Sensorimotor performance and rotation correlate to lesion size in right but not left hemisphere brain infarcts in the spontaneously hypertensive rat
(1991) In Brain Research 547(2). p.249-257- Abstract
- In order to correlate behavioural deficits to lesion size and to reveal possible functional asymmetries in the rat brain, locomotor activity, rotation and sensorimotor integration to touch were studied in spontaneously hypertensive rats (SHR) subjected to right or left middle cerebral artery occlusion. Control and infarcted rats showed no difference in locomotor activity. Infarcted rats tended to rotate towards the side of the lesion. A large sensorimotor deficit was found contralateral to the infarcted hemisphere. The absolute values of the side-biases for the rotation and sensorimotor tests were of the same degree irrespective of lesion side. Whereas the left hemisphere lesion size did not correlate to the behavioural outcome, the size... (More)
- In order to correlate behavioural deficits to lesion size and to reveal possible functional asymmetries in the rat brain, locomotor activity, rotation and sensorimotor integration to touch were studied in spontaneously hypertensive rats (SHR) subjected to right or left middle cerebral artery occlusion. Control and infarcted rats showed no difference in locomotor activity. Infarcted rats tended to rotate towards the side of the lesion. A large sensorimotor deficit was found contralateral to the infarcted hemisphere. The absolute values of the side-biases for the rotation and sensorimotor tests were of the same degree irrespective of lesion side. Whereas the left hemisphere lesion size did not correlate to the behavioural outcome, the size of the right hemisphere lesion was highly correlated to the total sensorimotor deficit. Furthermore, the sensorimotor deficit of specific body parts was found to correlate to the damage of certain brain regions in a rostrocaudal fashion, reminiscent of a somatotopical organization. The extent of ipsilateral rotation correlated to brain tissue loss at the level of the posterior caudate-putamen. The present results indicate an asymmetrical organization for brain functions involved in the performance of the rotation and sensorimotor tests. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105920
- author
- Grabowski, Martin LU ; Nordborg, Claes and Johansson, Barbro LU
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Spontaneously hypertensive rat, Middle cerebral artery occlusion, Lesion size, Behavior, Brain lateralization
- in
- Brain Research
- volume
- 547
- issue
- 2
- pages
- 249 - 257
- publisher
- Elsevier
- external identifiers
-
- pmid:1884199
- scopus:0025854392
- ISSN
- 1872-6240
- DOI
- 10.1016/0006-8993(91)90968-2
- language
- English
- LU publication?
- yes
- id
- 65f00dd1-22b9-4d16-8f02-87a39e2de2cb (old id 1105920)
- date added to LUP
- 2016-04-01 12:19:55
- date last changed
- 2021-06-06 04:46:19
@article{65f00dd1-22b9-4d16-8f02-87a39e2de2cb,
abstract = {{In order to correlate behavioural deficits to lesion size and to reveal possible functional asymmetries in the rat brain, locomotor activity, rotation and sensorimotor integration to touch were studied in spontaneously hypertensive rats (SHR) subjected to right or left middle cerebral artery occlusion. Control and infarcted rats showed no difference in locomotor activity. Infarcted rats tended to rotate towards the side of the lesion. A large sensorimotor deficit was found contralateral to the infarcted hemisphere. The absolute values of the side-biases for the rotation and sensorimotor tests were of the same degree irrespective of lesion side. Whereas the left hemisphere lesion size did not correlate to the behavioural outcome, the size of the right hemisphere lesion was highly correlated to the total sensorimotor deficit. Furthermore, the sensorimotor deficit of specific body parts was found to correlate to the damage of certain brain regions in a rostrocaudal fashion, reminiscent of a somatotopical organization. The extent of ipsilateral rotation correlated to brain tissue loss at the level of the posterior caudate-putamen. The present results indicate an asymmetrical organization for brain functions involved in the performance of the rotation and sensorimotor tests.}},
author = {{Grabowski, Martin and Nordborg, Claes and Johansson, Barbro}},
issn = {{1872-6240}},
keywords = {{Spontaneously hypertensive rat; Middle cerebral artery occlusion; Lesion size; Behavior; Brain lateralization}},
language = {{eng}},
number = {{2}},
pages = {{249--257}},
publisher = {{Elsevier}},
series = {{Brain Research}},
title = {{Sensorimotor performance and rotation correlate to lesion size in right but not left hemisphere brain infarcts in the spontaneously hypertensive rat}},
url = {{http://dx.doi.org/10.1016/0006-8993(91)90968-2}},
doi = {{10.1016/0006-8993(91)90968-2}},
volume = {{547}},
year = {{1991}},
}