Blood transfusion as a risk factor for non-Hodgkin lymphoma
(1996) In British Journal of Cancer 73(9). p.1148-1151- Abstract
In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were... (More)
In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were known for 185 patients. For low-grade NHL of nodal B-cell chronic lymphocytic leukaemia (B-CLL) or immunocytoma type, the OR for transfusions was 4.15 (95% CI 1.92-9.01). For low-grade nodal lymphomas of follicle centre cell type and high-grade nodal lymphomas, no relation to transfusions could be demonstrated. For high-grade extranodal lymphoma as sole manifestation, OR for transfusions was 3.27 (95% CI 1.30-8.24). It is concluded that blood transfusion may be a risk factor for NHLs especially those of B-CLL or immunocytoma type and for high-grade extranodal lymphoma.
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- author
- Brandt, L LU ; Brandt, J LU ; Olsson, Håkan LU ; Anderson, H LU and Möller, Torgil LU
- organization
- publishing date
- 1996-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Age Factors, Aged, Blood Transfusion, Case-Control Studies, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Male, Middle Aged, Registries, Sex Characteristics, Sex Factors, Sweden, Time Factors
- in
- British Journal of Cancer
- volume
- 73
- issue
- 9
- pages
- 1148 - 1151
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:0030001617
- ISSN
- 0007-0920
- language
- English
- LU publication?
- yes
- id
- 65fa6008-c343-408d-8c52-c621243140a5
- date added to LUP
- 2016-09-18 12:52:00
- date last changed
- 2019-02-20 10:01:58
@article{65fa6008-c343-408d-8c52-c621243140a5, abstract = {<p>In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age- and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1-5, 6-15, 16-25 and > or = 26 years before diagnosis. In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60-4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated. Histological diagnoses (Kiel classification) and results of staging procedures were known for 185 patients. For low-grade NHL of nodal B-cell chronic lymphocytic leukaemia (B-CLL) or immunocytoma type, the OR for transfusions was 4.15 (95% CI 1.92-9.01). For low-grade nodal lymphomas of follicle centre cell type and high-grade nodal lymphomas, no relation to transfusions could be demonstrated. For high-grade extranodal lymphoma as sole manifestation, OR for transfusions was 3.27 (95% CI 1.30-8.24). It is concluded that blood transfusion may be a risk factor for NHLs especially those of B-CLL or immunocytoma type and for high-grade extranodal lymphoma.</p>}, author = {Brandt, L and Brandt, J and Olsson, Håkan and Anderson, H and Möller, Torgil}, issn = {0007-0920}, keyword = {Age Factors,Aged,Blood Transfusion,Case-Control Studies,Female,Humans,Leukemia, Lymphocytic, Chronic, B-Cell,Lymphoma, Non-Hodgkin,Male,Middle Aged,Registries,Sex Characteristics,Sex Factors,Sweden,Time Factors}, language = {eng}, number = {9}, pages = {1148--1151}, publisher = {Nature Publishing Group}, series = {British Journal of Cancer}, title = {Blood transfusion as a risk factor for non-Hodgkin lymphoma}, volume = {73}, year = {1996}, }