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Innate lymphoid cells in atherosclerosis

Engelbertsen, Daniel LU and Lichtman, Andrew H (2017) In European Journal of Pharmacology 816. p.32-36
Abstract

The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of... (More)

The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Atherosclerosis/immunology, Humans, Immunity, Innate, Lymphocytes/cytology
in
European Journal of Pharmacology
volume
816
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85019112535
ISSN
1879-0712
DOI
10.1016/j.ejphar.2017.04.030
language
English
LU publication?
no
id
670f69ed-9879-415a-bd5a-4f50690befd7
date added to LUP
2019-01-16 10:12:09
date last changed
2019-09-17 04:47:05
@article{670f69ed-9879-415a-bd5a-4f50690befd7,
  abstract     = {<p>The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions. ILC1s produce IFN-γ upon stimulation with IL-12 and IL-18, ILC2s produce IL-5 and IL-13 responding to IL-33 and IL-25 while ILC3s produce IL-17 and IL-22 after stimulation with IL-23 or IL-1. Although few studies have directly investigated the role for ILCs in atherosclerosis, several studies have investigated transcription factors and cytokines shared by ILCs and T helper cells. In this review we summarize our current understanding of the role of ILC in atherosclerosis and discuss future directions.</p>},
  author       = {Engelbertsen, Daniel and Lichtman, Andrew H},
  issn         = {1879-0712},
  keyword      = {Animals,Atherosclerosis/immunology,Humans,Immunity, Innate,Lymphocytes/cytology},
  language     = {eng},
  month        = {12},
  pages        = {32--36},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Innate lymphoid cells in atherosclerosis},
  url          = {http://dx.doi.org/10.1016/j.ejphar.2017.04.030},
  volume       = {816},
  year         = {2017},
}