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Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can)

Lindkvist, Bjorn; Almquist, Martin LU ; Bjorge, Tone; Stocks, Tanja; Borena, Wegene; Johansen, Dorthe LU ; Hallmans, Goran; Engeland, Anders; Nagel, Gabriele and Jonsson, Hakan, et al. (2013) In Cancer Causes and Control 24(1). p.107-116
Abstract
Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma. The Metabolic Syndrome and Cancer Project (Me-Can) is a pooling of prospective cohorts in Austria, Norway, and Sweden with information on blood pressure, lipids, glucose, and BMI available in 578,700 individuals. Cox proportional hazards analysis was used to calculate hazard ratio (HR) of gastric adenocarcinoma using metabolic risk factors categorized into quintiles and transformed into z-scores (with mean = 0 and SD = 1). The standardized sum of all z-scores created a... (More)
Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma. The Metabolic Syndrome and Cancer Project (Me-Can) is a pooling of prospective cohorts in Austria, Norway, and Sweden with information on blood pressure, lipids, glucose, and BMI available in 578,700 individuals. Cox proportional hazards analysis was used to calculate hazard ratio (HR) of gastric adenocarcinoma using metabolic risk factors categorized into quintiles and transformed into z-scores (with mean = 0 and SD = 1). The standardized sum of all z-scores created a composite MetS score. In total, 1,210 incident cases of gastric adenocarcinoma were identified. Glucose was significantly associated with the risk of gastric adenocarcinoma [calibrated HR 1.58 (1.14-2.20) per one unit increment in z-score] in women. There was a statistically significant association between triglycerides and risk of gastric adenocarcinoma per mmol increment in triglycerides [HR 1.20 (1.06-1.36) per mmol] but not for the adjusted z-score in women. There were no significant association between any metabolic factors and gastric cancer among men. The composite MetS score was associated with the risk of gastric adenocarcinoma in women [HR 1.18 (1.00-1.38) per one unit increment in z-score] but not in men. Glucose and high levels of the composite MetS score were associated with an increased risk of gastric adenocarcinoma in women but not in men. (Less)
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Contribution to journal
publication status
published
subject
keywords
Gastric adenocarcinoma, Epidemiology, Cohort study, Metabolic syndrome, CONOR
in
Cancer Causes and Control
volume
24
issue
1
pages
107 - 116
publisher
Springer
external identifiers
  • wos:000312778000012
  • scopus:84871776513
ISSN
1573-7225
DOI
10.1007/s10552-012-0096-6
language
English
LU publication?
yes
id
659863ac-c1b3-45b4-9a0d-f41db4a3c872 (old id 3481027)
date added to LUP
2013-03-01 07:48:19
date last changed
2019-02-20 01:11:29
@article{659863ac-c1b3-45b4-9a0d-f41db4a3c872,
  abstract     = {Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma. The Metabolic Syndrome and Cancer Project (Me-Can) is a pooling of prospective cohorts in Austria, Norway, and Sweden with information on blood pressure, lipids, glucose, and BMI available in 578,700 individuals. Cox proportional hazards analysis was used to calculate hazard ratio (HR) of gastric adenocarcinoma using metabolic risk factors categorized into quintiles and transformed into z-scores (with mean = 0 and SD = 1). The standardized sum of all z-scores created a composite MetS score. In total, 1,210 incident cases of gastric adenocarcinoma were identified. Glucose was significantly associated with the risk of gastric adenocarcinoma [calibrated HR 1.58 (1.14-2.20) per one unit increment in z-score] in women. There was a statistically significant association between triglycerides and risk of gastric adenocarcinoma per mmol increment in triglycerides [HR 1.20 (1.06-1.36) per mmol] but not for the adjusted z-score in women. There were no significant association between any metabolic factors and gastric cancer among men. The composite MetS score was associated with the risk of gastric adenocarcinoma in women [HR 1.18 (1.00-1.38) per one unit increment in z-score] but not in men. Glucose and high levels of the composite MetS score were associated with an increased risk of gastric adenocarcinoma in women but not in men.},
  author       = {Lindkvist, Bjorn and Almquist, Martin and Bjorge, Tone and Stocks, Tanja and Borena, Wegene and Johansen, Dorthe and Hallmans, Goran and Engeland, Anders and Nagel, Gabriele and Jonsson, Hakan and Selmer, Randi and Diem, Guenter and Haggstrom, Christel and Tretli, Steinar and Stattin, Par and Manjer, Jonas},
  issn         = {1573-7225},
  keyword      = {Gastric adenocarcinoma,Epidemiology,Cohort study,Metabolic syndrome,CONOR},
  language     = {eng},
  number       = {1},
  pages        = {107--116},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can)},
  url          = {http://dx.doi.org/10.1007/s10552-012-0096-6},
  volume       = {24},
  year         = {2013},
}