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OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas

Reeve, Janice L. V.; Stenson-Cox, Catherine; O'Doherty, Aideen; Porn-Ares, Isabella; Ares, Mikko LU ; O'Brien, Timothy and Samali, Afshin (2007) In Biochemical and Biophysical Research Communications 356(3). p.681-686
Abstract
Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights... (More)
Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
smooth muscle cell, OxLDL, oxidative stress, gene expression, apolipoprotein E, cell death
in
Biochemical and Biophysical Research Communications
volume
356
issue
3
pages
681 - 686
publisher
Elsevier
external identifiers
  • wos:000245740900026
  • scopus:33947612566
ISSN
1090-2104
DOI
10.1016/j.bbrc.2007.03.027
language
English
LU publication?
yes
id
4efaea02-c938-4d2b-b4db-1454840b2604 (old id 666171)
date added to LUP
2007-12-18 10:54:25
date last changed
2017-06-25 04:28:11
@article{4efaea02-c938-4d2b-b4db-1454840b2604,
  abstract     = {Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.},
  author       = {Reeve, Janice L. V. and Stenson-Cox, Catherine and O'Doherty, Aideen and Porn-Ares, Isabella and Ares, Mikko and O'Brien, Timothy and Samali, Afshin},
  issn         = {1090-2104},
  keyword      = {smooth muscle cell,OxLDL,oxidative stress,gene expression,apolipoprotein E,cell death},
  language     = {eng},
  number       = {3},
  pages        = {681--686},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2007.03.027},
  volume       = {356},
  year         = {2007},
}