Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis : A multinational study
(2021) In Rheumatology 60(10). p.4654-4661- Abstract
Objective: To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods: Patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation were included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, were collected retrospectively from tertiary vasculitis centres. Univariate and multivariate regression models were used to estimate odds ratios (ORs) and 95% CIs. Results: Over a median follow-up of 63 (interquartile range: 29, 101) months, VTE occurred in 278 (9.7%) of 2869 AAV... (More)
Objective: To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods: Patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation were included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, were collected retrospectively from tertiary vasculitis centres. Univariate and multivariate regression models were used to estimate odds ratios (ORs) and 95% CIs. Results: Over a median follow-up of 63 (interquartile range: 29, 101) months, VTE occurred in 278 (9.7%) of 2869 AAV patients with a similar frequency across different countries (from 6.3% to 13.7%), and AAV subtype [granulomatosis with polyangiitis: 9.8% (95% CI: 8.3, 11.6%); microscopic polyangiitis: 9.6% (95% CI: 7.9, 11.4%); and eosinophilic granulomatosis with polyangiitis: 9.8% (95% CI: 7.0, 13.3%)]. Most VTE (65.6%) were reported in the first-year post-diagnosis. Multiple factor logistic regression analysis adjusted for sex and age showed that skin (OR 1.71, 95% CI: 1.01, 2.92), pulmonary (OR 1.78, 95% CI: 1.04, 3.14) and kidney [eGFR 15-60 ml/min/1.73 m2, OR 2.86 (95% CI: 1.27, 6.47); eGFR <15 ml/min/1.73 m2, OR 6.71 (95% CI: 2.94, 15.33)] involvement were independent variables associated with a higher occurrence of VTE. Conclusion: Two-thirds of VTE occurred during the initial phase of active disease. We confirmed previous findings from smaller studies that a decrease in kidney function, skin involvement and pulmonary disease are independently associated with VTE.
(Less)
- author
- organization
- publishing date
- 2021-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ANCA-associated vasculitis, Risk factors, Venous thromboembolic events
- in
- Rheumatology
- volume
- 60
- issue
- 10
- pages
- 8 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:33523099
- scopus:85105571580
- ISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/keab071
- language
- English
- LU publication?
- yes
- id
- 66cd520d-2b0f-4bc2-b90a-233977cccf1b
- date added to LUP
- 2022-02-23 09:32:27
- date last changed
- 2024-04-18 06:00:25
@article{66cd520d-2b0f-4bc2-b90a-233977cccf1b,
abstract = {{<p>Objective: To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods: Patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation were included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, were collected retrospectively from tertiary vasculitis centres. Univariate and multivariate regression models were used to estimate odds ratios (ORs) and 95% CIs. Results: Over a median follow-up of 63 (interquartile range: 29, 101) months, VTE occurred in 278 (9.7%) of 2869 AAV patients with a similar frequency across different countries (from 6.3% to 13.7%), and AAV subtype [granulomatosis with polyangiitis: 9.8% (95% CI: 8.3, 11.6%); microscopic polyangiitis: 9.6% (95% CI: 7.9, 11.4%); and eosinophilic granulomatosis with polyangiitis: 9.8% (95% CI: 7.0, 13.3%)]. Most VTE (65.6%) were reported in the first-year post-diagnosis. Multiple factor logistic regression analysis adjusted for sex and age showed that skin (OR 1.71, 95% CI: 1.01, 2.92), pulmonary (OR 1.78, 95% CI: 1.04, 3.14) and kidney [eGFR 15-60 ml/min/1.73 m2, OR 2.86 (95% CI: 1.27, 6.47); eGFR <15 ml/min/1.73 m2, OR 6.71 (95% CI: 2.94, 15.33)] involvement were independent variables associated with a higher occurrence of VTE. Conclusion: Two-thirds of VTE occurred during the initial phase of active disease. We confirmed previous findings from smaller studies that a decrease in kidney function, skin involvement and pulmonary disease are independently associated with VTE. </p>}},
author = {{Moiseev, Sergey and Kronbichler, Andreas and Makarov, Egor and Bulanov, Nikolay and Crnogorac, Matija and Direskeneli, Haner and Galesic, Kresimir and Gazel, Ummugulsum and Geetha, Duvuru and Guillevin, Loic and Hrušková, Zdenka and Little, Mark A. and Ahmed, Adeel and McAdoo, Stephen P. and Mohammad, Aladdin J. and Moran, Sarah and Novikov, Pavel and Pusey, Charles D. and Rahmattulla, Chinar and Satrapová, Veronika and Silva, Joana and Terrier, Benjamin and Tesař, Vladimír and Westman, Kerstin and Jayne, David R.W.}},
issn = {{1462-0332}},
keywords = {{ANCA-associated vasculitis; Risk factors; Venous thromboembolic events}},
language = {{eng}},
month = {{10}},
number = {{10}},
pages = {{4654--4661}},
publisher = {{Oxford University Press}},
series = {{Rheumatology}},
title = {{Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis : A multinational study}},
url = {{http://dx.doi.org/10.1093/rheumatology/keab071}},
doi = {{10.1093/rheumatology/keab071}},
volume = {{60}},
year = {{2021}},
}