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The role of leukotriene receptor signaling in inflammation and cancer

Massoumi, Ramin LU and Sjölander, Anita LU (2007) In Scientific World Journal 7. p.1413-1421
Abstract
Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT(1) receptor signaling pathway. In addition, we delineate... (More)
Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT(1) receptor signaling pathway. In addition, we delineate how continuous CysLT(1) receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CysLT(1) receptor, proliferation, leukotrienes, survival
in
Scientific World Journal
volume
7
pages
1413 - 1421
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000249432900010
  • scopus:34548809284
ISSN
2356-6140
DOI
10.1100/tsw.2007.200
language
English
LU publication?
yes
id
d9cbef75-18e3-4b9c-a996-3331bd78478e (old id 656868)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17767358&dopt=Abstract
date added to LUP
2007-12-15 13:59:50
date last changed
2017-07-09 04:24:01
@article{d9cbef75-18e3-4b9c-a996-3331bd78478e,
  abstract     = {Leukotrienes (LTs) and prostaglandins (PGs) are metabolites of arachidonic acid that play major roles in various inflammatory conditions. The release of these mediators, by cells recruited to or present at the site of inflammation, modulate/influence the magnitude of the inflammatory response. A better understanding of eicosanoids and how their receptors trigger intracellular signaling during inflammatory conditions is helping to elucidate the well-known connection between chronic inflammatory disease and neoplastic transformation. In the current review, we summarize the role of LTs and PGs in chronic inflammation and, in particular, we focus on recent insights into the role of CysLT(1) receptor signaling pathway. In addition, we delineate how continuous CysLT(1) receptor activation and signaling can increase cell survival and proliferation as important early steps toward oncogenicity.},
  author       = {Massoumi, Ramin and Sjölander, Anita},
  issn         = {2356-6140},
  keyword      = {CysLT(1) receptor,proliferation,leukotrienes,survival},
  language     = {eng},
  pages        = {1413--1421},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Scientific World Journal},
  title        = {The role of leukotriene receptor signaling in inflammation and cancer},
  url          = {http://dx.doi.org/10.1100/tsw.2007.200},
  volume       = {7},
  year         = {2007},
}