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Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: maternal characteristics

Wikner, Birgitta Norstedt; Stiller, Carl-Olav; Källén, Bengt LU and Asker, Charlotte (2007) In Pharmacoepidemiology and Drug Safety 16(9). p.988-994
Abstract
Background Use of benzodiazepine (BZD) drugs or hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy may represent a hazard for the foetus. In order to analyse this in an adequate way, knowledge of maternal characteristics as putative confounders is needed. Methods In the Swedish Medical Birth Register, 2149 pregnant women using BZDs or HBRAs were identified, 1944 of them in early pregnancy. These women were compared with other women (n = 859 455) giving births during the same period (1 July 1995-31 December 2004). The following maternal characteristics were studied: age, parity, smoking habits, education, previous miscarriages, years of involuntary childlessness as an estimate of subfertility, concomitant drug use and some... (More)
Background Use of benzodiazepine (BZD) drugs or hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy may represent a hazard for the foetus. In order to analyse this in an adequate way, knowledge of maternal characteristics as putative confounders is needed. Methods In the Swedish Medical Birth Register, 2149 pregnant women using BZDs or HBRAs were identified, 1944 of them in early pregnancy. These women were compared with other women (n = 859 455) giving births during the same period (1 July 1995-31 December 2004). The following maternal characteristics were studied: age, parity, smoking habits, education, previous miscarriages, years of involuntary childlessness as an estimate of subfertility, concomitant drug use and some pregnancy complications. Results Use and/or reporting of BZDs or HBRAs increased with maternal age. It was higher at first and 4+ parity and increased markedly with maternal smoking. Women with low education reported a higher use than women with high education. Previous miscarriage or subfertility had little impact on the use of these drugs. Preterm birth and caesarean section (also at term birth) were more common than expected. In women using BZDs or HBRAs, other types of psychoactive drugs were used in excess. Conclusions Women using BZDs or HBRAs differ in many aspects from women not using those drugs. These differences may act as confounders in the analysis of pregnancy outcome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
maternal, benzodiazepines, benzodiazepine receptor agonists, characteristics, pregnancy
in
Pharmacoepidemiology and Drug Safety
volume
16
issue
9
pages
988 - 994
publisher
John Wiley & Sons
external identifiers
  • wos:000249477500006
  • scopus:34548719380
ISSN
1053-8569
DOI
10.1002/pds.1391
language
English
LU publication?
yes
id
4dbdcd5e-c6a6-4324-abb6-76c2499606e9 (old id 656435)
date added to LUP
2007-12-19 08:55:29
date last changed
2017-07-02 03:30:10
@article{4dbdcd5e-c6a6-4324-abb6-76c2499606e9,
  abstract     = {Background Use of benzodiazepine (BZD) drugs or hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy may represent a hazard for the foetus. In order to analyse this in an adequate way, knowledge of maternal characteristics as putative confounders is needed. Methods In the Swedish Medical Birth Register, 2149 pregnant women using BZDs or HBRAs were identified, 1944 of them in early pregnancy. These women were compared with other women (n = 859 455) giving births during the same period (1 July 1995-31 December 2004). The following maternal characteristics were studied: age, parity, smoking habits, education, previous miscarriages, years of involuntary childlessness as an estimate of subfertility, concomitant drug use and some pregnancy complications. Results Use and/or reporting of BZDs or HBRAs increased with maternal age. It was higher at first and 4+ parity and increased markedly with maternal smoking. Women with low education reported a higher use than women with high education. Previous miscarriage or subfertility had little impact on the use of these drugs. Preterm birth and caesarean section (also at term birth) were more common than expected. In women using BZDs or HBRAs, other types of psychoactive drugs were used in excess. Conclusions Women using BZDs or HBRAs differ in many aspects from women not using those drugs. These differences may act as confounders in the analysis of pregnancy outcome.},
  author       = {Wikner, Birgitta Norstedt and Stiller, Carl-Olav and Källén, Bengt and Asker, Charlotte},
  issn         = {1053-8569},
  keyword      = {maternal,benzodiazepines,benzodiazepine receptor agonists,characteristics,pregnancy},
  language     = {eng},
  number       = {9},
  pages        = {988--994},
  publisher    = {John Wiley & Sons},
  series       = {Pharmacoepidemiology and Drug Safety},
  title        = {Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: maternal characteristics},
  url          = {http://dx.doi.org/10.1002/pds.1391},
  volume       = {16},
  year         = {2007},
}