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A long-term prospective study of optic neuritis: evaluation of risk factors

Sandberg Wollheim, Magnhild LU ; Bynke, Hans LU ; Cronqvist, Sten ; Holtås, Stig LU ; Platz, Per and Ryder, Lars P (1990) In Annals of Neurology 27(4). p.386-393
Abstract
Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was established in 33 patients. Actuarial analysis showed that the cumulative probability of developing MS within 15 years was 45%. Three risk factors were identified: low age and abnormal CSF at onset, and early recurrence of optic neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 antigen increased the risk for MS, but not... (More)
Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was established in 33 patients. Actuarial analysis showed that the cumulative probability of developing MS within 15 years was 45%. Three risk factors were identified: low age and abnormal CSF at onset, and early recurrence of optic neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 antigen increased the risk for MS, but not significantly. Magnetic resonance imaging detected bilateral discrete white matter lesions, similar to those in MS, in 11 of 25 patients, 7 to 18 years after the isolated attack of optic neuritis. Nine were among the 13 with abnormal CSF and only 2 belonged to the group of 12 with normal CSF (p = 0.01). Normal CSF at the onset of optic neuritis conferred better prognosis but did not preclude the development of MS. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Neurology
volume
27
issue
4
pages
386 - 393
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:2353793
  • scopus:0025271721
ISSN
1531-8249
DOI
10.1002/ana.410270406
language
English
LU publication?
yes
id
6618945a-67c4-47a3-aec2-867c505bf4a3 (old id 1105216)
date added to LUP
2016-04-01 11:48:21
date last changed
2021-09-19 04:27:04
@article{6618945a-67c4-47a3-aec2-867c505bf4a3,
  abstract     = {{Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was established in 33 patients. Actuarial analysis showed that the cumulative probability of developing MS within 15 years was 45%. Three risk factors were identified: low age and abnormal CSF at onset, and early recurrence of optic neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 antigen increased the risk for MS, but not significantly. Magnetic resonance imaging detected bilateral discrete white matter lesions, similar to those in MS, in 11 of 25 patients, 7 to 18 years after the isolated attack of optic neuritis. Nine were among the 13 with abnormal CSF and only 2 belonged to the group of 12 with normal CSF (p = 0.01). Normal CSF at the onset of optic neuritis conferred better prognosis but did not preclude the development of MS.}},
  author       = {{Sandberg Wollheim, Magnhild and Bynke, Hans and Cronqvist, Sten and Holtås, Stig and Platz, Per and Ryder, Lars P}},
  issn         = {{1531-8249}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{386--393}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Annals of Neurology}},
  title        = {{A long-term prospective study of optic neuritis: evaluation of risk factors}},
  url          = {{http://dx.doi.org/10.1002/ana.410270406}},
  doi          = {{10.1002/ana.410270406}},
  volume       = {{27}},
  year         = {{1990}},
}