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Effect of melatonin on age associated changes in guinea pig bladder function

Gomez-Pinilla, Pedro J.; Gomez, Maria LU ; Hedlund, Petter LU ; Swärd, Karl LU ; Hellstrand, Per LU ; Camello, Pedro J.; Pozo, Maria J. and Andersson, Karl-Erik LU (2007) In Journal of Urology 177(4). p.1558-1561
Abstract
Purpose: The incidence of urinary incontinence increases with age but the cause and effect relationship between aging and altered bladder function is poorly understood. It was suggested that melatonin can ameliorate negative effects induced by aging by its free radical scavenging activity and its ability to decrease oxidative stress. We investigated the changes in bladder function evoked by aging and the possible benefits of melatonin treatment on age related bladder disturbances. Materials and Methods: Bladder function was assessed using cystometry in conscious, freely moving female guinea pigs. Animals were grouped according to age as young adults (4 months old) and senescents (18 to 20 months old). A group of senescent animals were... (More)
Purpose: The incidence of urinary incontinence increases with age but the cause and effect relationship between aging and altered bladder function is poorly understood. It was suggested that melatonin can ameliorate negative effects induced by aging by its free radical scavenging activity and its ability to decrease oxidative stress. We investigated the changes in bladder function evoked by aging and the possible benefits of melatonin treatment on age related bladder disturbances. Materials and Methods: Bladder function was assessed using cystometry in conscious, freely moving female guinea pigs. Animals were grouped according to age as young adults (4 months old) and senescents (18 to 20 months old). A group of senescent animals were treated with 2.5 mg kg(-1) day(-1) melatonin for 21 days. Results: Aging led to increased detrusor activity, as demonstrated by short micturition intervals, decreased bladder capacity and spontaneous contractions during the filling phase. During the voiding phase aged animals showed lower micturition pressures than young adults. Melatonin counteracted the cystometric changes in senescent animals and restored micturition parameters to those of young adults. Conclusions: These results show that in guinea pigs aging induces detrusor overactivity. Melatonin treatment improved age induced changes in bladder function. If similar effects can be demonstrated in humans, melatonin treatment may be a new approach to decrease the impact of age related bladder disorders. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aging, bladder, urination disorders, guinea pigs, melatonin
in
Journal of Urology
volume
177
issue
4
pages
1558 - 1561
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000245090600088
  • scopus:33947225107
ISSN
1527-3792
DOI
10.1016/j.juro.2006.11.071
language
English
LU publication?
yes
id
d7b5ea7e-5865-4fe0-b2fc-775260447ce8 (old id 669615)
date added to LUP
2007-12-10 15:50:13
date last changed
2017-01-01 07:07:18
@article{d7b5ea7e-5865-4fe0-b2fc-775260447ce8,
  abstract     = {Purpose: The incidence of urinary incontinence increases with age but the cause and effect relationship between aging and altered bladder function is poorly understood. It was suggested that melatonin can ameliorate negative effects induced by aging by its free radical scavenging activity and its ability to decrease oxidative stress. We investigated the changes in bladder function evoked by aging and the possible benefits of melatonin treatment on age related bladder disturbances. Materials and Methods: Bladder function was assessed using cystometry in conscious, freely moving female guinea pigs. Animals were grouped according to age as young adults (4 months old) and senescents (18 to 20 months old). A group of senescent animals were treated with 2.5 mg kg(-1) day(-1) melatonin for 21 days. Results: Aging led to increased detrusor activity, as demonstrated by short micturition intervals, decreased bladder capacity and spontaneous contractions during the filling phase. During the voiding phase aged animals showed lower micturition pressures than young adults. Melatonin counteracted the cystometric changes in senescent animals and restored micturition parameters to those of young adults. Conclusions: These results show that in guinea pigs aging induces detrusor overactivity. Melatonin treatment improved age induced changes in bladder function. If similar effects can be demonstrated in humans, melatonin treatment may be a new approach to decrease the impact of age related bladder disorders.},
  author       = {Gomez-Pinilla, Pedro J. and Gomez, Maria and Hedlund, Petter and Swärd, Karl and Hellstrand, Per and Camello, Pedro J. and Pozo, Maria J. and Andersson, Karl-Erik},
  issn         = {1527-3792},
  keyword      = {aging,bladder,urination disorders,guinea pigs,melatonin},
  language     = {eng},
  number       = {4},
  pages        = {1558--1561},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Urology},
  title        = {Effect of melatonin on age associated changes in guinea pig bladder function},
  url          = {http://dx.doi.org/10.1016/j.juro.2006.11.071},
  volume       = {177},
  year         = {2007},
}