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Serotypes with low invasive potential are associated with an impaired antibody response in invasive pneumococcal disease

Littorin, Nils LU ; Uddén, Fabian LU ; Ahl, Jonas LU ; Resman, Fredrik LU ; Slotved, Hans Christian; Athlin, Simon and Riesbeck, Kristian LU (2018) In Frontiers in Microbiology 9(NOV).
Abstract

Pneumococcal polysaccharide vaccines may elicit a hyporesponse under certain conditions. There is limited knowledge, however, on the type of specific antibody response in individuals with invasive pneumococcal disease (IPD). The aim of this study was to investigate the functional antibody response in patients with IPD caused by different serotypes. Pre-immune and convalescent sera from 40 patients (age 14-91 years) with IPD caused by serotypes with low (serotype 3, 19F, and 23F) and high (1, 4, 7F, and 14) invasive potential were investigated. For each patient, the homologous serotype-specific antibody concentration was determined. The functionality of induced antibodies post-IPD was evaluated in an opsonophagocytic assay (OPA).... (More)

Pneumococcal polysaccharide vaccines may elicit a hyporesponse under certain conditions. There is limited knowledge, however, on the type of specific antibody response in individuals with invasive pneumococcal disease (IPD). The aim of this study was to investigate the functional antibody response in patients with IPD caused by different serotypes. Pre-immune and convalescent sera from 40 patients (age 14-91 years) with IPD caused by serotypes with low (serotype 3, 19F, and 23F) and high (1, 4, 7F, and 14) invasive potential were investigated. For each patient, the homologous serotype-specific antibody concentration was determined. The functionality of induced antibodies post-IPD was evaluated in an opsonophagocytic assay (OPA). Undetectable or decreased pneumococcal killing in OPA following IPD, i.e., a nonfunctional antibody response, was observed in 24 of 40 patients (60%). Patients with nonfunctional antibody responses had lower serotype specific IgG antibody ratios post-IPD than patients with increased OPA titres. A nonfunctional antibody response was associated with low invasive serotypes (3, 19F, and 23F, p = 0.015). In conclusion, a nonfunctional antibody response may follow IPD, and was in our cohort associated to serotypes with low invasive potential. These findings need to be confirmed in a larger material.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibody, Opsonization, Sepsis, Serotype, Streptococcus pneumoniae
in
Frontiers in Microbiology
volume
9
issue
NOV
publisher
Frontiers
external identifiers
  • scopus:85056728506
ISSN
1664-302X
DOI
10.3389/fmicb.2018.02746
language
English
LU publication?
yes
id
65e81627-22f3-41ed-b6b8-8c772b331d93
date added to LUP
2018-11-27 12:53:18
date last changed
2019-06-08 02:19:45
@article{65e81627-22f3-41ed-b6b8-8c772b331d93,
  abstract     = {<p>Pneumococcal polysaccharide vaccines may elicit a hyporesponse under certain conditions. There is limited knowledge, however, on the type of specific antibody response in individuals with invasive pneumococcal disease (IPD). The aim of this study was to investigate the functional antibody response in patients with IPD caused by different serotypes. Pre-immune and convalescent sera from 40 patients (age 14-91 years) with IPD caused by serotypes with low (serotype 3, 19F, and 23F) and high (1, 4, 7F, and 14) invasive potential were investigated. For each patient, the homologous serotype-specific antibody concentration was determined. The functionality of induced antibodies post-IPD was evaluated in an opsonophagocytic assay (OPA). Undetectable or decreased pneumococcal killing in OPA following IPD, i.e., a nonfunctional antibody response, was observed in 24 of 40 patients (60%). Patients with nonfunctional antibody responses had lower serotype specific IgG antibody ratios post-IPD than patients with increased OPA titres. A nonfunctional antibody response was associated with low invasive serotypes (3, 19F, and 23F, p = 0.015). In conclusion, a nonfunctional antibody response may follow IPD, and was in our cohort associated to serotypes with low invasive potential. These findings need to be confirmed in a larger material.</p>},
  articleno    = {2746},
  author       = {Littorin, Nils and Uddén, Fabian and Ahl, Jonas and Resman, Fredrik and Slotved, Hans Christian and Athlin, Simon and Riesbeck, Kristian},
  issn         = {1664-302X},
  keyword      = {Antibody,Opsonization,Sepsis,Serotype,Streptococcus pneumoniae},
  language     = {eng},
  month        = {11},
  number       = {NOV},
  publisher    = {Frontiers},
  series       = {Frontiers in Microbiology},
  title        = {Serotypes with low invasive potential are associated with an impaired antibody response in invasive pneumococcal disease},
  url          = {http://dx.doi.org/10.3389/fmicb.2018.02746},
  volume       = {9},
  year         = {2018},
}