD1d using a carotid collar model. As compared with control mice, neointima formation was reduced by >60% (P<0.01) in CD1d(-/-) mice. Moreover, carotid injury of wild-type C57BL/6 mice was associated with expansion of CD1d-restricted natural killer T cells in the spleen and accumulation of natural killer T cells in the periadventitial space of injured arteries. The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arterial injury, antigen presentation, neointima
in
Circulation Research
volume
101
issue
8
pages
83 - 89
publisher
American Heart Association
external identifiers
  • wos:000250097800016
  • scopus:35448984559
ISSN
0009-7330
DOI
10.1161/CIRCRESAHA.107.160705
language
English
LU publication?
yes
id
58b1c6e0-b5c7-4081-bba7-97fa8f343129 (old id 654147)
date added to LUP
2007-12-18 14:33:51
date last changed
2017-11-12 03:59:08
@article{58b1c6e0-b5c7-4081-bba7-97fa8f343129,
  abstract     = {Recent studies have established that the immune system plays an important role in the development of atherosclerosis. However, its role in regulating the arterial response to mechanical injury is less well studied. Arterial injury is associated with local accumulation of antibodies, and mice lacking functional T and B cells exhibit increased neointima formation, indicating that adaptive immune responses to neoantigens in the damaged tissue modulate the vascular repair process. To study the role of lipid antigen presentation in the arterial response to injury, we analyzed neointima formation in mice deficient in the lipid antigen-presenting molecule CD1d using a carotid collar model. As compared with control mice, neointima formation was reduced by &gt;60% (P&lt;0.01) in CD1d(-/-) mice. Moreover, carotid injury of wild-type C57BL/6 mice was associated with expansion of CD1d-restricted natural killer T cells in the spleen and accumulation of natural killer T cells in the periadventitial space of injured arteries. The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses.},
  author       = {Ström, Åsa and Wigren, Maria and Hultgårdh, Anna and Saxena, Amit and Gomez, Maria and Cardell, Susanna and Nordin Fredrikson, Gunilla and Nilsson, Jan},
  issn         = {0009-7330},
  keyword      = {arterial injury,antigen presentation,neointima},
  language     = {eng},
  number       = {8},
  pages        = {83--89},
  publisher    = {American Heart Association},
  series       = {Circulation Research},
  title        = {Involvement of the CD1d-Natural killer T cell pathway in neointima formation after vascular injury},
  url          = {http://dx.doi.org/10.1161/CIRCRESAHA.107.160705},
  volume       = {101},
  year         = {2007},
}