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Blood pressure in middle-aged women: are androgens involved? A population-based study of Swedish women: the Women's Health in the Lund Area study

Khatibi Esfanjani, Ali LU ; Agardh, Carl-David LU ; Nyberg, Per LU ; Lidfeldt, Jonas LU and Samsioe, Göran LU (2007) In Journal of Hypertension 25(10). p.2044-2050
Abstract
Objective To assess the prevalence of hypertension and use of antihypertensive drug therapy in relation to menopausal status and to delineate perceived associations between androgens and blood pressure in perimenopausal women. Methods A population- based sample of women aged 50 - 59 ( nU6893). Women were divided into three groups according to their hormonal status: premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy. Result In the premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy groups, the prevalence of high blood pressure (>= - 140mmHg systolic or >= 90mmHg diastolic) was 43.9, 49.9 and 45.8%, respectively. In women with normal blood pressure,... (More)
Objective To assess the prevalence of hypertension and use of antihypertensive drug therapy in relation to menopausal status and to delineate perceived associations between androgens and blood pressure in perimenopausal women. Methods A population- based sample of women aged 50 - 59 ( nU6893). Women were divided into three groups according to their hormonal status: premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy. Result In the premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy groups, the prevalence of high blood pressure (>= - 140mmHg systolic or >= 90mmHg diastolic) was 43.9, 49.9 and 45.8%, respectively. In women with normal blood pressure, adjusting for age, body mass index and smoking, there were negative associations between serum testosterone and systolic blood pressure in the total sample ( P< 0.01) and the postmenopausal without hormone therapy group ( P< 0.05). In women using antihypertensive drug therapy with a blood pressure of at least 140/ 90mmHg, positive associations were found between serum testosterone and systolic blood pressure in the total series ( P< 0.05) and in the postmenopausal without hormone therapy group ( P< 0.05). Conclusion Abnormal blood pressure is common in middle- aged women regardless of hormonal status. Our findings suggest that testosterone could have a dual influence on blood pressure in perimenopausal women. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood pressure, menopause, androgen, testosterone
in
Journal of Hypertension
volume
25
issue
10
pages
2044 - 2050
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000249780000013
  • scopus:34748813116
ISSN
1473-5598
DOI
10.1097/HJH.0b013e32828626f9
language
English
LU publication?
yes
id
ce1b5124-cdad-4f87-89b0-718200f61f96 (old id 656020)
alternative location
http://www.jhypertension.com/pt/re/jhypertension/abstract.00004872-200710000-00013.htm
date added to LUP
2007-12-12 14:03:29
date last changed
2017-04-09 04:24:07
@article{ce1b5124-cdad-4f87-89b0-718200f61f96,
  abstract     = {Objective To assess the prevalence of hypertension and use of antihypertensive drug therapy in relation to menopausal status and to delineate perceived associations between androgens and blood pressure in perimenopausal women. Methods A population- based sample of women aged 50 - 59 ( nU6893). Women were divided into three groups according to their hormonal status: premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy. Result In the premenopausal, postmenopausal without hormone therapy, and postmenopausal with hormone therapy groups, the prevalence of high blood pressure (&gt;= - 140mmHg systolic or &gt;= 90mmHg diastolic) was 43.9, 49.9 and 45.8%, respectively. In women with normal blood pressure, adjusting for age, body mass index and smoking, there were negative associations between serum testosterone and systolic blood pressure in the total sample ( P&lt; 0.01) and the postmenopausal without hormone therapy group ( P&lt; 0.05). In women using antihypertensive drug therapy with a blood pressure of at least 140/ 90mmHg, positive associations were found between serum testosterone and systolic blood pressure in the total series ( P&lt; 0.05) and in the postmenopausal without hormone therapy group ( P&lt; 0.05). Conclusion Abnormal blood pressure is common in middle- aged women regardless of hormonal status. Our findings suggest that testosterone could have a dual influence on blood pressure in perimenopausal women.},
  author       = {Khatibi Esfanjani, Ali and Agardh, Carl-David and Nyberg, Per and Lidfeldt, Jonas and Samsioe, Göran},
  issn         = {1473-5598},
  keyword      = {blood pressure,menopause,androgen,testosterone},
  language     = {eng},
  number       = {10},
  pages        = {2044--2050},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Blood pressure in middle-aged women: are androgens involved? A population-based study of Swedish women: the Women's Health in the Lund Area study},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e32828626f9},
  volume       = {25},
  year         = {2007},
}