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Long-term follow-up of the hepatitis CHENCORE cohort: response to therapy and occurrence of liver-related complications

Pradat, P.; Tillmann, H. L.; Sauleda, S.; Braconier, Jean Henrik LU ; Saracco, G.; Thursz, M.; Goldin, R.; Winkler, R.; Alberti, A. and Esteban, J.-I., et al. (2007) In Journal of Viral Hepatitis 14(8). p.556-563
Abstract
The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver... (More)
The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver complications during follow up, and 31% of non-responders did. Advanced age at infection and presence of the human leucocyte antigen (HLA) DRBI*1201-3 allele were possibly associated with a higher rate of progression to decompen- sated cirrhosis or HCC. Decompensated cirrhosis might be further associated with male gender, non-response to previous therapy, and lack of FILA DRBI*1301 allele, whereas HCC seems to be associated with the presence of the HLA DQ02 allele. Long-term follow up of HCV patients indicates that virological response persists over time and is associated with a very low incidence of liver complications. Advanced age at inclusion. advanced age at infection, viral genotype 1, non-response to previous therapy and possibly some specific HLA alleles are factors independently associated with a faster rate of progression towards liver complications. The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients. (Less)
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published
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keywords
human leucocyte antigen, carcinoma, hepatocellular, hepatitis C, follow up, cirrhosis, complications, viral clearance
in
Journal of Viral Hepatitis
volume
14
issue
8
pages
556 - 563
publisher
Wiley-Blackwell
external identifiers
  • wos:000248483100004
  • scopus:34447545514
ISSN
1365-2893
DOI
10.1111/j.1365-2893.2006.00829.x
language
English
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yes
id
05158168-7cd0-4331-a4f4-902e26021026 (old id 657096)
date added to LUP
2007-12-20 07:49:15
date last changed
2017-04-30 09:08:06
@article{05158168-7cd0-4331-a4f4-902e26021026,
  abstract     = {The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver complications during follow up, and 31% of non-responders did. Advanced age at infection and presence of the human leucocyte antigen (HLA) DRBI*1201-3 allele were possibly associated with a higher rate of progression to decompen- sated cirrhosis or HCC. Decompensated cirrhosis might be further associated with male gender, non-response to previous therapy, and lack of FILA DRBI*1301 allele, whereas HCC seems to be associated with the presence of the HLA DQ02 allele. Long-term follow up of HCV patients indicates that virological response persists over time and is associated with a very low incidence of liver complications. Advanced age at inclusion. advanced age at infection, viral genotype 1, non-response to previous therapy and possibly some specific HLA alleles are factors independently associated with a faster rate of progression towards liver complications. The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients.},
  author       = {Pradat, P. and Tillmann, H. L. and Sauleda, S. and Braconier, Jean Henrik and Saracco, G. and Thursz, M. and Goldin, R. and Winkler, R. and Alberti, A. and Esteban, J.-I. and Hadziyannis, S. and Rizzetto, M. and Thomas, H. and Manns, M. P. and Trepo, C.},
  issn         = {1365-2893},
  keyword      = {human leucocyte antigen,carcinoma,hepatocellular,hepatitis C,follow up,cirrhosis,complications,viral clearance},
  language     = {eng},
  number       = {8},
  pages        = {556--563},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Viral Hepatitis},
  title        = {Long-term follow-up of the hepatitis CHENCORE cohort: response to therapy and occurrence of liver-related complications},
  url          = {http://dx.doi.org/10.1111/j.1365-2893.2006.00829.x},
  volume       = {14},
  year         = {2007},
}