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Subclinical sympathetic neuropathy appears early in the course of Crohn's disease

Ohlsson, Bodil LU ; Sundkvist, Göran LU and Lindgren, Stefan LU (2007) In BMC Gastroenterology 7.
Abstract
Background: We have previously demonstrated that patients with Crohn's disease ( CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. Methods: Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes included heart rate reaction to tilt ( acceleration index - Al, brake index - BI) and heart rate variation to deep-breathing (expiration/ inspiration index-E/l). Seven years later the same examinations were repeated, and in addition we examined the vasoconstriction response to indirect cooling by laser Doppler ( vasoconstriction-index -... (More)
Background: We have previously demonstrated that patients with Crohn's disease ( CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. Methods: Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes included heart rate reaction to tilt ( acceleration index - Al, brake index - BI) and heart rate variation to deep-breathing (expiration/ inspiration index-E/l). Seven years later the same examinations were repeated, and in addition we examined the vasoconstriction response to indirect cooling by laser Doppler ( vasoconstriction-index - VAC-index). The results were compared with healthy individuals. Results: There was no difference in the blood pressure between controls and the patients with CD at rest, but eight minutes after tilt, the systolic blood pressure was lowered in patients compared to controls, both at the first assessment ( p = 0.016) and after seven years ( p = 0.042). The change in systolic blood pressure between rest and eight minutes after tilt was not significant at the first assessment, while a significant change compared to controls was observed seven years later ( p = 0.028). This indicates a progressive dysfunction. There were no differences in E/l, Al, Bl or VAC indexes between patients and controls. Conclusion: Patients with CD suffer from autonomic neuropathy early in their disease, suggesting involvement of many different organ systems in this entity. (Less)
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publication status
published
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BMC Gastroenterology
volume
7
publisher
BMC Biomedical Centre, Lund University
external identifiers
  • wos:000249902400001
  • scopus:35348814978
ISSN
1471-230X
DOI
10.1186/1471-230X-7-33
language
English
LU publication?
yes
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The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes Epidemiology and Neuropathy (013241560), Chronic Inflammatory and Degenerative Diseases Research Unit (013242530)
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fac74344-5287-4b04-9c12-e2cc4e937bee (old id 655795)
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2016-04-01 16:59:28
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2020-02-19 03:40:12
@article{fac74344-5287-4b04-9c12-e2cc4e937bee,
  abstract     = {Background: We have previously demonstrated that patients with Crohn's disease ( CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. Methods: Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes included heart rate reaction to tilt ( acceleration index - Al, brake index - BI) and heart rate variation to deep-breathing (expiration/ inspiration index-E/l). Seven years later the same examinations were repeated, and in addition we examined the vasoconstriction response to indirect cooling by laser Doppler ( vasoconstriction-index - VAC-index). The results were compared with healthy individuals. Results: There was no difference in the blood pressure between controls and the patients with CD at rest, but eight minutes after tilt, the systolic blood pressure was lowered in patients compared to controls, both at the first assessment ( p = 0.016) and after seven years ( p = 0.042). The change in systolic blood pressure between rest and eight minutes after tilt was not significant at the first assessment, while a significant change compared to controls was observed seven years later ( p = 0.028). This indicates a progressive dysfunction. There were no differences in E/l, Al, Bl or VAC indexes between patients and controls. Conclusion: Patients with CD suffer from autonomic neuropathy early in their disease, suggesting involvement of many different organ systems in this entity.},
  author       = {Ohlsson, Bodil and Sundkvist, Göran and Lindgren, Stefan},
  issn         = {1471-230X},
  language     = {eng},
  publisher    = {BMC Biomedical Centre, Lund University},
  series       = {BMC Gastroenterology},
  title        = {Subclinical sympathetic neuropathy appears early in the course of Crohn's disease},
  url          = {http://dx.doi.org/10.1186/1471-230X-7-33},
  doi          = {10.1186/1471-230X-7-33},
  volume       = {7},
  year         = {2007},
}