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Chip integrated strategies for acoustic separation and manipulation of cells and particles

Laurell, Thomas LU ; Petersson, Filip LU and Lenshof, Andreas LU (2007) In Chemical Society Reviews 36(3). p.492-506
Abstract
Acoustic standing wave technology combined with microtechnology opens up new areas for the development of advanced particle and cell separating microfluidic systems. This tutorial review outlines the fundamental work performed on continuous flow acoustic standing wave separation of particles in macro scale systems. The transition to the microchip format is further surveyed, where both fabrication and design issues are discussed. The acoustic technology offers attractive features, such as reasonable throughput and ability to separate particles in a size domain of about tenths of micrometers to tens of micrometers. Examples of different particle separation modes enabled in microfluidic chips, utilizing standing wave technology, are described... (More)
Acoustic standing wave technology combined with microtechnology opens up new areas for the development of advanced particle and cell separating microfluidic systems. This tutorial review outlines the fundamental work performed on continuous flow acoustic standing wave separation of particles in macro scale systems. The transition to the microchip format is further surveyed, where both fabrication and design issues are discussed. The acoustic technology offers attractive features, such as reasonable throughput and ability to separate particles in a size domain of about tenths of micrometers to tens of micrometers. Examples of different particle separation modes enabled in microfluidic chips, utilizing standing wave technology, are described along a discussion of several potential applications in life science research and in the medical clinic. Chip integrated acoustic standing wave separation technology is still in its infancy and it can be anticipated that new laboratory standards very well may emerge from the current research. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemical Society Reviews
volume
36
issue
3
pages
492 - 506
publisher
Royal Society of Chemistry
external identifiers
  • wos:000244497700005
  • scopus:33847326950
ISSN
0306-0012
DOI
10.1039/b601326k
language
English
LU publication?
yes
id
ded91501-5ca6-461c-8612-bf9d62d1b9ed (old id 673937)
date added to LUP
2007-12-12 13:24:58
date last changed
2017-11-05 03:28:36
@article{ded91501-5ca6-461c-8612-bf9d62d1b9ed,
  abstract     = {Acoustic standing wave technology combined with microtechnology opens up new areas for the development of advanced particle and cell separating microfluidic systems. This tutorial review outlines the fundamental work performed on continuous flow acoustic standing wave separation of particles in macro scale systems. The transition to the microchip format is further surveyed, where both fabrication and design issues are discussed. The acoustic technology offers attractive features, such as reasonable throughput and ability to separate particles in a size domain of about tenths of micrometers to tens of micrometers. Examples of different particle separation modes enabled in microfluidic chips, utilizing standing wave technology, are described along a discussion of several potential applications in life science research and in the medical clinic. Chip integrated acoustic standing wave separation technology is still in its infancy and it can be anticipated that new laboratory standards very well may emerge from the current research.},
  author       = {Laurell, Thomas and Petersson, Filip and Lenshof, Andreas},
  issn         = {0306-0012},
  language     = {eng},
  number       = {3},
  pages        = {492--506},
  publisher    = {Royal Society of Chemistry},
  series       = {Chemical Society Reviews},
  title        = {Chip integrated strategies for acoustic separation and manipulation of cells and particles},
  url          = {http://dx.doi.org/10.1039/b601326k},
  volume       = {36},
  year         = {2007},
}