Association between vitamin D, antimicrobial peptides and urinary tract infection in infants and young children
(2019) In Acta Paediatrica, International Journal of Paediatrics 108(3). p.551-556- Abstract
Aim: Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and β-defensin-2, which are expressed in the urinary tract. We investigated vitamin D status and levels of cathelicidin and β-defensin-2 and their association with urinary tract infection (UTI). Methods: The study included 120 children under three years of age: 76 children with UTIs and 44 otherwise healthy children with congenital hydronephrosis. Serum 25-hydroxycholecalciferol levels were measured by direct competitive electro-chemiluminescence immunoassay, and plasma cathelicidin and β-defensin-2 concentrations were analysed by enzyme-linked immunosorbent assay. Results: We found that vitamin D insufficiency and deficiency are prevalent in... (More)
Aim: Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and β-defensin-2, which are expressed in the urinary tract. We investigated vitamin D status and levels of cathelicidin and β-defensin-2 and their association with urinary tract infection (UTI). Methods: The study included 120 children under three years of age: 76 children with UTIs and 44 otherwise healthy children with congenital hydronephrosis. Serum 25-hydroxycholecalciferol levels were measured by direct competitive electro-chemiluminescence immunoassay, and plasma cathelicidin and β-defensin-2 concentrations were analysed by enzyme-linked immunosorbent assay. Results: We found that vitamin D insufficiency and deficiency are prevalent in young children (21%). Serum vitamin D levels negatively correlated with age and were significantly lower in girls. Levels of vitamin D positively correlated with levels of cathelicidin but not with β-defensin-2. Low concentrations of vitamin D were associated with UTIs in girls, but we did not see any correlation with the recurrence of infection at one-year follow-up. Conclusion: Vitamin D deficiency is common and may prove to be a risk factor for UTIs especially in girls. We hypothesise that adequate supplementation with vitamin D may become a way to prevent first-time UTIs.
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- author
- Georgieva, V. ; Kamolvit, W. ; Herthelius, M. ; Lüthje, P. ; Brauner, A. and Chromek, M. LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antimicrobial peptides, Cathelicidin, Defensin, Urinary tract infection, Vitamin D
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 108
- issue
- 3
- pages
- 551 - 556
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85052365715
- pmid:30003595
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.14499
- language
- English
- LU publication?
- yes
- id
- 66a68565-fb87-4aec-bc4c-0ae0b4e63615
- date added to LUP
- 2018-10-05 07:47:27
- date last changed
- 2024-10-15 07:40:25
@article{66a68565-fb87-4aec-bc4c-0ae0b4e63615,
abstract = {{<p>Aim: Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and β-defensin-2, which are expressed in the urinary tract. We investigated vitamin D status and levels of cathelicidin and β-defensin-2 and their association with urinary tract infection (UTI). Methods: The study included 120 children under three years of age: 76 children with UTIs and 44 otherwise healthy children with congenital hydronephrosis. Serum 25-hydroxycholecalciferol levels were measured by direct competitive electro-chemiluminescence immunoassay, and plasma cathelicidin and β-defensin-2 concentrations were analysed by enzyme-linked immunosorbent assay. Results: We found that vitamin D insufficiency and deficiency are prevalent in young children (21%). Serum vitamin D levels negatively correlated with age and were significantly lower in girls. Levels of vitamin D positively correlated with levels of cathelicidin but not with β-defensin-2. Low concentrations of vitamin D were associated with UTIs in girls, but we did not see any correlation with the recurrence of infection at one-year follow-up. Conclusion: Vitamin D deficiency is common and may prove to be a risk factor for UTIs especially in girls. We hypothesise that adequate supplementation with vitamin D may become a way to prevent first-time UTIs.</p>}},
author = {{Georgieva, V. and Kamolvit, W. and Herthelius, M. and Lüthje, P. and Brauner, A. and Chromek, M.}},
issn = {{0803-5253}},
keywords = {{Antimicrobial peptides; Cathelicidin; Defensin; Urinary tract infection; Vitamin D}},
language = {{eng}},
number = {{3}},
pages = {{551--556}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Association between vitamin D, antimicrobial peptides and urinary tract infection in infants and young children}},
url = {{http://dx.doi.org/10.1111/apa.14499}},
doi = {{10.1111/apa.14499}},
volume = {{108}},
year = {{2019}},
}