FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
(2007) In Cancer Cell 12(4). p.367-380- Abstract
- Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive... (More)
- Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate. (Less)
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https://lup.lub.lu.se/record/654162
- author
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Cell
- volume
- 12
- issue
- 4
- pages
- 367 - 380
- publisher
- Cell Press
- external identifiers
-
- wos:000250362600010
- scopus:35048848955
- pmid:17936561
- ISSN
- 1878-3686
- DOI
- 10.1016/j.ccr.2007.08.031
- language
- English
- LU publication?
- yes
- id
- d3267e34-3a2c-4baf-9849-3c6b0af601c2 (old id 654162)
- date added to LUP
- 2016-04-01 12:37:03
- date last changed
- 2022-07-22 22:54:50
@article{d3267e34-3a2c-4baf-9849-3c6b0af601c2, abstract = {{Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate.}}, author = {{Lee, Benjamin H. and Tothova, Zuzana and Levine, Ross L. and Anderson, Kristina and Buza-Vidas, Natalija and Cullen, Dana E. and McDowell, Elizabeth P. and Adelsperger, Jennifer and Frhling, Stefan and Huntly, Brian J. P. and Beran, Miloslav and Jacobsen, Sten Eirik W and Gilliland, D. Gary}}, issn = {{1878-3686}}, language = {{eng}}, number = {{4}}, pages = {{367--380}}, publisher = {{Cell Press}}, series = {{Cancer Cell}}, title = {{FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia}}, url = {{http://dx.doi.org/10.1016/j.ccr.2007.08.031}}, doi = {{10.1016/j.ccr.2007.08.031}}, volume = {{12}}, year = {{2007}}, }