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Optimization of energy-window settings for scatter correction in quantitative In-111 imaging: Comparison of measurements and Monte Carlo simulations

Holstensson, Maria ; Hindorf, Cecilia LU ; Ljungberg, Michael LU orcid ; Partridge, Mike and Flux, Glenn D. (2007) In Cancer Biotherapy & Radiopharmaceuticals 22(1). p.136-142
Abstract
Activity quantification in nuclear medicine imaging is highly desirable, particularly for dosimetry and biodistribution studies of radiopharmaceuticals. Quantitative In-111 imaging is increasingly important with the current interest in therapy using Y-90 radiolabeled antibodies. One of the major problems in quantification is scatter in the images, which leads to degradation of image quality. The aim of this study was to optimize the energy-window settings for quantitative In-111 imaging with a camera that enabled acquisition in three energy windows. Experimental measurements and Monte Carlo simulations, using the SI-MIND code, were conducted to investigate parameters such as sensitivity, image contrast, and image resolution. Estimated... (More)
Activity quantification in nuclear medicine imaging is highly desirable, particularly for dosimetry and biodistribution studies of radiopharmaceuticals. Quantitative In-111 imaging is increasingly important with the current interest in therapy using Y-90 radiolabeled antibodies. One of the major problems in quantification is scatter in the images, which leads to degradation of image quality. The aim of this study was to optimize the energy-window settings for quantitative In-111 imaging with a camera that enabled acquisition in three energy windows. Experimental measurements and Monte Carlo simulations, using the SI-MIND code, were conducted to investigate parameters such as sensitivity, image contrast, and image resolution. Estimated scatter-to-total ratios and distributions, as obtained by the different window settings, were compared with corresponding simulations. Results showed positive agreement between experimental measurements and results from simulations, both quantitatively and qualitatively. We conclude that of the investigated methods, the optimal energy-window setting was two windows centered at 171 and 245 keV, together with a broad scatter window located between the photopeaks. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
simulation, scatter, quantification, Monte Carlo, dosimetry, 111-In, imaging
in
Cancer Biotherapy & Radiopharmaceuticals
volume
22
issue
1
pages
136 - 142
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000246199200015
  • scopus:34247892381
ISSN
1557-8852
DOI
10.1089/cbr.2007.307
language
English
LU publication?
yes
id
813d7e45-2c15-403c-b717-a70c390185ad (old id 662756)
date added to LUP
2016-04-01 16:19:08
date last changed
2024-10-11 18:43:43
@article{813d7e45-2c15-403c-b717-a70c390185ad,
  abstract     = {{Activity quantification in nuclear medicine imaging is highly desirable, particularly for dosimetry and biodistribution studies of radiopharmaceuticals. Quantitative In-111 imaging is increasingly important with the current interest in therapy using Y-90 radiolabeled antibodies. One of the major problems in quantification is scatter in the images, which leads to degradation of image quality. The aim of this study was to optimize the energy-window settings for quantitative In-111 imaging with a camera that enabled acquisition in three energy windows. Experimental measurements and Monte Carlo simulations, using the SI-MIND code, were conducted to investigate parameters such as sensitivity, image contrast, and image resolution. Estimated scatter-to-total ratios and distributions, as obtained by the different window settings, were compared with corresponding simulations. Results showed positive agreement between experimental measurements and results from simulations, both quantitatively and qualitatively. We conclude that of the investigated methods, the optimal energy-window setting was two windows centered at 171 and 245 keV, together with a broad scatter window located between the photopeaks.}},
  author       = {{Holstensson, Maria and Hindorf, Cecilia and Ljungberg, Michael and Partridge, Mike and Flux, Glenn D.}},
  issn         = {{1557-8852}},
  keywords     = {{simulation; scatter; quantification; Monte Carlo; dosimetry; 111-In; imaging}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{136--142}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Cancer Biotherapy & Radiopharmaceuticals}},
  title        = {{Optimization of energy-window settings for scatter correction in quantitative In-111 imaging: Comparison of measurements and Monte Carlo simulations}},
  url          = {{http://dx.doi.org/10.1089/cbr.2007.307}},
  doi          = {{10.1089/cbr.2007.307}},
  volume       = {{22}},
  year         = {{2007}},
}