Refined control of cell stemness allowed animal evolution in the oxic realm
(2018) In Nature Ecology and Evolution 2(2). p.220-228- Abstract
Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (<1-3% O2) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell stemness nevertheless can be achieved through the action of oxygen-sensing transcription factors in oxygenated, regenerating tissue. We suggest that these hypoxia-inducible transcription factors provided animals with unprecedented control over cell stemness that allowed them to cope with fluctuating oxygen concentrations. Thus, a... (More)
Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (<1-3% O2) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell stemness nevertheless can be achieved through the action of oxygen-sensing transcription factors in oxygenated, regenerating tissue. We suggest that these hypoxia-inducible transcription factors provided animals with unprecedented control over cell stemness that allowed them to cope with fluctuating oxygen concentrations. Thus, a refinement of the cellular hypoxia-response machinery enabled cell stemness at oxic conditions and, then, animals to evolve into the oxic realm. This view on the onset of animal diversification is consistent with geological evidence and provides a new perspective on the challenges and evolution of multicellular life.
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- author
- Hammarlund, Emma U. LU ; Von Stedingk, Kristoffer LU and Påhlman, Sven LU
- organization
- publishing date
- 2018-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Ecology and Evolution
- volume
- 2
- issue
- 2
- pages
- 9 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:29348641
- scopus:85040666110
- ISSN
- 2397-334X
- DOI
- 10.1038/s41559-017-0410-5
- language
- English
- LU publication?
- yes
- id
- 66d5afd4-5d5d-4d2c-b03a-b2e462aef9e7
- date added to LUP
- 2018-01-30 07:42:31
- date last changed
- 2022-03-02 03:14:44
@article{66d5afd4-5d5d-4d2c-b03a-b2e462aef9e7, abstract = {{<p>Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (<1-3% O<sub>2</sub>) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell stemness nevertheless can be achieved through the action of oxygen-sensing transcription factors in oxygenated, regenerating tissue. We suggest that these hypoxia-inducible transcription factors provided animals with unprecedented control over cell stemness that allowed them to cope with fluctuating oxygen concentrations. Thus, a refinement of the cellular hypoxia-response machinery enabled cell stemness at oxic conditions and, then, animals to evolve into the oxic realm. This view on the onset of animal diversification is consistent with geological evidence and provides a new perspective on the challenges and evolution of multicellular life.</p>}}, author = {{Hammarlund, Emma U. and Von Stedingk, Kristoffer and Påhlman, Sven}}, issn = {{2397-334X}}, language = {{eng}}, month = {{02}}, number = {{2}}, pages = {{220--228}}, publisher = {{Nature Publishing Group}}, series = {{Nature Ecology and Evolution}}, title = {{Refined control of cell stemness allowed animal evolution in the oxic realm}}, url = {{http://dx.doi.org/10.1038/s41559-017-0410-5}}, doi = {{10.1038/s41559-017-0410-5}}, volume = {{2}}, year = {{2018}}, }