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Strategies for the introduction of human papillomavirus vaccination: modelling the optimum age- and sex-specific pattern of vaccination in Finland

French, K M; Barnabas, R V; Lehtinen, M; Kontula, O; Pukkala, E; Dillner, Joakim LU and Garnett, G P (2007) In British Journal of Cancer 96(3). p.514-518
Abstract
Phase III trials have demonstrated the efficacy of human papillomavirus (HPV) vaccines in preventing transient and persistent high-risk (hr) HPV infection and precancerous lesions. A mathematical model of HPV type 16 infection and progression to cervical cancer, parameterised to represent the infection in Finland, was used to explore the optimal age at vaccination and pattern of vaccine introduction. In the long term, the annual proportion of cervical cancer cases prevented is much higher when early adolescents are targeted. Vaccinating against hr HPV generates greater long-term benefits if vaccine is delivered before the age at first sexual intercourse. However, vaccinating 12 year olds delays the predicted decrease in cervical cancer,... (More)
Phase III trials have demonstrated the efficacy of human papillomavirus (HPV) vaccines in preventing transient and persistent high-risk (hr) HPV infection and precancerous lesions. A mathematical model of HPV type 16 infection and progression to cervical cancer, parameterised to represent the infection in Finland, was used to explore the optimal age at vaccination and pattern of vaccine introduction. In the long term, the annual proportion of cervical cancer cases prevented is much higher when early adolescents are targeted. Vaccinating against hr HPV generates greater long-term benefits if vaccine is delivered before the age at first sexual intercourse. However, vaccinating 12 year olds delays the predicted decrease in cervical cancer, compared to vaccinating older adolescents or young adults. Vaccinating males as well as females has more impact on the proportion of cases prevented when vaccinating at younger ages. Implementing catch-up vaccination at the start of a vaccination programme would increase the speed with which a decrease in HPV and cervical cancer incidence is observed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
modelling, HPV, vaccination
in
British Journal of Cancer
volume
96
issue
3
pages
514 - 518
publisher
Nature Publishing Group
external identifiers
  • wos:000244100300018
  • scopus:33846786650
ISSN
1532-1827
DOI
10.1038/sj.bjc.6603575
language
English
LU publication?
yes
id
9f04c3bf-9d68-4d11-a5ff-d5704b4098d0 (old id 674779)
date added to LUP
2007-12-07 10:52:54
date last changed
2017-05-28 03:40:18
@article{9f04c3bf-9d68-4d11-a5ff-d5704b4098d0,
  abstract     = {Phase III trials have demonstrated the efficacy of human papillomavirus (HPV) vaccines in preventing transient and persistent high-risk (hr) HPV infection and precancerous lesions. A mathematical model of HPV type 16 infection and progression to cervical cancer, parameterised to represent the infection in Finland, was used to explore the optimal age at vaccination and pattern of vaccine introduction. In the long term, the annual proportion of cervical cancer cases prevented is much higher when early adolescents are targeted. Vaccinating against hr HPV generates greater long-term benefits if vaccine is delivered before the age at first sexual intercourse. However, vaccinating 12 year olds delays the predicted decrease in cervical cancer, compared to vaccinating older adolescents or young adults. Vaccinating males as well as females has more impact on the proportion of cases prevented when vaccinating at younger ages. Implementing catch-up vaccination at the start of a vaccination programme would increase the speed with which a decrease in HPV and cervical cancer incidence is observed.},
  author       = {French, K M and Barnabas, R V and Lehtinen, M and Kontula, O and Pukkala, E and Dillner, Joakim and Garnett, G P},
  issn         = {1532-1827},
  keyword      = {modelling,HPV,vaccination},
  language     = {eng},
  number       = {3},
  pages        = {514--518},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Strategies for the introduction of human papillomavirus vaccination: modelling the optimum age- and sex-specific pattern of vaccination in Finland},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6603575},
  volume       = {96},
  year         = {2007},
}