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Refined control of cell stemness allowed animal evolution in the oxic realm

Hammarlund, Emma U. LU ; Von Stedingk, Kristoffer LU and Påhlman, Sven LU (2018) In Nature Ecology and Evolution 2(2). p.220-228
Abstract

Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (<1-3% O2) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell stemness nevertheless can be achieved through the action of oxygen-sensing transcription factors in oxygenated, regenerating tissue. We suggest that these hypoxia-inducible transcription factors provided animals with unprecedented control over cell stemness that allowed them to cope with fluctuating oxygen concentrations. Thus, a... (More)

Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (<1-3% O2) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell stemness nevertheless can be achieved through the action of oxygen-sensing transcription factors in oxygenated, regenerating tissue. We suggest that these hypoxia-inducible transcription factors provided animals with unprecedented control over cell stemness that allowed them to cope with fluctuating oxygen concentrations. Thus, a refinement of the cellular hypoxia-response machinery enabled cell stemness at oxic conditions and, then, animals to evolve into the oxic realm. This view on the onset of animal diversification is consistent with geological evidence and provides a new perspective on the challenges and evolution of multicellular life.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Ecology and Evolution
volume
2
issue
2
pages
9 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85040817923
  • scopus:85040666110
DOI
10.1038/s41559-017-0410-5
language
English
LU publication?
yes
id
66d5afd4-5d5d-4d2c-b03a-b2e462aef9e7
date added to LUP
2018-01-30 07:42:31
date last changed
2018-11-21 21:37:42
@article{66d5afd4-5d5d-4d2c-b03a-b2e462aef9e7,
  abstract     = {<p>Animal diversification on Earth has long been presumed to be associated with the increasing extent of oxic niches. Here, we challenge that view. We start with the fact that hypoxia (&lt;1-3% O<sub>2</sub>) maintains cellular immaturity (stemness), whereas adult stem cells continuously - and paradoxically - regenerate animal tissue in oxygenated settings. Novel insights from tumour biology illuminate how cell stemness nevertheless can be achieved through the action of oxygen-sensing transcription factors in oxygenated, regenerating tissue. We suggest that these hypoxia-inducible transcription factors provided animals with unprecedented control over cell stemness that allowed them to cope with fluctuating oxygen concentrations. Thus, a refinement of the cellular hypoxia-response machinery enabled cell stemness at oxic conditions and, then, animals to evolve into the oxic realm. This view on the onset of animal diversification is consistent with geological evidence and provides a new perspective on the challenges and evolution of multicellular life.</p>},
  author       = {Hammarlund, Emma U. and Von Stedingk, Kristoffer and Påhlman, Sven},
  language     = {eng},
  month        = {02},
  number       = {2},
  pages        = {220--228},
  publisher    = {Nature Publishing Group},
  series       = {Nature Ecology and Evolution},
  title        = {Refined control of cell stemness allowed animal evolution in the oxic realm},
  url          = {http://dx.doi.org/10.1038/s41559-017-0410-5},
  volume       = {2},
  year         = {2018},
}