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Blood transfusion as a risk factor for non-Hodgkin lymphoma

Brandt, L LU ; Brandt, J LU ; Olsson, Håkan LU orcid ; Anderson, H LU and Möller, Torgil LU (1996) In British Journal of Cancer 73(9). p.1148-1151
Abstract

In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were... (More)

In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were known for 185 patients. For low-grade NHL of nodal B-cell chronic lymphocytic leukaemia (B-CLL) or immunocytoma type, the OR for transfusions was 4.15 (95% CI 1.92-9.01). For low-grade nodal lymphomas of follicle centre cell type and high-grade nodal lymphomas, no relation to transfusions could be demonstrated. For high-grade extranodal lymphoma as sole manifestation, OR for transfusions was 3.27 (95% CI 1.30-8.24). It is concluded that blood transfusion may be a risk factor for NHLs especially those of B-CLL or immunocytoma type and for high-grade extranodal lymphoma.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age Factors, Aged, Blood Transfusion, Case-Control Studies, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Male, Middle Aged, Registries, Sex Characteristics, Sex Factors, Sweden, Time Factors
in
British Journal of Cancer
volume
73
issue
9
pages
1148 - 1151
publisher
Nature Publishing Group
external identifiers
  • pmid:8624279
  • scopus:0030001617
ISSN
0007-0920
language
English
LU publication?
yes
id
65fa6008-c343-408d-8c52-c621243140a5
date added to LUP
2016-09-18 12:52:00
date last changed
2025-06-14 23:44:40
@article{65fa6008-c343-408d-8c52-c621243140a5,
  abstract     = {{<p>In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and &gt; or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were known for 185 patients. For low-grade NHL of nodal B-cell chronic lymphocytic leukaemia (B-CLL) or immunocytoma type, the OR for transfusions was 4.15 (95% CI 1.92-9.01). For low-grade nodal lymphomas of follicle centre cell type and high-grade nodal lymphomas, no relation to transfusions could be demonstrated. For high-grade extranodal lymphoma as sole manifestation, OR for transfusions was 3.27 (95% CI 1.30-8.24). It is concluded that blood transfusion may be a risk factor for NHLs especially those of B-CLL or immunocytoma type and for high-grade extranodal lymphoma.</p>}},
  author       = {{Brandt, L and Brandt, J and Olsson, Håkan and Anderson, H and Möller, Torgil}},
  issn         = {{0007-0920}},
  keywords     = {{Age Factors; Aged; Blood Transfusion; Case-Control Studies; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Registries; Sex Characteristics; Sex Factors; Sweden; Time Factors}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1148--1151}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{Blood transfusion as a risk factor for non-Hodgkin lymphoma}},
  volume       = {{73}},
  year         = {{1996}},
}