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Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis

Johnsson, Richard LU ; Mani, Katrin LU and Ellervik, Ulf LU (2007) In Bioorganic & Medicinal Chemistry Letters 17(8). p.2338-2341
Abstract
A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glycosaminoglycan, fluorescent, carbohydrates, xylose, proteoglycan
in
Bioorganic & Medicinal Chemistry Letters
volume
17
issue
8
pages
2338 - 2341
publisher
Elsevier
external identifiers
  • wos:000246045900045
  • scopus:33947683396
  • pmid:17291749
ISSN
0960-894X
DOI
10.1016/j.bmcl.2007.01.063
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Glycobiology (013212006)
id
5b270ca6-7742-4b50-91ba-88e4f93b5c4c (old id 663688)
date added to LUP
2016-04-01 11:34:56
date last changed
2020-01-12 08:12:42
@article{5b270ca6-7742-4b50-91ba-88e4f93b5c4c,
  abstract     = {A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.},
  author       = {Johnsson, Richard and Mani, Katrin and Ellervik, Ulf},
  issn         = {0960-894X},
  language     = {eng},
  number       = {8},
  pages        = {2338--2341},
  publisher    = {Elsevier},
  series       = {Bioorganic & Medicinal Chemistry Letters},
  title        = {Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis},
  url          = {http://dx.doi.org/10.1016/j.bmcl.2007.01.063},
  doi          = {10.1016/j.bmcl.2007.01.063},
  volume       = {17},
  year         = {2007},
}