Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years
(2020) In Osteoarthritis and Cartilage 28(3). p.356-362- Abstract
Objective: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years. Methods: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assessed 2 years post-injury. Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were assessed at 2 and 5 years. We used multiple imputation to handle biomarker values that were below the level of detection or missing, and linear regression for statistical analyses. Results: None of the synovial fluid cytokines or imaging biomarkers of... (More)
Objective: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years. Methods: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assessed 2 years post-injury. Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were assessed at 2 and 5 years. We used multiple imputation to handle biomarker values that were below the level of detection or missing, and linear regression for statistical analyses. Results: None of the synovial fluid cytokines or imaging biomarkers of inflammation at 2 years were associated with any of the patient-reported outcomes at 5 years. With each log10 unit higher of serum tumor necrosis factor concentration the knee-related quality of life of KOOS was increased (i.e., better outcome) by 35 (95% confidence interval 7 to 63) points. No other serum biomarker measured at 2 years was associated with patient-reported outcome at 5 years. Conclusion: Local joint inflammation assessed by biomarkers in synovial fluid and Hoffa- and effusion-synovitis on MRI at 2 years after an ACL injury did not associate with patient-reported outcomes at 5 years. Thus, chronic inflammation in the ACL-injured knee, as reflected by the biomarkers studied here, seems not to be a key determinant for the long-term patient-reported outcomes.
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- author
- Struglics, A. LU ; Turkiewicz, A. LU ; Larsson, S. LU ; Lohmander, L. S. LU ; Roemer, F. W. LU ; Frobell, R. LU and Englund, M. LU
- organization
- publishing date
- 2020-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anterior cruciate ligament injury, Biomarkers, Inflammation, Patient reported outcomes, Synovitis
- in
- Osteoarthritis and Cartilage
- volume
- 28
- issue
- 3
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85078809192
- pmid:31940458
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2019.12.010
- language
- English
- LU publication?
- yes
- id
- 662de9dd-04c3-4840-9eda-0014e626c763
- date added to LUP
- 2020-02-18 12:38:51
- date last changed
- 2024-03-04 14:02:39
@article{662de9dd-04c3-4840-9eda-0014e626c763, abstract = {{<p>Objective: To estimate the association between molecular or imaging inflammatory biomarkers at 2 years after anterior cruciate ligament (ACL) injury and patient-reported outcomes at 5 years. Methods: For 116 ACL-injured patients, molecular biomarkers of inflammation (synovial fluid and serum cytokines) and Hoffa- and effusion-synovitis as visualized on magnetic resonance imaging (MRI) were assessed 2 years post-injury. Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were assessed at 2 and 5 years. We used multiple imputation to handle biomarker values that were below the level of detection or missing, and linear regression for statistical analyses. Results: None of the synovial fluid cytokines or imaging biomarkers of inflammation at 2 years were associated with any of the patient-reported outcomes at 5 years. With each log10 unit higher of serum tumor necrosis factor concentration the knee-related quality of life of KOOS was increased (i.e., better outcome) by 35 (95% confidence interval 7 to 63) points. No other serum biomarker measured at 2 years was associated with patient-reported outcome at 5 years. Conclusion: Local joint inflammation assessed by biomarkers in synovial fluid and Hoffa- and effusion-synovitis on MRI at 2 years after an ACL injury did not associate with patient-reported outcomes at 5 years. Thus, chronic inflammation in the ACL-injured knee, as reflected by the biomarkers studied here, seems not to be a key determinant for the long-term patient-reported outcomes.</p>}}, author = {{Struglics, A. and Turkiewicz, A. and Larsson, S. and Lohmander, L. S. and Roemer, F. W. and Frobell, R. and Englund, M.}}, issn = {{1063-4584}}, keywords = {{Anterior cruciate ligament injury; Biomarkers; Inflammation; Patient reported outcomes; Synovitis}}, language = {{eng}}, month = {{03}}, number = {{3}}, pages = {{356--362}}, publisher = {{Elsevier}}, series = {{Osteoarthritis and Cartilage}}, title = {{Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years}}, url = {{http://dx.doi.org/10.1016/j.joca.2019.12.010}}, doi = {{10.1016/j.joca.2019.12.010}}, volume = {{28}}, year = {{2020}}, }