Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve
(2007) In NeuroReport 18(7). p.669-673- Abstract
- The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is... (More)
- The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/664467
- author
- Gustavsson, Per LU ; Eriksson Linsmeier, Cecilia LU ; Leffler, Hakon LU and Kanje, Martin LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Wallerian degeneration, sciatic, Schwann cells, proliferation, in vitro, galectin-3, injury, nerve
- in
- NeuroReport
- volume
- 18
- issue
- 7
- pages
- 669 - 673
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000245856000010
- scopus:34247225952
- ISSN
- 1473-558X
- language
- English
- LU publication?
- yes
- id
- 700c0159-9cbc-44c7-8a43-fee24eb6b569 (old id 664467)
- alternative location
- http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200705070-00010.htm
- date added to LUP
- 2016-04-01 12:07:51
- date last changed
- 2022-01-26 23:14:05
@article{700c0159-9cbc-44c7-8a43-fee24eb6b569,
abstract = {{The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety.}},
author = {{Gustavsson, Per and Eriksson Linsmeier, Cecilia and Leffler, Hakon and Kanje, Martin}},
issn = {{1473-558X}},
keywords = {{Wallerian degeneration; sciatic; Schwann cells; proliferation; in vitro; galectin-3; injury; nerve}},
language = {{eng}},
number = {{7}},
pages = {{669--673}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve}},
url = {{http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200705070-00010.htm}},
volume = {{18}},
year = {{2007}},
}