Blood transfusion as a risk factor for non-Hodgkin lymphoma
(1996) In British Journal of Cancer 73(9). p.1148-1151- Abstract
In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were... (More)
In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were known for 185 patients. For low-grade NHL of nodal B-cell chronic lymphocytic leukaemia (B-CLL) or immunocytoma type, the OR for transfusions was 4.15 (95% CI 1.92-9.01). For low-grade nodal lymphomas of follicle centre cell type and high-grade nodal lymphomas, no relation to transfusions could be demonstrated. For high-grade extranodal lymphoma as sole manifestation, OR for transfusions was 3.27 (95% CI 1.30-8.24). It is concluded that blood transfusion may be a risk factor for NHLs especially those of B-CLL or immunocytoma type and for high-grade extranodal lymphoma.
(Less)
- author
- Brandt, L LU ; Brandt, J LU ; Olsson, Håkan LU ; Anderson, H LU and Möller, Torgil LU
- organization
- publishing date
- 1996-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Age Factors, Aged, Blood Transfusion, Case-Control Studies, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Male, Middle Aged, Registries, Sex Characteristics, Sex Factors, Sweden, Time Factors
- in
- British Journal of Cancer
- volume
- 73
- issue
- 9
- pages
- 1148 - 1151
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:8624279
- scopus:0030001617
- ISSN
- 0007-0920
- language
- English
- LU publication?
- yes
- id
- 65fa6008-c343-408d-8c52-c621243140a5
- date added to LUP
- 2016-09-18 12:52:00
- date last changed
- 2024-03-07 12:13:17
@article{65fa6008-c343-408d-8c52-c621243140a5, abstract = {{<p>In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were known for 185 patients. For low-grade NHL of nodal B-cell chronic lymphocytic leukaemia (B-CLL) or immunocytoma type, the OR for transfusions was 4.15 (95% CI 1.92-9.01). For low-grade nodal lymphomas of follicle centre cell type and high-grade nodal lymphomas, no relation to transfusions could be demonstrated. For high-grade extranodal lymphoma as sole manifestation, OR for transfusions was 3.27 (95% CI 1.30-8.24). It is concluded that blood transfusion may be a risk factor for NHLs especially those of B-CLL or immunocytoma type and for high-grade extranodal lymphoma.</p>}}, author = {{Brandt, L and Brandt, J and Olsson, Håkan and Anderson, H and Möller, Torgil}}, issn = {{0007-0920}}, keywords = {{Age Factors; Aged; Blood Transfusion; Case-Control Studies; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Registries; Sex Characteristics; Sex Factors; Sweden; Time Factors}}, language = {{eng}}, number = {{9}}, pages = {{1148--1151}}, publisher = {{Nature Publishing Group}}, series = {{British Journal of Cancer}}, title = {{Blood transfusion as a risk factor for non-Hodgkin lymphoma}}, volume = {{73}}, year = {{1996}}, }