The occurrence of neuropeptides at different stages of DBM-induced heterotopic bone formation
(1990) In Bone and mineral 10(2). p.95-107- Abstract
In developing heterotopic bone in the rat, induced by allogeneic bone matrix, we immunohistochemically detected nerves containing substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase (TH). After 10 days they were dicernible amidst differentiating chondroblastoid cells in fibrous tissue around and within the implants. Over the next 3 weeks, the nerves increased in number and gradually attained a shape and distribution resembling normal osseal nerves; varicose fibres frequently occurred in periosteum-like fibrous tissue and bone marrow adjacent to newly formed bone. At 8 weeks, NPY-fibres increased, particularly in the marrow and this abundance of... (More)
In developing heterotopic bone in the rat, induced by allogeneic bone matrix, we immunohistochemically detected nerves containing substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase (TH). After 10 days they were dicernible amidst differentiating chondroblastoid cells in fibrous tissue around and within the implants. Over the next 3 weeks, the nerves increased in number and gradually attained a shape and distribution resembling normal osseal nerves; varicose fibres frequently occurred in periosteum-like fibrous tissue and bone marrow adjacent to newly formed bone. At 8 weeks, NPY-fibres increased, particularly in the marrow and this abundance of NPY fibres remained at 16 weeks. VIP-immunoreactive fibres were only observed in the surrounding periosteum-like fibrous tissue 4-6 weeks after implantation. These observations, in combination with recent findings of receptors to neuropeptides on bone cells, suggest a neurogenic influence on physiological processes in bone tissue.
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- author
- Bjurholm, A ; Kreicbergs, A ; Dahlberg, L LU and Schultzberg, M
- organization
- publishing date
- 1990-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Bone Development/physiology, Bone Matrix/transplantation, Bone and Bones/innervation, Calcification, Physiologic, Calcitonin Gene-Related Peptide/metabolism, Fluorescent Antibody Technique, Male, Neuropeptide Y/metabolism, Neuropeptides/metabolism, Rats, Rats, Inbred Strains, Substance P/metabolism, Transplantation, Heterotopic, Tyrosine 3-Monooxygenase/metabolism, Vasoactive Intestinal Peptide/metabolism
- in
- Bone and mineral
- volume
- 10
- issue
- 2
- pages
- 95 - 107
- publisher
- Elsevier
- external identifiers
-
- scopus:0025148018
- pmid:1698491
- ISSN
- 0169-6009
- DOI
- 10.1016/0169-6009(90)90085-t
- language
- English
- LU publication?
- yes
- id
- 6574a175-c695-4a5b-b319-19c506fc152c
- date added to LUP
- 2024-04-09 09:00:08
- date last changed
- 2024-04-10 04:01:26
@article{6574a175-c695-4a5b-b319-19c506fc152c,
abstract = {{<p>In developing heterotopic bone in the rat, induced by allogeneic bone matrix, we immunohistochemically detected nerves containing substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase (TH). After 10 days they were dicernible amidst differentiating chondroblastoid cells in fibrous tissue around and within the implants. Over the next 3 weeks, the nerves increased in number and gradually attained a shape and distribution resembling normal osseal nerves; varicose fibres frequently occurred in periosteum-like fibrous tissue and bone marrow adjacent to newly formed bone. At 8 weeks, NPY-fibres increased, particularly in the marrow and this abundance of NPY fibres remained at 16 weeks. VIP-immunoreactive fibres were only observed in the surrounding periosteum-like fibrous tissue 4-6 weeks after implantation. These observations, in combination with recent findings of receptors to neuropeptides on bone cells, suggest a neurogenic influence on physiological processes in bone tissue.</p>}},
author = {{Bjurholm, A and Kreicbergs, A and Dahlberg, L and Schultzberg, M}},
issn = {{0169-6009}},
keywords = {{Animals; Bone Development/physiology; Bone Matrix/transplantation; Bone and Bones/innervation; Calcification, Physiologic; Calcitonin Gene-Related Peptide/metabolism; Fluorescent Antibody Technique; Male; Neuropeptide Y/metabolism; Neuropeptides/metabolism; Rats; Rats, Inbred Strains; Substance P/metabolism; Transplantation, Heterotopic; Tyrosine 3-Monooxygenase/metabolism; Vasoactive Intestinal Peptide/metabolism}},
language = {{eng}},
number = {{2}},
pages = {{95--107}},
publisher = {{Elsevier}},
series = {{Bone and mineral}},
title = {{The occurrence of neuropeptides at different stages of DBM-induced heterotopic bone formation}},
url = {{http://dx.doi.org/10.1016/0169-6009(90)90085-t}},
doi = {{10.1016/0169-6009(90)90085-t}},
volume = {{10}},
year = {{1990}},
}