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Hematopoietic stem cell aging: Mechanism and consequence

Rossi, Derrick J.; Bryder, David LU and Weissman, Irving L. (2007) In Experimental Gerontology 42(5). p.385-390
Abstract
Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lineage, myeloid, lymphoid, side population, stem cell, aging, potential, leukemia
in
Experimental Gerontology
volume
42
issue
5
pages
385 - 390
publisher
Elsevier
external identifiers
  • wos:000246532900002
  • scopus:34147109207
ISSN
1873-6815
DOI
10.1016/j.exger.2006.11.019
language
English
LU publication?
yes
id
9c3c985e-49a9-4037-ba15-0f8241094d7f (old id 659623)
date added to LUP
2007-12-14 12:52:00
date last changed
2017-10-01 03:47:33
@article{9c3c985e-49a9-4037-ba15-0f8241094d7f,
  abstract     = {Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.},
  author       = {Rossi, Derrick J. and Bryder, David and Weissman, Irving L.},
  issn         = {1873-6815},
  keyword      = {lineage,myeloid,lymphoid,side population,stem cell,aging,potential,leukemia},
  language     = {eng},
  number       = {5},
  pages        = {385--390},
  publisher    = {Elsevier},
  series       = {Experimental Gerontology},
  title        = {Hematopoietic stem cell aging: Mechanism and consequence},
  url          = {http://dx.doi.org/10.1016/j.exger.2006.11.019},
  volume       = {42},
  year         = {2007},
}