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Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve

Gustavsson, Per LU ; Eriksson Linsmeier, Cecilia LU ; Leffler, Hakon LU and Kanje, Martin LU (2007) In NeuroReport 18(7). p.669-673
Abstract
The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is... (More)
The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Wallerian degeneration, sciatic, Schwann cells, proliferation, in vitro, galectin-3, injury, nerve
in
NeuroReport
volume
18
issue
7
pages
669 - 673
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000245856000010
  • scopus:34247225952
ISSN
1473-558X
language
English
LU publication?
yes
id
700c0159-9cbc-44c7-8a43-fee24eb6b569 (old id 664467)
alternative location
http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200705070-00010.htm
date added to LUP
2007-12-12 08:59:44
date last changed
2017-01-01 04:51:51
@article{700c0159-9cbc-44c7-8a43-fee24eb6b569,
  abstract     = {The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety.},
  author       = {Gustavsson, Per and Eriksson Linsmeier, Cecilia and Leffler, Hakon and Kanje, Martin},
  issn         = {1473-558X},
  keyword      = {Wallerian degeneration,sciatic,Schwann cells,proliferation,in vitro,galectin-3,injury,nerve},
  language     = {eng},
  number       = {7},
  pages        = {669--673},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve},
  volume       = {18},
  year         = {2007},
}