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Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis

Johnsson, Richard LU ; Mani, Katrin LU and Ellervik, Ulf LU (2007) In Bioorganic & Medicinal Chemistry Letters 17(8). p.2338-2341
Abstract
A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glycosaminoglycan, fluorescent, carbohydrates, xylose, proteoglycan
in
Bioorganic & Medicinal Chemistry Letters
volume
17
issue
8
pages
2338 - 2341
publisher
Elsevier
external identifiers
  • wos:000246045900045
  • scopus:33947683396
ISSN
1090-2120
DOI
10.1016/j.bmcl.2007.01.063
language
English
LU publication?
yes
id
5b270ca6-7742-4b50-91ba-88e4f93b5c4c (old id 663688)
date added to LUP
2007-12-13 13:57:26
date last changed
2017-01-01 04:20:54
@article{5b270ca6-7742-4b50-91ba-88e4f93b5c4c,
  abstract     = {A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.},
  author       = {Johnsson, Richard and Mani, Katrin and Ellervik, Ulf},
  issn         = {1090-2120},
  keyword      = {glycosaminoglycan,fluorescent,carbohydrates,xylose,proteoglycan},
  language     = {eng},
  number       = {8},
  pages        = {2338--2341},
  publisher    = {Elsevier},
  series       = {Bioorganic & Medicinal Chemistry Letters},
  title        = {Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis},
  url          = {http://dx.doi.org/10.1016/j.bmcl.2007.01.063},
  volume       = {17},
  year         = {2007},
}