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Induction of activating transcription factor 3 after different sciatic nerve injuries in adult rats

Kataoka, Kazuya |; Kanje, Martin LU and Dahlin, Lars LU (2007) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 41(4). p.158-166
Abstract
Staining by activating transcription factor 3 (ATF3), a neuronal marker of nerve injury, was examined by immunocytochemistry in neurons and Schwann cells after crush or transection (regeneration inhibited) of rat sciatic nerve. ATF3 immunoreactivity peaked in neurons after three days and then gradually subsided to normal within 12 weeks after the crush. The response lasted somewhat longer and declined over time in spinal cord neurons but not in those of dorsal root ganglia (DRG) after transection, indicating a differential regulation of sensory and motor neurons. ATF3 expression was more pronounced in Schwann cells, and remained longer after transection, implying that to some extent regenerating axons produce signals that reduce ATF3... (More)
Staining by activating transcription factor 3 (ATF3), a neuronal marker of nerve injury, was examined by immunocytochemistry in neurons and Schwann cells after crush or transection (regeneration inhibited) of rat sciatic nerve. ATF3 immunoreactivity peaked in neurons after three days and then gradually subsided to normal within 12 weeks after the crush. The response lasted somewhat longer and declined over time in spinal cord neurons but not in those of dorsal root ganglia (DRG) after transection, indicating a differential regulation of sensory and motor neurons. ATF3 expression was more pronounced in Schwann cells, and remained longer after transection, implying that to some extent regenerating axons produce signals that reduce ATF3 expression in Schwann cells. However, even after transection without repair (no contact with regenerating axons), ATF3 expression in Schwann cells in the distal segment decreased over time suggesting that regenerating axons are not entirely responsible for the down-regulation. These findings have clinical implications on when it is worthwhile to reconstruct nerve injuries. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
reconstruction, nerve crush, nerve transection, ATF 3
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
volume
41
issue
4
pages
158 - 166
publisher
Taylor & Francis
external identifiers
  • wos:000248752300002
  • scopus:34548085207
ISSN
1651-2073
DOI
10.1080/02844310701318288
language
English
LU publication?
yes
id
8eeecc6a-1ba0-4ead-88a8-108c4dfdc3dc (old id 655587)
date added to LUP
2007-12-13 11:22:59
date last changed
2017-01-01 07:17:37
@article{8eeecc6a-1ba0-4ead-88a8-108c4dfdc3dc,
  abstract     = {Staining by activating transcription factor 3 (ATF3), a neuronal marker of nerve injury, was examined by immunocytochemistry in neurons and Schwann cells after crush or transection (regeneration inhibited) of rat sciatic nerve. ATF3 immunoreactivity peaked in neurons after three days and then gradually subsided to normal within 12 weeks after the crush. The response lasted somewhat longer and declined over time in spinal cord neurons but not in those of dorsal root ganglia (DRG) after transection, indicating a differential regulation of sensory and motor neurons. ATF3 expression was more pronounced in Schwann cells, and remained longer after transection, implying that to some extent regenerating axons produce signals that reduce ATF3 expression in Schwann cells. However, even after transection without repair (no contact with regenerating axons), ATF3 expression in Schwann cells in the distal segment decreased over time suggesting that regenerating axons are not entirely responsible for the down-regulation. These findings have clinical implications on when it is worthwhile to reconstruct nerve injuries.},
  author       = {Kataoka, Kazuya | and Kanje, Martin and Dahlin, Lars},
  issn         = {1651-2073},
  keyword      = {reconstruction,nerve crush,nerve transection,ATF 3},
  language     = {eng},
  number       = {4},
  pages        = {158--166},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery},
  title        = {Induction of activating transcription factor 3 after different sciatic nerve injuries in adult rats},
  url          = {http://dx.doi.org/10.1080/02844310701318288},
  volume       = {41},
  year         = {2007},
}