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Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants.

Pupp, Ingrid LU ; Hövel, Holger LU ; Löfqvist, Chatarina; Hellström-Westas, Lena LU ; Fellman, Vineta LU ; Hüppi, Petra S; Hellström, Ann LU and Ley, David LU (2013) In Pediatric Research 74(5). p.564-569
Abstract
Background:To evaluate the relationships between postnatal change in circulatory insulin-like growth factor I (IGF-I) concentrations, brain volumes, and developmental outcome at 2 years of age in very preterm infants.Methods:IGF-I was measured weekly and nutritional intake was calculated daily from birth until a postmenstrual age (PMA) of 35 weeks. Individual beta coefficients for IGF-I, IGF-I(B) representing rate of increase in IGF-I from birth until a PMA of 35 weeks were calculated. Brain MRI was performed at term age, with segmentation into total brain, cerebellar, gray matter and unmyelinated white matter volume (UWMV). Developmental outcome was evaluated using Bayley Scales of Infant Development-II.Results:Forty-nine infants, mean GA... (More)
Background:To evaluate the relationships between postnatal change in circulatory insulin-like growth factor I (IGF-I) concentrations, brain volumes, and developmental outcome at 2 years of age in very preterm infants.Methods:IGF-I was measured weekly and nutritional intake was calculated daily from birth until a postmenstrual age (PMA) of 35 weeks. Individual beta coefficients for IGF-I, IGF-I(B) representing rate of increase in IGF-I from birth until a PMA of 35 weeks were calculated. Brain MRI was performed at term age, with segmentation into total brain, cerebellar, gray matter and unmyelinated white matter volume (UWMV). Developmental outcome was evaluated using Bayley Scales of Infant Development-II.Results:Forty-nine infants, mean GA 26.0 weeks were evaluated at mean 24.6 months corrected age. Higher IGF-I(B), UWMV and cerebellar volume were associated with a decreased risk for a Mental Developmental Index (MDI)<85, OR(95%CI) 0.6(0.4-0.9), 0.96(0.94-0.99) and 0.78(0.6-0.96), respectively. In multivariate analysis, higher IGF-I(B) and higher UWMV combined with female gender constituted the two models with the highest predictive value for MDI>85.Conclusion:A higher rate of increase in circulating IGF-I is associated with a decreased risk for subnormal MDI at 2 years of corrected age. This relationship is in part dependent on brain volume at term age.Pediatric Research (2013); doi:10.1038/pr.2013.135. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
74
issue
5
pages
564 - 569
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000327168500011
  • pmid:23942554
  • scopus:84887471391
ISSN
1530-0447
DOI
10.1038/pr.2013.135
language
English
LU publication?
yes
id
66b3d667-85b7-4a57-8333-4177902273c7 (old id 4005747)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23942554?dopt=Abstract
date added to LUP
2013-09-04 16:34:57
date last changed
2019-08-11 03:20:22
@article{66b3d667-85b7-4a57-8333-4177902273c7,
  abstract     = {Background:To evaluate the relationships between postnatal change in circulatory insulin-like growth factor I (IGF-I) concentrations, brain volumes, and developmental outcome at 2 years of age in very preterm infants.Methods:IGF-I was measured weekly and nutritional intake was calculated daily from birth until a postmenstrual age (PMA) of 35 weeks. Individual beta coefficients for IGF-I, IGF-I(B) representing rate of increase in IGF-I from birth until a PMA of 35 weeks were calculated. Brain MRI was performed at term age, with segmentation into total brain, cerebellar, gray matter and unmyelinated white matter volume (UWMV). Developmental outcome was evaluated using Bayley Scales of Infant Development-II.Results:Forty-nine infants, mean GA 26.0 weeks were evaluated at mean 24.6 months corrected age. Higher IGF-I(B), UWMV and cerebellar volume were associated with a decreased risk for a Mental Developmental Index (MDI)&lt;85, OR(95%CI) 0.6(0.4-0.9), 0.96(0.94-0.99) and 0.78(0.6-0.96), respectively. In multivariate analysis, higher IGF-I(B) and higher UWMV combined with female gender constituted the two models with the highest predictive value for MDI&gt;85.Conclusion:A higher rate of increase in circulating IGF-I is associated with a decreased risk for subnormal MDI at 2 years of corrected age. This relationship is in part dependent on brain volume at term age.Pediatric Research (2013); doi:10.1038/pr.2013.135.},
  author       = {Pupp, Ingrid and Hövel, Holger and Löfqvist, Chatarina and Hellström-Westas, Lena and Fellman, Vineta and Hüppi, Petra S and Hellström, Ann and Ley, David},
  issn         = {1530-0447},
  language     = {eng},
  number       = {5},
  pages        = {564--569},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants.},
  url          = {http://dx.doi.org/10.1038/pr.2013.135},
  volume       = {74},
  year         = {2013},
}