Advanced

Risk factors for positive tuberculin skin test in Guinea-Bissau

Gustafson, Per LU ; Lisse, Ida; Gomes, Victor; Vieira, Cesaltina S.; Lienhardt, Christian; Nauclér, Anders LU ; Jensen, Henrik and Aaby, Peter (2007) In Epidemiology 18(3). p.340-347
Abstract
Background: The tuberculin skin test is used for tracing of tuberculosis transmission and identifying individuals in need of prophylactic treatment. Methods: Using a case-control study design, we recruited 220 smear-positive tuberculosis cases and 223 randomly selected healthy community controls in Bissau, Guinea-Bissau, during 1999-2000. Tuberculin skin tests were performed on family members of cases and controls (n = 1059 and n = 92 1, respectively). Induration of 10 mm or greater was considered positive. Risk factors were calculated for children (< 15 years) and adults separately in multivariate logistic regression analysis. Results: The prevalence of positive tuberculin skin test was 41% in case-contacts compared with 22% in... (More)
Background: The tuberculin skin test is used for tracing of tuberculosis transmission and identifying individuals in need of prophylactic treatment. Methods: Using a case-control study design, we recruited 220 smear-positive tuberculosis cases and 223 randomly selected healthy community controls in Bissau, Guinea-Bissau, during 1999-2000. Tuberculin skin tests were performed on family members of cases and controls (n = 1059 and n = 92 1, respectively). Induration of 10 mm or greater was considered positive. Risk factors were calculated for children (< 15 years) and adults separately in multivariate logistic regression analysis. Results: The prevalence of positive tuberculin skin test was 41% in case-contacts compared with 22% in control-contacts, resulting in a prevalence ratio of 1.48 (95% confidence interval = 1.37-1.60). Positive skin tests among case-contacts increased with age for children, as well as with proximity to a case during the night, for both children and adults. A Bacille Calmette Guerin scar increased the likelihood of having a positive tuberculin skin test for adults in case households, but not in other categories of contacts. Among control-contacts the prevalence of positive skin test was associated with older age in children, history of tuberculosis in the family, and a positive tuberculin skin test of the control person. Conclusions: Risk factors for a positive tuberculin skin test among case- and control-contacts are closely related to tuberculosis exposure. Having a BCG scar did not increase the risk of positive skin test in unexposed individuals. Tuberculin skin testing remains a useful tool for diagnosing tuberculosis infection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Epidemiology
volume
18
issue
3
pages
340 - 347
publisher
Wolters Kluwer Health/LWW
external identifiers
  • wos:000245993300007
  • scopus:34247251473
ISSN
1531-5487
DOI
10.1097/01.ede.0000259987.46912.2b
language
English
LU publication?
yes
id
7517c151-f643-44ef-87a3-d8986b6135df (old id 663625)
date added to LUP
2007-12-10 15:57:36
date last changed
2017-07-23 03:48:43
@article{7517c151-f643-44ef-87a3-d8986b6135df,
  abstract     = {Background: The tuberculin skin test is used for tracing of tuberculosis transmission and identifying individuals in need of prophylactic treatment. Methods: Using a case-control study design, we recruited 220 smear-positive tuberculosis cases and 223 randomly selected healthy community controls in Bissau, Guinea-Bissau, during 1999-2000. Tuberculin skin tests were performed on family members of cases and controls (n = 1059 and n = 92 1, respectively). Induration of 10 mm or greater was considered positive. Risk factors were calculated for children (&lt; 15 years) and adults separately in multivariate logistic regression analysis. Results: The prevalence of positive tuberculin skin test was 41% in case-contacts compared with 22% in control-contacts, resulting in a prevalence ratio of 1.48 (95% confidence interval = 1.37-1.60). Positive skin tests among case-contacts increased with age for children, as well as with proximity to a case during the night, for both children and adults. A Bacille Calmette Guerin scar increased the likelihood of having a positive tuberculin skin test for adults in case households, but not in other categories of contacts. Among control-contacts the prevalence of positive skin test was associated with older age in children, history of tuberculosis in the family, and a positive tuberculin skin test of the control person. Conclusions: Risk factors for a positive tuberculin skin test among case- and control-contacts are closely related to tuberculosis exposure. Having a BCG scar did not increase the risk of positive skin test in unexposed individuals. Tuberculin skin testing remains a useful tool for diagnosing tuberculosis infection.},
  author       = {Gustafson, Per and Lisse, Ida and Gomes, Victor and Vieira, Cesaltina S. and Lienhardt, Christian and Nauclér, Anders and Jensen, Henrik and Aaby, Peter},
  issn         = {1531-5487},
  language     = {eng},
  number       = {3},
  pages        = {340--347},
  publisher    = {Wolters Kluwer Health/LWW},
  series       = {Epidemiology},
  title        = {Risk factors for positive tuberculin skin test in Guinea-Bissau},
  url          = {http://dx.doi.org/10.1097/01.ede.0000259987.46912.2b},
  volume       = {18},
  year         = {2007},
}