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Gender-specific links between hepatic 11 beta reduction of cortisone and adipokines

Mattsson, Cecilia; Rask, Eva; Carlstroem, Kjell; Andersson, Jonas; Eliasson, Mats; Ahrén, Bo LU ; Soederberg, Stefan and Olsson, Tommy (2007) In Obesity Research 15(4). p.887-894
Abstract
Objective: Reduction of cortisone to cortisol is mediated by 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta HSD1), a putative key enzyme in obesity-related complications. Experimental studies suggest that adipokines, notably leptin and tumor necrosis factor-alpha (TNF-alpha), are of importance for 11 beta HSD1 activity. We hypothesized that the regulation of hepatic preceptor glucocorticoid metabolism is gender-specific and associated with circulating levels of leptin and TNF-a receptors and/or sex hormones. Research Methods and Procedures: A total of 34 males and 38 women (14 premenopausal and 22 postmenopausal) underwent physical examination and fasting blood Sampling. Insulin sensitivity was tested by euglycemic hyperinsulinemic... (More)
Objective: Reduction of cortisone to cortisol is mediated by 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta HSD1), a putative key enzyme in obesity-related complications. Experimental studies suggest that adipokines, notably leptin and tumor necrosis factor-alpha (TNF-alpha), are of importance for 11 beta HSD1 activity. We hypothesized that the regulation of hepatic preceptor glucocorticoid metabolism is gender-specific and associated with circulating levels of leptin and TNF-a receptors and/or sex hormones. Research Methods and Procedures: A total of 34 males and 38 women (14 premenopausal and 22 postmenopausal) underwent physical examination and fasting blood Sampling. Insulin sensitivity was tested by euglycemic hyperinsulinemic clamps, and hepatic 11 beta HSD1 enzyme activity was estimated by the conversion of orally-ingested cortisone to cortisol. Results: Hepatic 11 beta HSD1 activity was negatively associated with leptin and soluble TNF (sTNF) r1 and sTNFr2 in males. These correlations remained significant after adjustment for age and insulin sensitivity, and for sTNF-alpha receptors also after adjustment of BMI and waist circumference. In contrast, 11 beta reduction of cortisone was positively associated to leptin in females after adjustment for BMI and waist circumference. Discussion: Hepatic 11 beta reduction shows different links to circulating adipocyte-derived hormones in males and females. This emphasizes the need for further studies on tissue-specific regulation of 11 beta HSD1 in both genders. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adipocytokines, 11 beta-hydroxysteroid dehydrogenase type 1, liver, insulin sensitivity, gender
in
Obesity Research
volume
15
issue
4
pages
887 - 894
publisher
The North American Association for the Study of Obesity
external identifiers
  • wos:000245729300014
ISSN
1071-7323
language
English
LU publication?
yes
id
6988a3b3-1e82-4c3b-8142-d0b5ca09242d (old id 669251)
alternative location
http://www.obesityresearch.org/cgi/content/abstract/15/4/887
date added to LUP
2007-12-13 16:51:28
date last changed
2016-04-16 03:28:01
@article{6988a3b3-1e82-4c3b-8142-d0b5ca09242d,
  abstract     = {Objective: Reduction of cortisone to cortisol is mediated by 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta HSD1), a putative key enzyme in obesity-related complications. Experimental studies suggest that adipokines, notably leptin and tumor necrosis factor-alpha (TNF-alpha), are of importance for 11 beta HSD1 activity. We hypothesized that the regulation of hepatic preceptor glucocorticoid metabolism is gender-specific and associated with circulating levels of leptin and TNF-a receptors and/or sex hormones. Research Methods and Procedures: A total of 34 males and 38 women (14 premenopausal and 22 postmenopausal) underwent physical examination and fasting blood Sampling. Insulin sensitivity was tested by euglycemic hyperinsulinemic clamps, and hepatic 11 beta HSD1 enzyme activity was estimated by the conversion of orally-ingested cortisone to cortisol. Results: Hepatic 11 beta HSD1 activity was negatively associated with leptin and soluble TNF (sTNF) r1 and sTNFr2 in males. These correlations remained significant after adjustment for age and insulin sensitivity, and for sTNF-alpha receptors also after adjustment of BMI and waist circumference. In contrast, 11 beta reduction of cortisone was positively associated to leptin in females after adjustment for BMI and waist circumference. Discussion: Hepatic 11 beta reduction shows different links to circulating adipocyte-derived hormones in males and females. This emphasizes the need for further studies on tissue-specific regulation of 11 beta HSD1 in both genders.},
  author       = {Mattsson, Cecilia and Rask, Eva and Carlstroem, Kjell and Andersson, Jonas and Eliasson, Mats and Ahrén, Bo and Soederberg, Stefan and Olsson, Tommy},
  issn         = {1071-7323},
  keyword      = {adipocytokines,11 beta-hydroxysteroid dehydrogenase type 1,liver,insulin sensitivity,gender},
  language     = {eng},
  number       = {4},
  pages        = {887--894},
  publisher    = {The North American Association for the Study of Obesity},
  series       = {Obesity Research},
  title        = {Gender-specific links between hepatic 11 beta reduction of cortisone and adipokines},
  volume       = {15},
  year         = {2007},
}