Impaired nerve regeneration and Schwann cell activation after repair with tension.
Yi, Chuanjun LU and Dahlin, Lars LU
(2010)
In NeuroReport
21.
p.958-962
- Abstract
- The aim was to investigate the relation between axonal outgrowth (neurofilaments) and Schwann cell activation (activating transcription factor 3) and apoptosis (caspase 3) 10 days after nerve repair with no, minor (3 mm defect) and moderate (6 mm defect) tension in rat sciatic nerve using immunohistochemistry. After repair with no tension, axons grew 11.75 mm, but repair with minor and moderate tension impaired axonal outgrowth by 29 and 48%, respectively, with a reduced number of activating transcription factor 3 stained and an increased number of caspase 3 stained Schwann cells. Axonal outgrowth correlated with activation of and inversely with apoptosis of Schwann cells. Tension induces impaired activation of Schwann cells, and a higher... (More)
- The aim was to investigate the relation between axonal outgrowth (neurofilaments) and Schwann cell activation (activating transcription factor 3) and apoptosis (caspase 3) 10 days after nerve repair with no, minor (3 mm defect) and moderate (6 mm defect) tension in rat sciatic nerve using immunohistochemistry. After repair with no tension, axons grew 11.75 mm, but repair with minor and moderate tension impaired axonal outgrowth by 29 and 48%, respectively, with a reduced number of activating transcription factor 3 stained and an increased number of caspase 3 stained Schwann cells. Axonal outgrowth correlated with activation of and inversely with apoptosis of Schwann cells. Tension induces impaired activation of Schwann cells, and a higher amount of apoptotic Schwann cells, with a subsequent deteriorated axonal outgrowth. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1665094
- author
- Yi, Chuanjun
LU
and Dahlin, Lars
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- NeuroReport
- volume
- 21
- pages
- 958 - 962
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000281816700011
- pmid:20729767
- scopus:77956419526
- pmid:20729767
- ISSN
- 1473-558X
- DOI
- 10.1097/WNR.0b013e32833e787f
- language
- English
- LU publication?
- yes
- id
- 66609a6d-a984-4c67-9ec8-f8bfbeddad6b (old id 1665094)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20729767?dopt=Abstract
- date added to LUP
- 2016-04-04 08:36:46
- date last changed
- 2022-03-23 02:37:01
@article{66609a6d-a984-4c67-9ec8-f8bfbeddad6b,
abstract = {{The aim was to investigate the relation between axonal outgrowth (neurofilaments) and Schwann cell activation (activating transcription factor 3) and apoptosis (caspase 3) 10 days after nerve repair with no, minor (3 mm defect) and moderate (6 mm defect) tension in rat sciatic nerve using immunohistochemistry. After repair with no tension, axons grew 11.75 mm, but repair with minor and moderate tension impaired axonal outgrowth by 29 and 48%, respectively, with a reduced number of activating transcription factor 3 stained and an increased number of caspase 3 stained Schwann cells. Axonal outgrowth correlated with activation of and inversely with apoptosis of Schwann cells. Tension induces impaired activation of Schwann cells, and a higher amount of apoptotic Schwann cells, with a subsequent deteriorated axonal outgrowth.}},
author = {{Yi, Chuanjun and Dahlin, Lars}},
issn = {{1473-558X}},
language = {{eng}},
pages = {{958--962}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{Impaired nerve regeneration and Schwann cell activation after repair with tension.}},
url = {{http://dx.doi.org/10.1097/WNR.0b013e32833e787f}},
doi = {{10.1097/WNR.0b013e32833e787f}},
volume = {{21}},
year = {{2010}},
}