Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease
(2007) In Stroke: a journal of cerebral circulation 38(5). p.1495-1500- Abstract
- Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751... (More)
- Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751 individuals participating in the BCAPS. Carotid IMT was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. Results - Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of carotid disease both at 18 ( r = 0.09, P < 0.05) and 36 months ( r = 0.12, P < 0.005). At 36 months, the difference in IMT progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm ( 95% CI = 0.005 to 0.018 mm, P < 0.0001). Treatment with fluvastatin markedly decreased the progression of IMT among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and carotid IMT progression. Conclusions - IgM against the aldehyde-modified peptide corresponding amino acids 3136 and 3155 in apo B-100 is common in subjects with asymptomatic carotid disease, and high levels are associated with a more rapid progression of carotid IMT. The observation that the effect of fluvastatin was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/662883
- author
- Nordin Fredrikson, Gunilla LU ; Hedblad, Bo LU ; Berglund, Göran LU ; Alm, Ragnar LU ; Nilsson, Jan-Åke LU ; Schiopu, Alexandru LU ; Shah, Prediman K and Nilsson, Jan LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- carotid arteries, atherosclerosis, echocardiography, lipoproteins, immune system
- in
- Stroke: a journal of cerebral circulation
- volume
- 38
- issue
- 5
- pages
- 1495 - 1500
- publisher
- American Heart Association
- external identifiers
-
- wos:000245919500014
- scopus:34247553751
- ISSN
- 1524-4628
- DOI
- 10.1161/STROKEAHA.106.474577
- language
- English
- LU publication?
- yes
- id
- 0f925094-6c81-48f3-ad37-a4bdbd4c674e (old id 662883)
- date added to LUP
- 2016-04-01 16:07:51
- date last changed
- 2024-05-24 00:17:45
@article{0f925094-6c81-48f3-ad37-a4bdbd4c674e, abstract = {{Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751 individuals participating in the BCAPS. Carotid IMT was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. Results - Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of carotid disease both at 18 ( r = 0.09, P < 0.05) and 36 months ( r = 0.12, P < 0.005). At 36 months, the difference in IMT progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm ( 95% CI = 0.005 to 0.018 mm, P < 0.0001). Treatment with fluvastatin markedly decreased the progression of IMT among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and carotid IMT progression. Conclusions - IgM against the aldehyde-modified peptide corresponding amino acids 3136 and 3155 in apo B-100 is common in subjects with asymptomatic carotid disease, and high levels are associated with a more rapid progression of carotid IMT. The observation that the effect of fluvastatin was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group.}}, author = {{Nordin Fredrikson, Gunilla and Hedblad, Bo and Berglund, Göran and Alm, Ragnar and Nilsson, Jan-Åke and Schiopu, Alexandru and Shah, Prediman K and Nilsson, Jan}}, issn = {{1524-4628}}, keywords = {{carotid arteries; atherosclerosis; echocardiography; lipoproteins; immune system}}, language = {{eng}}, number = {{5}}, pages = {{1495--1500}}, publisher = {{American Heart Association}}, series = {{Stroke: a journal of cerebral circulation}}, title = {{Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease}}, url = {{http://dx.doi.org/10.1161/STROKEAHA.106.474577}}, doi = {{10.1161/STROKEAHA.106.474577}}, volume = {{38}}, year = {{2007}}, }