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Plum-pudding gels as a platform for drug delivery: Understanding the effects of the different components on the diffusion behavior of solutes

Salvati, Anna LU ; Söderman, Olle LU and Lynch, Iseult LU (2007) In The Journal of Physical Chemistry Part B 111(25). p.7367-7376
Abstract
The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The effect of the different components has been examined, for example, the size of the probe, the bulk structure, and the microgel nature. Particles were characterized prior to their insertion into the hydrogel in order to describe their properties as a function of size and cross-linker content, thus revealing different swelling behaviors. The biggest... (More)
The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The effect of the different components has been examined, for example, the size of the probe, the bulk structure, and the microgel nature. Particles were characterized prior to their insertion into the hydrogel in order to describe their properties as a function of size and cross-linker content, thus revealing different swelling behaviors. The biggest effects on the diffusion of the PEG probes were related to the bulk structure, and no major effects were registered by the addition of different microgels into the hydrogel network. We attempt to rationalize this behavior in terms of the composite gel structure and discuss the results in terms of their meaning for controlled drug delivery strategies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
111
issue
25
pages
7367 - 7376
publisher
The American Chemical Society
external identifiers
  • wos:000247435700054
  • scopus:34547292379
ISSN
1520-5207
DOI
10.1021/jp069051u
language
English
LU publication?
yes
id
dfae35eb-9fa5-4dc0-bbd6-b2054382567e (old id 657460)
date added to LUP
2007-12-18 13:20:45
date last changed
2017-08-27 05:23:24
@article{dfae35eb-9fa5-4dc0-bbd6-b2054382567e,
  abstract     = {The internal structure of composite gels made of responsive microgel particles inserted into a bulk hydrogel (N-isopropylacrylamide microgel particles in a cross-linked dimethylacrylamide matrix) has been investigated from the diffusion behavior of poly(ethylene glycol) (PEG) probes through the network, in the absence of specific interactions between the diffusing molecules and the system. The effect of the different components has been examined, for example, the size of the probe, the bulk structure, and the microgel nature. Particles were characterized prior to their insertion into the hydrogel in order to describe their properties as a function of size and cross-linker content, thus revealing different swelling behaviors. The biggest effects on the diffusion of the PEG probes were related to the bulk structure, and no major effects were registered by the addition of different microgels into the hydrogel network. We attempt to rationalize this behavior in terms of the composite gel structure and discuss the results in terms of their meaning for controlled drug delivery strategies.},
  author       = {Salvati, Anna and Söderman, Olle and Lynch, Iseult},
  issn         = {1520-5207},
  language     = {eng},
  number       = {25},
  pages        = {7367--7376},
  publisher    = {The American Chemical Society},
  series       = {The Journal of Physical Chemistry Part B},
  title        = {Plum-pudding gels as a platform for drug delivery: Understanding the effects of the different components on the diffusion behavior of solutes},
  url          = {http://dx.doi.org/10.1021/jp069051u},
  volume       = {111},
  year         = {2007},
}