Advanced

The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite : A cohort study

Berntsson, Jonna LU ; Svensson, Maria C. LU ; Leandersson, Karin LU ; Nodin, Björn LU ; Micke, Patrick; Larsson, Anna H. LU ; Eberhard, Jakob LU and Jirström, Karin LU (2017) In International Journal of Cancer 141(8). p.1654-1666
Abstract

Accumulating evidence demonstrates an association between dense infiltration of lymphocytes and prognosis in colorectal cancer (CRC), but whether this prognostic impact differs by tumour location remains unknown. This study investigated the prognostic impact of cytotoxic and regulatory T cells in CRC, with particular reference to the anatomical subsite of the primary tumour. The density of CD3+, CD8+ and FoxP3+ tumour-infiltrating T cells was calculated in tissue microarrays with tumours from 557 incident CRC cases from a prospective population-based cohort. Kaplan–Meier and Cox regression analyses were applied to determine the impact of high and low lymphocyte density on 5-year overall survival, in... (More)

Accumulating evidence demonstrates an association between dense infiltration of lymphocytes and prognosis in colorectal cancer (CRC), but whether this prognostic impact differs by tumour location remains unknown. This study investigated the prognostic impact of cytotoxic and regulatory T cells in CRC, with particular reference to the anatomical subsite of the primary tumour. The density of CD3+, CD8+ and FoxP3+ tumour-infiltrating T cells was calculated in tissue microarrays with tumours from 557 incident CRC cases from a prospective population-based cohort. Kaplan–Meier and Cox regression analyses were applied to determine the impact of high and low lymphocyte density on 5-year overall survival, in subgroup analysis of right colon, left colon and rectum. High CD8+ cell density was a favourable prognostic factor for patients with right-sided colon tumours (hazard ratio [HR]=0.53, 95% confidence interval [CI] 0.29–0.95), independent of age, sex, TNM stage, differentiation grade and vascular invasion, with a significant prognostic interaction between CD8+ cells and right-sidedness (p = 0.031). High FoxP3+ cell density was an independent favourable prognostic factor only in patients with rectal tumours (HR = 0.54, 95% CI 0.30-0.99), and CD3+ cell density was an independent favourable prognostic factor for tumours in the right colon and rectum, but there was no significant prognostic interaction between CD3+ or FoxP3+ cells and sidedness. These results demonstrate that the prognostic impact of tumour-infiltrating lymphocytes in CRC differs by primary tumour site, further indicating that tumour location may be an important factor to take into consideration in therapeutic decisions, including eligibility for immunotherapy.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colorectal cancer, prognosis, sidedness, T cells, tumour location
in
International Journal of Cancer
volume
141
issue
8
pages
13 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85027884316
  • pmid:28677162
  • wos:000408107400015
ISSN
0020-7136
DOI
10.1002/ijc.30869
language
English
LU publication?
yes
id
6612288c-0675-4749-90d5-9ab07fa69b48
date added to LUP
2017-09-01 12:09:18
date last changed
2017-09-18 11:43:53
@article{6612288c-0675-4749-90d5-9ab07fa69b48,
  abstract     = {<p>Accumulating evidence demonstrates an association between dense infiltration of lymphocytes and prognosis in colorectal cancer (CRC), but whether this prognostic impact differs by tumour location remains unknown. This study investigated the prognostic impact of cytotoxic and regulatory T cells in CRC, with particular reference to the anatomical subsite of the primary tumour. The density of CD3<sup>+</sup>, CD8<sup>+</sup> and FoxP3<sup>+</sup> tumour-infiltrating T cells was calculated in tissue microarrays with tumours from 557 incident CRC cases from a prospective population-based cohort. Kaplan–Meier and Cox regression analyses were applied to determine the impact of high and low lymphocyte density on 5-year overall survival, in subgroup analysis of right colon, left colon and rectum. High CD8<sup>+</sup> cell density was a favourable prognostic factor for patients with right-sided colon tumours (hazard ratio [HR]=0.53, 95% confidence interval [CI] 0.29–0.95), independent of age, sex, TNM stage, differentiation grade and vascular invasion, with a significant prognostic interaction between CD8<sup>+</sup> cells and right-sidedness (p = 0.031). High FoxP3<sup>+</sup> cell density was an independent favourable prognostic factor only in patients with rectal tumours (HR = 0.54, 95% CI 0.30-0.99), and CD3<sup>+</sup> cell density was an independent favourable prognostic factor for tumours in the right colon and rectum, but there was no significant prognostic interaction between CD3<sup>+</sup> or FoxP3<sup>+</sup> cells and sidedness. These results demonstrate that the prognostic impact of tumour-infiltrating lymphocytes in CRC differs by primary tumour site, further indicating that tumour location may be an important factor to take into consideration in therapeutic decisions, including eligibility for immunotherapy.</p>},
  author       = {Berntsson, Jonna and Svensson, Maria C. and Leandersson, Karin and Nodin, Björn and Micke, Patrick and Larsson, Anna H. and Eberhard, Jakob and Jirström, Karin},
  issn         = {0020-7136},
  keyword      = {colorectal cancer,prognosis,sidedness,T cells,tumour location},
  language     = {eng},
  month        = {10},
  number       = {8},
  pages        = {1654--1666},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite : A cohort study},
  url          = {http://dx.doi.org/10.1002/ijc.30869},
  volume       = {141},
  year         = {2017},
}