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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, Richa; Voight, Benjamin F.; Lyssenko, Valeriya LU ; Burtt, Noel P.; de Bakker, Paul I. W.; Chen, Hong; Roix, Jeffrey J.; Kathiresan, Sekar; Hirschhorn, Joel N. and Daly, Mark J., et al. (2007) In Science 316(5829). p.1331-1336
Abstract
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum... (More)
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
316
issue
5829
pages
1331 - 1336
publisher
The American Association for the Advancement of Science
external identifiers
  • wos:000246885600049
  • scopus:34249888775
ISSN
1095-9203
DOI
10.1126/science.1142358
language
English
LU publication?
yes
id
4c3f4bd1-ec53-4b36-a53c-564bc07ba43c (old id 663952)
date added to LUP
2007-12-14 14:27:51
date last changed
2017-11-19 04:12:56
@article{4c3f4bd1-ec53-4b36-a53c-564bc07ba43c,
  abstract     = {New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.},
  author       = {Saxena, Richa and Voight, Benjamin F. and Lyssenko, Valeriya and Burtt, Noel P. and de Bakker, Paul I. W. and Chen, Hong and Roix, Jeffrey J. and Kathiresan, Sekar and Hirschhorn, Joel N. and Daly, Mark J. and Hughes, Thomas E. and Groop, Leif and Altshuler, David and Almgren, Peter and Florez, Jose C. and Meyer, Joanne and Ardlie, Kristin and Bengtsson Boström, Kristina and Isomaa, Bo and Lettre, Guillaume and Lindblad, Ulf and Lyon, Helen N. and Melander, Olle and Newton-Cheh, Christopher and Nilsson, Peter and Orho-Melander, Marju and Råstam, Lennart and Speliotes, Elizabeth K. and Taskinen, Marja-Riitta and Tuomi, Tiinamaija and Guiducci, Candace and Berglund, Anna and Carlson, Joyce and Gianniny, Lauren and Hackett, Rachel and Hall, Liselotte and Holmkvist, Johan and Laurila, Esa and Sjögren, Marketa and Sterner, Maria and Surti, Aarti and Svensson, Margareta and Svensson, Malin and Tewhey, Ryan and Blumenstiel, Brendan and Parkin, Melissa and DeFelice, Matthew and Barry, Rachel and Brodeur, Wendy and Camarata, Jody and Chia, Nancy and Fava, Mary and Gibbons, John and Handsaker, Bob and Healy, Claire and Nguyen, Kieu and Gates, Casey and Sougnez, Carrie and Gage, Diane and Nizzari, Marcia and Gabriel, Stacey B. and Chirn, Gung-Wei and Ma, Qicheng and Parikh, Hemang and Richardson, Delwood and Ricke, Darrell and Purcell, Shaun},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5829},
  pages        = {1331--1336},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science},
  title        = {Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels},
  url          = {http://dx.doi.org/10.1126/science.1142358},
  volume       = {316},
  year         = {2007},
}