Involvement of the CD1d-Natural killer T cell pathway in neointima formation after vascular injury
(2007) In Circulation Research 101(8). p.83-89- Abstract
- Recent studies have established that the immune system plays an important role in the development of atherosclerosis. However, its role in regulating the arterial response to mechanical injury is less well studied. Arterial injury is associated with local accumulation of antibodies, and mice lacking functional T and B cells exhibit increased neointima formation, indicating that adaptive immune responses to neoantigens in the damaged tissue modulate the vascular repair process. To study the role of lipid antigen presentation in the arterial response to injury, we analyzed neointima formation in mice deficient in the lipid antigen-presenting molecule CD1d using a carotid collar model. As compared with control mice, neointima formation was... (More)
- Recent studies have established that the immune system plays an important role in the development of atherosclerosis. However, its role in regulating the arterial response to mechanical injury is less well studied. Arterial injury is associated with local accumulation of antibodies, and mice lacking functional T and B cells exhibit increased neointima formation, indicating that adaptive immune responses to neoantigens in the damaged tissue modulate the vascular repair process. To study the role of lipid antigen presentation in the arterial response to injury, we analyzed neointima formation in mice deficient in the lipid antigen-presenting molecule CD1d using a carotid collar model. As compared with control mice, neointima formation was reduced by >60% (P<0.01) in CD1d(-/-) mice. Moreover, carotid injury of wild-type C57BL/6 mice was associated with expansion of CD1d-restricted natural killer T cells in the spleen and accumulation of natural killer T cells in the periadventitial space of injured arteries. The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/654147
- author
- Ström, Åsa
LU
; Wigren, Maria
LU
; Hultgårdh, Anna
LU
; Saxena, Amit
LU
; Gomez, Maria
LU
; Cardell, Susanna ; Nordin Fredrikson, Gunilla LU and Nilsson, Jan LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- arterial injury, antigen presentation, neointima
- in
- Circulation Research
- volume
- 101
- issue
- 8
- pages
- 83 - 89
- publisher
- American Heart Association
- external identifiers
-
- wos:000250097800016
- scopus:35448984559
- pmid:17885216
- ISSN
- 0009-7330
- DOI
- 10.1161/CIRCRESAHA.107.160705
- language
- English
- LU publication?
- yes
- id
- 58b1c6e0-b5c7-4081-bba7-97fa8f343129 (old id 654147)
- date added to LUP
- 2016-04-01 16:26:24
- date last changed
- 2022-02-20 06:06:07
@article{58b1c6e0-b5c7-4081-bba7-97fa8f343129, abstract = {{Recent studies have established that the immune system plays an important role in the development of atherosclerosis. However, its role in regulating the arterial response to mechanical injury is less well studied. Arterial injury is associated with local accumulation of antibodies, and mice lacking functional T and B cells exhibit increased neointima formation, indicating that adaptive immune responses to neoantigens in the damaged tissue modulate the vascular repair process. To study the role of lipid antigen presentation in the arterial response to injury, we analyzed neointima formation in mice deficient in the lipid antigen-presenting molecule CD1d using a carotid collar model. As compared with control mice, neointima formation was reduced by >60% (P<0.01) in CD1d(-/-) mice. Moreover, carotid injury of wild-type C57BL/6 mice was associated with expansion of CD1d-restricted natural killer T cells in the spleen and accumulation of natural killer T cells in the periadventitial space of injured arteries. The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses.}}, author = {{Ström, Åsa and Wigren, Maria and Hultgårdh, Anna and Saxena, Amit and Gomez, Maria and Cardell, Susanna and Nordin Fredrikson, Gunilla and Nilsson, Jan}}, issn = {{0009-7330}}, keywords = {{arterial injury; antigen presentation; neointima}}, language = {{eng}}, number = {{8}}, pages = {{83--89}}, publisher = {{American Heart Association}}, series = {{Circulation Research}}, title = {{Involvement of the CD1d-Natural killer T cell pathway in neointima formation after vascular injury}}, url = {{http://dx.doi.org/10.1161/CIRCRESAHA.107.160705}}, doi = {{10.1161/CIRCRESAHA.107.160705}}, volume = {{101}}, year = {{2007}}, }