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Patient characteristics associated with quality of life in European women seeking treatment for urinary incontinence: Results from PURE

Monz, Brigitta; Chartier-Kastier, Emmanuel; Hampel, Christian; Samsioe, Göran LU ; Hunskaar, Steinar; Espuna-Pons, Montserrat; Wagg, Adrian; Quail, Deborah; Castro, Ramiro and Chinn, Chris (2007) In European Urology 51(4). p.1073-1082
Abstract
Objective: To investigate the association between patient characteristics and disease-specific and generic quality of life (QOL) as well as the degree of bother in women seeking treatment for urinary incontinence (UI). Methods: The Prospective Urinary Incontinence Research (PURE) was a 6-mo observational study with 1055 physicians from 15 European countries enrolling 9487 women. QOL was assessed at the enrolment visit using the urinary Incontinence Quality of Life questionnaire (I-QOL) and the generic EQ-5D. A single-item instrument was used to measure the degree of bother. UI severity was assessed using the Sandvik index. UI was categorised into stress (SUI), mixed (MUI), and urge (UUI) urinary incontinence by a patient-administered... (More)
Objective: To investigate the association between patient characteristics and disease-specific and generic quality of life (QOL) as well as the degree of bother in women seeking treatment for urinary incontinence (UI). Methods: The Prospective Urinary Incontinence Research (PURE) was a 6-mo observational study with 1055 physicians from 15 European countries enrolling 9487 women. QOL was assessed at the enrolment visit using the urinary Incontinence Quality of Life questionnaire (I-QOL) and the generic EQ-5D. A single-item instrument was used to measure the degree of bother. UI severity was assessed using the Sandvik index. UI was categorised into stress (SUI), mixed (MUI), and urge (UUI) urinary incontinence by a patient-administered instrument (Stress and Urge Incontinence Questionnaire [S/UIQ]). Multivariate linear (I-QOL, EQ-5D Visual Analogue Scale) and logistic (bother, EQ-5D health state index) regressions were performed. Results: Mean total I-QOL scores were significantly and independently associated with UI severity, nocturia, age, UI subtype, number of selected concomitant medical conditions, length of suffering from UI before contacting a doctor, smoking status, ongoing use of UI medication, and country. After adjusting for all the covariates, the total I-QOL scores for SUI, MUI, and UUI were 62.7, 53.8 and 60.1, respectively. As with I-QOL, UI severity was also the most important predictor for bother. The number of concomitant medical conditions, together with UI severity, was the variable most strongly associated with EQ-5D. Conclusion: In addition to the UI subtypes, severity of UI should be given more importance in treatment algorithms and in treatment decision-making by both the patient and the physician. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
female urinary incontinence, European, bother, EQ-5D, I-QOL, PURE, quality of life
in
European Urology
volume
51
issue
4
pages
1073 - 1082
publisher
Elsevier
external identifiers
  • wos:000245310600028
  • scopus:33847184935
ISSN
1873-7560
DOI
10.1016/j.eururo.2006.09.022
language
English
LU publication?
yes
id
9ef72a3d-8915-45b7-86e8-666524db0af8 (old id 668516)
date added to LUP
2007-12-18 12:10:37
date last changed
2017-11-05 04:39:01
@article{9ef72a3d-8915-45b7-86e8-666524db0af8,
  abstract     = {Objective: To investigate the association between patient characteristics and disease-specific and generic quality of life (QOL) as well as the degree of bother in women seeking treatment for urinary incontinence (UI). Methods: The Prospective Urinary Incontinence Research (PURE) was a 6-mo observational study with 1055 physicians from 15 European countries enrolling 9487 women. QOL was assessed at the enrolment visit using the urinary Incontinence Quality of Life questionnaire (I-QOL) and the generic EQ-5D. A single-item instrument was used to measure the degree of bother. UI severity was assessed using the Sandvik index. UI was categorised into stress (SUI), mixed (MUI), and urge (UUI) urinary incontinence by a patient-administered instrument (Stress and Urge Incontinence Questionnaire [S/UIQ]). Multivariate linear (I-QOL, EQ-5D Visual Analogue Scale) and logistic (bother, EQ-5D health state index) regressions were performed. Results: Mean total I-QOL scores were significantly and independently associated with UI severity, nocturia, age, UI subtype, number of selected concomitant medical conditions, length of suffering from UI before contacting a doctor, smoking status, ongoing use of UI medication, and country. After adjusting for all the covariates, the total I-QOL scores for SUI, MUI, and UUI were 62.7, 53.8 and 60.1, respectively. As with I-QOL, UI severity was also the most important predictor for bother. The number of concomitant medical conditions, together with UI severity, was the variable most strongly associated with EQ-5D. Conclusion: In addition to the UI subtypes, severity of UI should be given more importance in treatment algorithms and in treatment decision-making by both the patient and the physician. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved.},
  author       = {Monz, Brigitta and Chartier-Kastier, Emmanuel and Hampel, Christian and Samsioe, Göran and Hunskaar, Steinar and Espuna-Pons, Montserrat and Wagg, Adrian and Quail, Deborah and Castro, Ramiro and Chinn, Chris},
  issn         = {1873-7560},
  keyword      = {female urinary incontinence,European,bother,EQ-5D,I-QOL,PURE,quality of life},
  language     = {eng},
  number       = {4},
  pages        = {1073--1082},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Patient characteristics associated with quality of life in European women seeking treatment for urinary incontinence: Results from PURE},
  url          = {http://dx.doi.org/10.1016/j.eururo.2006.09.022},
  volume       = {51},
  year         = {2007},
}