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Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations

Sjakste, T.; Kalis, M.; Poudziunas, I.; Pirags, V.; Lazdins, M.; Groop, Leif LU and Sjakste, N. (2007) In Annals of Human Genetics 71. p.772-776
Abstract
A polymorphic microsatellite in intron 6 of the human proteasome core particle PSMA6 gene (HSMS006), and four other microsatellites localized upstream on human chromosome 14q13.2 (HSMS801, HSMS702, HSMS701, HSMS602), were genotyped in 104 type 2 diabetic patients and 129 age-matched control subjects from Latvia and replicated in 91 type 2 diabetic patients and 88 age-matched healthy control subjects from the Botnia Study in Finland. In type 2 diabetic patients from both populations the HSMS006 (TG)22 allele was two times more frequent compared to the control group. In the Latvian population the (CAA)8 allele of the HSMS602 marker was less frequent in the diabetic group, as was the (AC)24 allele of microsatellite HSMS801. Allele frequencies... (More)
A polymorphic microsatellite in intron 6 of the human proteasome core particle PSMA6 gene (HSMS006), and four other microsatellites localized upstream on human chromosome 14q13.2 (HSMS801, HSMS702, HSMS701, HSMS602), were genotyped in 104 type 2 diabetic patients and 129 age-matched control subjects from Latvia and replicated in 91 type 2 diabetic patients and 88 age-matched healthy control subjects from the Botnia Study in Finland. In type 2 diabetic patients from both populations the HSMS006 (TG)22 allele was two times more frequent compared to the control group. In the Latvian population the (CAA)8 allele of the HSMS602 marker was less frequent in the diabetic group, as was the (AC)24 allele of microsatellite HSMS801. Allele frequencies of the HSMS701 and 702 repeats were similar in healthy controls and type 2 diabetic patients. In conclusion, our data suggest that variants in the PSMA6 gene on chromosome 14q13.2 are associated with type 2 diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
proteasomes, Chromosome 14, type 2 diabetes mellitus, microsatellites, PSMA6, polymorphism
in
Annals of Human Genetics
volume
71
pages
772 - 776
publisher
Wiley-Blackwell
external identifiers
  • wos:000249923200009
  • scopus:34948885086
ISSN
1469-1809
DOI
10.1111/j.1469-1809.2007.00372.x
language
English
LU publication?
yes
id
652c581e-23ae-4989-b0b3-d8ffe867de52 (old id 655805)
date added to LUP
2007-12-19 16:11:00
date last changed
2017-08-06 03:45:18
@article{652c581e-23ae-4989-b0b3-d8ffe867de52,
  abstract     = {A polymorphic microsatellite in intron 6 of the human proteasome core particle PSMA6 gene (HSMS006), and four other microsatellites localized upstream on human chromosome 14q13.2 (HSMS801, HSMS702, HSMS701, HSMS602), were genotyped in 104 type 2 diabetic patients and 129 age-matched control subjects from Latvia and replicated in 91 type 2 diabetic patients and 88 age-matched healthy control subjects from the Botnia Study in Finland. In type 2 diabetic patients from both populations the HSMS006 (TG)22 allele was two times more frequent compared to the control group. In the Latvian population the (CAA)8 allele of the HSMS602 marker was less frequent in the diabetic group, as was the (AC)24 allele of microsatellite HSMS801. Allele frequencies of the HSMS701 and 702 repeats were similar in healthy controls and type 2 diabetic patients. In conclusion, our data suggest that variants in the PSMA6 gene on chromosome 14q13.2 are associated with type 2 diabetes.},
  author       = {Sjakste, T. and Kalis, M. and Poudziunas, I. and Pirags, V. and Lazdins, M. and Groop, Leif and Sjakste, N.},
  issn         = {1469-1809},
  keyword      = {proteasomes,Chromosome 14,type 2 diabetes mellitus,microsatellites,PSMA6,polymorphism},
  language     = {eng},
  pages        = {772--776},
  publisher    = {Wiley-Blackwell},
  series       = {Annals of Human Genetics},
  title        = {Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations},
  url          = {http://dx.doi.org/10.1111/j.1469-1809.2007.00372.x},
  volume       = {71},
  year         = {2007},
}