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Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction

Youssef, Lina LU orcid ; Erlandsson, Lena LU ; Åkerström, Bo LU ; Miranda, Jezid ; Paules, Cristina ; Crovetto, Francesca ; Crispi, Fatima ; Gratacos, Eduard and Hansson, Stefan R. LU orcid (2020) In PLoS ONE 15(9 September).
Abstract

Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n = 49). Samples were collected at delivery and ELISA analysis was applied to measure the hemopexin and α1-microglobulin concentrations. In maternal blood in preeclampsia with and without FGR, hemopexin was significantly lower... (More)

Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n = 49). Samples were collected at delivery and ELISA analysis was applied to measure the hemopexin and α1-microglobulin concentrations. In maternal blood in preeclampsia with and without FGR, hemopexin was significantly lower (p = 0.003 and p<0.001, respectively) and α1-microglobulin was significantly higher (p<0.001 in both) whereas no difference existed in normotensive FGR mothers compared to controls. In contrast, in fetal blood in growth restricted fetuses with and without preeclampsia, both hemopexin and α1-microglobulin were significantly lower (p<0.001 and p = 0.001 for hemopexin, p = 0.016 and p = 0.013 for α1-microglobulin, respectively) with no difference in fetuses from preeclampsia without FGR in comparison to controls. Thus, hemopexin and α1-microglobulin present significantly altered concentrations in maternal blood in the maternal disease -preeclampsia- and in cord blood in the fetal disease -FGR-, which supports their differential role in placenta-mediated disorders in accordance with the clinical presentation of these disorders.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
15
issue
9 September
article number
e0239030
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:32915914
  • scopus:85090846723
ISSN
1932-6203
DOI
10.1371/journal.pone.0239030
language
English
LU publication?
yes
id
6723926d-abdc-4a26-adc4-d6b5b842e87d
date added to LUP
2020-09-30 10:21:56
date last changed
2022-08-11 17:00:21
@article{6723926d-abdc-4a26-adc4-d6b5b842e87d,
  abstract     = {{<p>Hemopexin and α<sub>1</sub>-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n = 49). Samples were collected at delivery and ELISA analysis was applied to measure the hemopexin and α<sub>1</sub>-microglobulin concentrations. In maternal blood in preeclampsia with and without FGR, hemopexin was significantly lower (p = 0.003 and p&lt;0.001, respectively) and α<sub>1</sub>-microglobulin was significantly higher (p&lt;0.001 in both) whereas no difference existed in normotensive FGR mothers compared to controls. In contrast, in fetal blood in growth restricted fetuses with and without preeclampsia, both hemopexin and α<sub>1</sub>-microglobulin were significantly lower (p&lt;0.001 and p = 0.001 for hemopexin, p = 0.016 and p = 0.013 for α<sub>1</sub>-microglobulin, respectively) with no difference in fetuses from preeclampsia without FGR in comparison to controls. Thus, hemopexin and α<sub>1</sub>-microglobulin present significantly altered concentrations in maternal blood in the maternal disease -preeclampsia- and in cord blood in the fetal disease -FGR-, which supports their differential role in placenta-mediated disorders in accordance with the clinical presentation of these disorders.</p>}},
  author       = {{Youssef, Lina and Erlandsson, Lena and Åkerström, Bo and Miranda, Jezid and Paules, Cristina and Crovetto, Francesca and Crispi, Fatima and Gratacos, Eduard and Hansson, Stefan R.}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{9 September}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Hemopexin and α<sub>1</sub>-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0239030}},
  doi          = {{10.1371/journal.pone.0239030}},
  volume       = {{15}},
  year         = {{2020}},
}