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Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease

Nordin Fredrikson, Gunilla LU ; Hedblad, Bo LU ; Berglund, Göran LU ; Alm, Ragnar LU ; Nilsson, Jan-Åke LU ; Schiopu, Alexandru LU ; Shah, Prediman K and Nilsson, Jan LU (2007) In Stroke: a journal of cerebral circulation 38(5). p.1495-1500
Abstract
Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751... (More)
Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751 individuals participating in the BCAPS. Carotid IMT was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. Results - Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of carotid disease both at 18 ( r = 0.09, P < 0.05) and 36 months ( r = 0.12, P < 0.005). At 36 months, the difference in IMT progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm ( 95% CI = 0.005 to 0.018 mm, P < 0.0001). Treatment with fluvastatin markedly decreased the progression of IMT among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and carotid IMT progression. Conclusions - IgM against the aldehyde-modified peptide corresponding amino acids 3136 and 3155 in apo B-100 is common in subjects with asymptomatic carotid disease, and high levels are associated with a more rapid progression of carotid IMT. The observation that the effect of fluvastatin was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
carotid arteries, atherosclerosis, echocardiography, lipoproteins, immune system
in
Stroke: a journal of cerebral circulation
volume
38
issue
5
pages
1495 - 1500
publisher
American Heart Association
external identifiers
  • wos:000245919500014
  • scopus:34247553751
ISSN
1524-4628
DOI
10.1161/STROKEAHA.106.474577
language
English
LU publication?
yes
id
0f925094-6c81-48f3-ad37-a4bdbd4c674e (old id 662883)
date added to LUP
2007-12-07 10:48:16
date last changed
2017-10-29 04:14:47
@article{0f925094-6c81-48f3-ad37-a4bdbd4c674e,
  abstract     = {Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751 individuals participating in the BCAPS. Carotid IMT was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. Results - Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of carotid disease both at 18 ( r = 0.09, P &lt; 0.05) and 36 months ( r = 0.12, P &lt; 0.005). At 36 months, the difference in IMT progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm ( 95% CI = 0.005 to 0.018 mm, P &lt; 0.0001). Treatment with fluvastatin markedly decreased the progression of IMT among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and carotid IMT progression. Conclusions - IgM against the aldehyde-modified peptide corresponding amino acids 3136 and 3155 in apo B-100 is common in subjects with asymptomatic carotid disease, and high levels are associated with a more rapid progression of carotid IMT. The observation that the effect of fluvastatin was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group.},
  author       = {Nordin Fredrikson, Gunilla and Hedblad, Bo and Berglund, Göran and Alm, Ragnar and Nilsson, Jan-Åke and Schiopu, Alexandru and Shah, Prediman K and Nilsson, Jan},
  issn         = {1524-4628},
  keyword      = {carotid arteries,atherosclerosis,echocardiography,lipoproteins,immune system},
  language     = {eng},
  number       = {5},
  pages        = {1495--1500},
  publisher    = {American Heart Association},
  series       = { Stroke: a journal of cerebral circulation},
  title        = {Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.106.474577},
  volume       = {38},
  year         = {2007},
}