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Effects of L-alanyl-L-glutamine dipeptide administration during 35 days of postnatal life on intestinal mucosa, bone properties, and performance of piglets in their early post-weaning period

Pawlowska, Marta; Piedra, Jose Luis Valverde; Filip, Rafal; Szymanczyk, Sylwia Edyta; Kapica, Malgorzata; Puzio, Iwona; Skrzypek, Henryk; Gawron, Antoni; Pierzynowski, Stefan LU and Studzinski, Tadeusz (2007) In Bulletin of the Veterinary Institute in Puławy 51(1). p.125-129
Abstract
The experiment was performed on piglets, divided into control and experimental groups The experimental group received orally, from the birth to the 35(th) d of life, 0.4 g/kg b.w./d of L-alanyl-L-glutamine dipeptide (Ala-Gln). One week after weaning the piglets were killed and the small intestine and bones were sampled for histological analyses. Measurements of bone physical and geometric properties were performed according to Ferreti method. The mineral density was analysed by the DEXA method. Ala-Gln treated piglets had a higher body weight at the 35 d of age compared to that of the control piglets. Mucosa thickness, villus length, and crypt depth in the jejunum of the piglets showed higher values compared to controls. In Ala-Gln treated... (More)
The experiment was performed on piglets, divided into control and experimental groups The experimental group received orally, from the birth to the 35(th) d of life, 0.4 g/kg b.w./d of L-alanyl-L-glutamine dipeptide (Ala-Gln). One week after weaning the piglets were killed and the small intestine and bones were sampled for histological analyses. Measurements of bone physical and geometric properties were performed according to Ferreti method. The mineral density was analysed by the DEXA method. Ala-Gln treated piglets had a higher body weight at the 35 d of age compared to that of the control piglets. Mucosa thickness, villus length, and crypt depth in the jejunum of the piglets showed higher values compared to controls. In Ala-Gln treated piglets bone physical and geometric parameters and mineral density were significantly higher, and the bone structure revealed a shift in its organisation and mineralization process. In conclusion, oral administration of Ala-Gln protects the piglets from body weight loss and intestinal hypotrophy correlated with weaning and preserved the normal development of the femora during the post-weaning period. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
femur, small intestine, weaning, piglets, glutamine
in
Bulletin of the Veterinary Institute in Puławy
volume
51
issue
1
pages
125 - 129
publisher
National Veterinary Research Institute
external identifiers
  • wos:000245488100023
  • scopus:34250686071
ISSN
0042-4870
language
English
LU publication?
yes
id
daf9c9ca-8f8f-4c87-bb58-0ad256fbe487 (old id 669935)
alternative location
http://bulletin.piwet.pulawy.pl/archive/51-1/23_861_Pawlowska.pdf
date added to LUP
2007-12-14 16:20:48
date last changed
2017-01-01 07:19:10
@article{daf9c9ca-8f8f-4c87-bb58-0ad256fbe487,
  abstract     = {The experiment was performed on piglets, divided into control and experimental groups The experimental group received orally, from the birth to the 35(th) d of life, 0.4 g/kg b.w./d of L-alanyl-L-glutamine dipeptide (Ala-Gln). One week after weaning the piglets were killed and the small intestine and bones were sampled for histological analyses. Measurements of bone physical and geometric properties were performed according to Ferreti method. The mineral density was analysed by the DEXA method. Ala-Gln treated piglets had a higher body weight at the 35 d of age compared to that of the control piglets. Mucosa thickness, villus length, and crypt depth in the jejunum of the piglets showed higher values compared to controls. In Ala-Gln treated piglets bone physical and geometric parameters and mineral density were significantly higher, and the bone structure revealed a shift in its organisation and mineralization process. In conclusion, oral administration of Ala-Gln protects the piglets from body weight loss and intestinal hypotrophy correlated with weaning and preserved the normal development of the femora during the post-weaning period.},
  author       = {Pawlowska, Marta and Piedra, Jose Luis Valverde and Filip, Rafal and Szymanczyk, Sylwia Edyta and Kapica, Malgorzata and Puzio, Iwona and Skrzypek, Henryk and Gawron, Antoni and Pierzynowski, Stefan and Studzinski, Tadeusz},
  issn         = {0042-4870},
  keyword      = {femur,small intestine,weaning,piglets,glutamine},
  language     = {eng},
  number       = {1},
  pages        = {125--129},
  publisher    = {National Veterinary Research Institute},
  series       = {Bulletin of the Veterinary Institute in Puławy},
  title        = {Effects of L-alanyl-L-glutamine dipeptide administration during 35 days of postnatal life on intestinal mucosa, bone properties, and performance of piglets in their early post-weaning period},
  volume       = {51},
  year         = {2007},
}