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Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases

Ahuja-Jensen, Poonam LU ; Johnsen-Soriano, Siv; Ahuja, Satpal LU ; Bosch-Morell, Francisco; Sancho-Tello, Maria; Romero, Francisco Javier; Abrahamson, Magnus LU and van Veen, Theo LU (2007) In NeuroReport 18(8). p.797-801
Abstract
Malondialdehyde, reduced glutathione, glutathione peroxidase, glutathione reductase and cysteine protease cathepsins at postnatal (PN) days 2, 7, 14, 21 and 28 in controls (wt) and the retinal degeneration 1 (rd1) mouse model for retinitis pigmentosa retinas were measured to determine oxidative stress. In PN28 wt and PN2 rd1 retinas, elevated malondialdehyde and low glutathione peroxidase activity indicate higher oxidative load, despite higher reduced glutathione in PN2 rd1 retinas. This is due to physiological exposure to light and retinal vascular/neural restructuring, respectively. Compared with wt retinas, relatively high malondialdehyde at PN2 and cathepsin levels at PN14, 21 and 28 in rd1 retinas indicate that cells of the residual... (More)
Malondialdehyde, reduced glutathione, glutathione peroxidase, glutathione reductase and cysteine protease cathepsins at postnatal (PN) days 2, 7, 14, 21 and 28 in controls (wt) and the retinal degeneration 1 (rd1) mouse model for retinitis pigmentosa retinas were measured to determine oxidative stress. In PN28 wt and PN2 rd1 retinas, elevated malondialdehyde and low glutathione peroxidase activity indicate higher oxidative load, despite higher reduced glutathione in PN2 rd1 retinas. This is due to physiological exposure to light and retinal vascular/neural restructuring, respectively. Compared with wt retinas, relatively high malondialdehyde at PN2 and cathepsin levels at PN14, 21 and 28 in rd1 retinas indicate that cells of the residual inner retina also contribute to the oxidative stress and retinal degeneration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
retinal degeneration, stress, oxidative, malondialdehyde, cysteine protease, glutathione system, rd1 mice
in
NeuroReport
volume
18
issue
8
pages
797 - 801
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000246568400015
  • scopus:34247616816
ISSN
1473-558X
language
English
LU publication?
yes
id
9a48df14-8004-4472-b277-3b6d45626915 (old id 659337)
alternative location
http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200705280-00015.htm
date added to LUP
2007-12-11 13:23:32
date last changed
2017-10-22 03:39:49
@article{9a48df14-8004-4472-b277-3b6d45626915,
  abstract     = {Malondialdehyde, reduced glutathione, glutathione peroxidase, glutathione reductase and cysteine protease cathepsins at postnatal (PN) days 2, 7, 14, 21 and 28 in controls (wt) and the retinal degeneration 1 (rd1) mouse model for retinitis pigmentosa retinas were measured to determine oxidative stress. In PN28 wt and PN2 rd1 retinas, elevated malondialdehyde and low glutathione peroxidase activity indicate higher oxidative load, despite higher reduced glutathione in PN2 rd1 retinas. This is due to physiological exposure to light and retinal vascular/neural restructuring, respectively. Compared with wt retinas, relatively high malondialdehyde at PN2 and cathepsin levels at PN14, 21 and 28 in rd1 retinas indicate that cells of the residual inner retina also contribute to the oxidative stress and retinal degeneration.},
  author       = {Ahuja-Jensen, Poonam and Johnsen-Soriano, Siv and Ahuja, Satpal and Bosch-Morell, Francisco and Sancho-Tello, Maria and Romero, Francisco Javier and Abrahamson, Magnus and van Veen, Theo},
  issn         = {1473-558X},
  keyword      = {retinal degeneration,stress,oxidative,malondialdehyde,cysteine protease,glutathione system,rd1 mice},
  language     = {eng},
  number       = {8},
  pages        = {797--801},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases},
  volume       = {18},
  year         = {2007},
}