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Oxytocin levels in the posterior pituitary and in the heart are modified by voluntary wheel running

Bakos, J.; Hlavacova, N.; Makatsori, A.; Tybitanclova, K.; Zorad, S.; Hinghofer-Szalkay, H.; Johansson, Barbro LU and Jezova, D. (2007) In Regulatory Peptides 139(1-3). p.96-101
Abstract
We hypothesized that voluntary wheel running results in increased secretion of oxytocin, a peptide involved in the stress response. An additional hypothesis was that prolonged exercise affects oxytocin levels in the heart, which is in line with the potential role of oxytocin in cardiovascular functions. Voluntary wheel running lasted 3 weeks and daily running distances increased progressively reaching maximum levels about 8 km (Sprague-Dawley rats) and 4 km (Lewis strain). The exercise resulted in significant reduction of epididymal fat, slight increase in glucose transporter GLUT4 mRNA levels and significant enhancement of plasma density. Voluntary exercise failed to influence plasma oxytocin levels either in Lewis or Sprague-Dawley rats,... (More)
We hypothesized that voluntary wheel running results in increased secretion of oxytocin, a peptide involved in the stress response. An additional hypothesis was that prolonged exercise affects oxytocin levels in the heart, which is in line with the potential role of oxytocin in cardiovascular functions. Voluntary wheel running lasted 3 weeks and daily running distances increased progressively reaching maximum levels about 8 km (Sprague-Dawley rats) and 4 km (Lewis strain). The exercise resulted in significant reduction of epididymal fat, slight increase in glucose transporter GLUT4 mRNA levels and significant enhancement of plasma density. Voluntary exercise failed to influence plasma oxytocin levels either in Lewis or Sprague-Dawley rats, but it resulted in a significant decrease of oxytocin concentrations in the posterior pituitary. Plasma oxytocin concentrations were not modified even if the measurements were made in the dark phase of the day. In voluntary wheel running Sprague-Dawley rats, the content of oxytocin in the right heart atrium was lower than in controls. Thus, the present findings demonstrate that prolonged voluntary wheel running results in a decrease in pituitary oxytocin content without evident changes in hormone concentrations in peripheral blood. However, prolonged exercise used has a significant impact on oxytocin levels in the heart. (c) 2006 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular system, exercise, neuropeptide, rat
in
Regulatory Peptides
volume
139
issue
1-3
pages
96 - 101
publisher
Elsevier
external identifiers
  • wos:000244767000014
  • scopus:33846849576
ISSN
1873-1686
DOI
10.1016/j.regpep.2006.10.011
language
English
LU publication?
yes
id
b88a184e-2033-4f7b-9b4f-da416474aefb (old id 670364)
date added to LUP
2007-12-05 08:31:40
date last changed
2017-07-30 03:48:27
@article{b88a184e-2033-4f7b-9b4f-da416474aefb,
  abstract     = {We hypothesized that voluntary wheel running results in increased secretion of oxytocin, a peptide involved in the stress response. An additional hypothesis was that prolonged exercise affects oxytocin levels in the heart, which is in line with the potential role of oxytocin in cardiovascular functions. Voluntary wheel running lasted 3 weeks and daily running distances increased progressively reaching maximum levels about 8 km (Sprague-Dawley rats) and 4 km (Lewis strain). The exercise resulted in significant reduction of epididymal fat, slight increase in glucose transporter GLUT4 mRNA levels and significant enhancement of plasma density. Voluntary exercise failed to influence plasma oxytocin levels either in Lewis or Sprague-Dawley rats, but it resulted in a significant decrease of oxytocin concentrations in the posterior pituitary. Plasma oxytocin concentrations were not modified even if the measurements were made in the dark phase of the day. In voluntary wheel running Sprague-Dawley rats, the content of oxytocin in the right heart atrium was lower than in controls. Thus, the present findings demonstrate that prolonged voluntary wheel running results in a decrease in pituitary oxytocin content without evident changes in hormone concentrations in peripheral blood. However, prolonged exercise used has a significant impact on oxytocin levels in the heart. (c) 2006 Elsevier B.V. All rights reserved.},
  author       = {Bakos, J. and Hlavacova, N. and Makatsori, A. and Tybitanclova, K. and Zorad, S. and Hinghofer-Szalkay, H. and Johansson, Barbro and Jezova, D.},
  issn         = {1873-1686},
  keyword      = {cardiovascular system,exercise,neuropeptide,rat},
  language     = {eng},
  number       = {1-3},
  pages        = {96--101},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Oxytocin levels in the posterior pituitary and in the heart are modified by voluntary wheel running},
  url          = {http://dx.doi.org/10.1016/j.regpep.2006.10.011},
  volume       = {139},
  year         = {2007},
}