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Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance

Nilsson, Kent W.; Damberg, Mattias; Ohrvik, John; Leppert, Jerzy; Lindstrom, Leif; Anckarsäter, Henrik LU and Oreland, Lars (2007) In Neuroscience Letters 411(3). p.233-237
Abstract
In several twin studies the relative contribution of genetic factors for personality traits has amounted to figures between 40 and 60%. In the present study we investigated to which degree polymorphisms in the 5-HTT and AP-2 beta genes are implicated in the neural processes involved in the formation of Temperament and Character traits, as estimated by Cloninger's TCI. Considering the background of previous reports, associations with the character Self-Transcendence and its sub-scale Spiritual Acceptance in particular, were of interest. A stratified random sample of 200 individuals (total population = 5173), matched for age, gender and risk behaviors, from volunteering 16- and 19-year-old adolescents students in Sweden was investigated.... (More)
In several twin studies the relative contribution of genetic factors for personality traits has amounted to figures between 40 and 60%. In the present study we investigated to which degree polymorphisms in the 5-HTT and AP-2 beta genes are implicated in the neural processes involved in the formation of Temperament and Character traits, as estimated by Cloninger's TCI. Considering the background of previous reports, associations with the character Self-Transcendence and its sub-scale Spiritual Acceptance in particular, were of interest. A stratified random sample of 200 individuals (total population = 5173), matched for age, gender and risk behaviors, from volunteering 16- and 19-year-old adolescents students in Sweden was investigated. Cloninger's TCI inventory was used for investigation of temperament and character traits. Blood samples were used for analyses of a promoter serotonin transporter polymorphism (5-HTTLPR) and an intron 2 polymorphism in the transcription factor AP-2 beta gene. Among boys individuals with presence of the short 5-HTTLPR genotype showed lower scores, whereas individuals with presence of the short AP-2 beta genotype showed higher scores of personality character Self-Transcendence and its sub-scale Spiritual Acceptance. Among girls no effect of either genotype was found. Both among boys and girls, significant interactive effects were found between 5-HTTLPR and AP-2 beta genotypes, with regard to Self-Transcendence and Spiritual acceptance. Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2 beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance. (c) 2006 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transcription, factor AP-2, serotonin, adolescent, personality, spirituality, genes
in
Neuroscience Letters
volume
411
issue
3
pages
233 - 237
publisher
Elsevier
external identifiers
  • wos:000244078300014
  • scopus:37849189263
ISSN
0304-3940
DOI
10.1016/j.neulet.2006.10.051
language
English
LU publication?
yes
id
ea976208-8fbb-4e45-b2a5-a17bb4d6429d (old id 675001)
date added to LUP
2007-12-14 08:35:01
date last changed
2017-10-22 03:34:17
@article{ea976208-8fbb-4e45-b2a5-a17bb4d6429d,
  abstract     = {In several twin studies the relative contribution of genetic factors for personality traits has amounted to figures between 40 and 60%. In the present study we investigated to which degree polymorphisms in the 5-HTT and AP-2 beta genes are implicated in the neural processes involved in the formation of Temperament and Character traits, as estimated by Cloninger's TCI. Considering the background of previous reports, associations with the character Self-Transcendence and its sub-scale Spiritual Acceptance in particular, were of interest. A stratified random sample of 200 individuals (total population = 5173), matched for age, gender and risk behaviors, from volunteering 16- and 19-year-old adolescents students in Sweden was investigated. Cloninger's TCI inventory was used for investigation of temperament and character traits. Blood samples were used for analyses of a promoter serotonin transporter polymorphism (5-HTTLPR) and an intron 2 polymorphism in the transcription factor AP-2 beta gene. Among boys individuals with presence of the short 5-HTTLPR genotype showed lower scores, whereas individuals with presence of the short AP-2 beta genotype showed higher scores of personality character Self-Transcendence and its sub-scale Spiritual Acceptance. Among girls no effect of either genotype was found. Both among boys and girls, significant interactive effects were found between 5-HTTLPR and AP-2 beta genotypes, with regard to Self-Transcendence and Spiritual acceptance. Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2 beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance. (c) 2006 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Nilsson, Kent W. and Damberg, Mattias and Ohrvik, John and Leppert, Jerzy and Lindstrom, Leif and Anckarsäter, Henrik and Oreland, Lars},
  issn         = {0304-3940},
  keyword      = {transcription,factor AP-2,serotonin,adolescent,personality,spirituality,genes},
  language     = {eng},
  number       = {3},
  pages        = {233--237},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Genes encoding for AP-2 beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance},
  url          = {http://dx.doi.org/10.1016/j.neulet.2006.10.051},
  volume       = {411},
  year         = {2007},
}