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The continuing role of PSA in the detection and management of prostate cancer

Miller, Kurt ; Abrahamsson, Per-Anders LU ; Akakura, Koichiro ; Debruyne, Frans M. J. ; Evans, Christopher P. and Klotz, Laurence (2007) In European Urology. Supplement 6(3). p.327-333
Abstract
Despite being used extensively for the diagnosis and management of prostate cancer, prostate-specific antigen (PSA) testing remains controversial. Doubts have been raised over the continued use of PSA in the detection of clinically significant prostate cancer because many men now present with early-stage, small-volume tumours. This article examines the limitations of using a single PSA value in diagnosis and discusses alternative approaches to PSA testing, in particular PSA velocity and PSA doubling time, which are now emerging as valuable pretreatment disease predictors. A clinical scenario is also presented to illustrate the use of PSA kinetics in identifying candidates for biopsy. (c) 2006 European Association of Urology. Published by... (More)
Despite being used extensively for the diagnosis and management of prostate cancer, prostate-specific antigen (PSA) testing remains controversial. Doubts have been raised over the continued use of PSA in the detection of clinically significant prostate cancer because many men now present with early-stage, small-volume tumours. This article examines the limitations of using a single PSA value in diagnosis and discusses alternative approaches to PSA testing, in particular PSA velocity and PSA doubling time, which are now emerging as valuable pretreatment disease predictors. A clinical scenario is also presented to illustrate the use of PSA kinetics in identifying candidates for biopsy. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PSA doubling time, prostate cancer, PSA, PSA velocity
in
European Urology. Supplement
volume
6
issue
3
pages
327 - 333
publisher
Elsevier
external identifiers
  • wos:000244379300002
  • scopus:33846408703
ISSN
1569-9056
DOI
10.1016/j.eursup.2006.12.001
language
English
LU publication?
yes
id
76e9754f-1af2-43ae-9b10-96ef2e4cd0c9 (old id 674200)
date added to LUP
2016-04-01 17:04:59
date last changed
2022-03-22 23:12:22
@article{76e9754f-1af2-43ae-9b10-96ef2e4cd0c9,
  abstract     = {{Despite being used extensively for the diagnosis and management of prostate cancer, prostate-specific antigen (PSA) testing remains controversial. Doubts have been raised over the continued use of PSA in the detection of clinically significant prostate cancer because many men now present with early-stage, small-volume tumours. This article examines the limitations of using a single PSA value in diagnosis and discusses alternative approaches to PSA testing, in particular PSA velocity and PSA doubling time, which are now emerging as valuable pretreatment disease predictors. A clinical scenario is also presented to illustrate the use of PSA kinetics in identifying candidates for biopsy. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved.}},
  author       = {{Miller, Kurt and Abrahamsson, Per-Anders and Akakura, Koichiro and Debruyne, Frans M. J. and Evans, Christopher P. and Klotz, Laurence}},
  issn         = {{1569-9056}},
  keywords     = {{PSA doubling time; prostate cancer; PSA; PSA velocity}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{327--333}},
  publisher    = {{Elsevier}},
  series       = {{European Urology. Supplement}},
  title        = {{The continuing role of PSA in the detection and management of prostate cancer}},
  url          = {{http://dx.doi.org/10.1016/j.eursup.2006.12.001}},
  doi          = {{10.1016/j.eursup.2006.12.001}},
  volume       = {{6}},
  year         = {{2007}},
}