OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas
(2007) In Biochemical and Biophysical Research Communications 356(3). p.681-686- Abstract
- Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights... (More)
- Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/666171
- author
- Reeve, Janice L. V. ; Stenson-Cox, Catherine ; O'Doherty, Aideen ; Porn-Ares, Isabella ; Ares, Mikko LU ; O'Brien, Timothy and Samali, Afshin
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- smooth muscle cell, OxLDL, oxidative stress, gene expression, apolipoprotein E, cell death
- in
- Biochemical and Biophysical Research Communications
- volume
- 356
- issue
- 3
- pages
- 681 - 686
- publisher
- Elsevier
- external identifiers
-
- wos:000245740900026
- scopus:33947612566
- ISSN
- 1090-2104
- DOI
- 10.1016/j.bbrc.2007.03.027
- language
- English
- LU publication?
- yes
- id
- 4efaea02-c938-4d2b-b4db-1454840b2604 (old id 666171)
- date added to LUP
- 2016-04-01 16:42:41
- date last changed
- 2022-01-28 21:34:06
@article{4efaea02-c938-4d2b-b4db-1454840b2604,
abstract = {{Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.}},
author = {{Reeve, Janice L. V. and Stenson-Cox, Catherine and O'Doherty, Aideen and Porn-Ares, Isabella and Ares, Mikko and O'Brien, Timothy and Samali, Afshin}},
issn = {{1090-2104}},
keywords = {{smooth muscle cell; OxLDL; oxidative stress; gene expression; apolipoprotein E; cell death}},
language = {{eng}},
number = {{3}},
pages = {{681--686}},
publisher = {{Elsevier}},
series = {{Biochemical and Biophysical Research Communications}},
title = {{OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas}},
url = {{http://dx.doi.org/10.1016/j.bbrc.2007.03.027}},
doi = {{10.1016/j.bbrc.2007.03.027}},
volume = {{356}},
year = {{2007}},
}