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Nordic biological specimen banks as basis for studies of cancer causes and control - more than 2 million sample donors, 25 million person years and 100 000 prospective cancers

Pukkala, Eero; Andersen, Aage; Berglund, Göran LU ; Gislefoss, Randi; Gudnason, Vilmundur; Hallmans, Goran; Jellum, Egil; Jousilahti, Pekka; Knekt, Paul and Koskela, Pentti, et al. (2007) In Acta Oncologica 46(3). p.286-307
Abstract
The Nordic countries have a long tradition of large-scale biobanking and comprehensive, population-based health data registries linkable on unique personal identifiers, enabling follow-up studies spanning many decades. Joint Nordic biobank-based studies provide unique opportunities for longitudinal molecular epidemiological research. The purpose of the present paper is to describe the possibilities for such joint studies, by describing some of the major Nordic biobank cohorts with a standardised calculation of the cancer incidence in these cohorts. Altogether two million donors have since 1966 donated more than four million biological samples, stored at -20 degrees C to -135 degrees C, to 17 biobank cohorts in Finland, Iceland, Norway and... (More)
The Nordic countries have a long tradition of large-scale biobanking and comprehensive, population-based health data registries linkable on unique personal identifiers, enabling follow-up studies spanning many decades. Joint Nordic biobank-based studies provide unique opportunities for longitudinal molecular epidemiological research. The purpose of the present paper is to describe the possibilities for such joint studies, by describing some of the major Nordic biobank cohorts with a standardised calculation of the cancer incidence in these cohorts. Altogether two million donors have since 1966 donated more than four million biological samples, stored at -20 degrees C to -135 degrees C, to 17 biobank cohorts in Finland, Iceland, Norway and Sweden. As a result of joint database handling principles, the accuracy of personal identifiers and completeness of follow-up for vital status in all participating biobanks was improved. Thereafter, the cancer incidence was determined using follow-up through the national cancer registries. Biobanks based on random samples of population typically showed slightly lower cancer incidence rates than the general population, presumably due to better participation rates among health-conscious subjects. On the other hand, biobanks including samples for viral screening or clinical testing showed 1.5 to 2.1 fold increased incidence of cancer. This excess was very high immediately after sampling, but for some cancer sites remained elevated for years after clinical sampling. So far, more than 100 000 malignant neoplasms have occurred after sample donation, and the annual increase of the cancer cases in these cohorts is about 10 000. The estimates on the population-representativity of the biobanks will assist in interpretation of generalizability of results of future studies based on these samples, and the systematic tabulations of numbers of cancer cases will serve in study power estimations. The present paper summarizes optimal study designs of biobank-based studies of cancer. (Less)
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Acta Oncologica
volume
46
issue
3
pages
286 - 307
publisher
Taylor & Francis
external identifiers
  • wos:000246336600002
  • scopus:34247219756
ISSN
1651-226X
DOI
10.1080/02841860701203545
language
English
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yes
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9eb54577-ef9e-44e2-9a16-ccf4cf142c64 (old id 662838)
date added to LUP
2007-12-20 08:08:52
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2017-08-13 04:21:48
@article{9eb54577-ef9e-44e2-9a16-ccf4cf142c64,
  abstract     = {The Nordic countries have a long tradition of large-scale biobanking and comprehensive, population-based health data registries linkable on unique personal identifiers, enabling follow-up studies spanning many decades. Joint Nordic biobank-based studies provide unique opportunities for longitudinal molecular epidemiological research. The purpose of the present paper is to describe the possibilities for such joint studies, by describing some of the major Nordic biobank cohorts with a standardised calculation of the cancer incidence in these cohorts. Altogether two million donors have since 1966 donated more than four million biological samples, stored at -20 degrees C to -135 degrees C, to 17 biobank cohorts in Finland, Iceland, Norway and Sweden. As a result of joint database handling principles, the accuracy of personal identifiers and completeness of follow-up for vital status in all participating biobanks was improved. Thereafter, the cancer incidence was determined using follow-up through the national cancer registries. Biobanks based on random samples of population typically showed slightly lower cancer incidence rates than the general population, presumably due to better participation rates among health-conscious subjects. On the other hand, biobanks including samples for viral screening or clinical testing showed 1.5 to 2.1 fold increased incidence of cancer. This excess was very high immediately after sampling, but for some cancer sites remained elevated for years after clinical sampling. So far, more than 100 000 malignant neoplasms have occurred after sample donation, and the annual increase of the cancer cases in these cohorts is about 10 000. The estimates on the population-representativity of the biobanks will assist in interpretation of generalizability of results of future studies based on these samples, and the systematic tabulations of numbers of cancer cases will serve in study power estimations. The present paper summarizes optimal study designs of biobank-based studies of cancer.},
  author       = {Pukkala, Eero and Andersen, Aage and Berglund, Göran and Gislefoss, Randi and Gudnason, Vilmundur and Hallmans, Goran and Jellum, Egil and Jousilahti, Pekka and Knekt, Paul and Koskela, Pentti and Kyyronen, P. Pentti and Lenner, Per and Luostarinen, Tapio and Love, Arthur and Ogmundsdottir, Helga and Stattin, Par and Tenkanen, Leena and Tryggvadottir, Laufey and Virtamo, Jarmo and Wadell, Goran and Widell, Anders and Lehtinen, Matti and Dillner, Joakim},
  issn         = {1651-226X},
  language     = {eng},
  number       = {3},
  pages        = {286--307},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Nordic biological specimen banks as basis for studies of cancer causes and control - more than 2 million sample donors, 25 million person years and 100 000 prospective cancers},
  url          = {http://dx.doi.org/10.1080/02841860701203545},
  volume       = {46},
  year         = {2007},
}