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Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus - An international inception cohort study

Hanly, J. G.; Urowitz, M. B.; Sanchez-Guerrero, J.; Bae, S. C.; Gordon, C.; Wallace, D. J.; Isenberg, D.; Alarcon, G. S.; Clarke, A. and Bernatsky, S., et al. (2007) In Arthritis and Rheumatism 56(1). p.265-273
Abstract
Objective. To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. Methods. The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR... (More)
Objective. To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. Methods. The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR Damage Index (SDI). Results. A total of 572 patients (88% female) were recruited, with a mean +/- SD age of 35 +/- 14 years. The mean +/- SD disease duration was 5.2 +/- 4.2 months. Within the enrollment window, 158 of 572 patients (28%) had at least 1 NP event. In total, there were 242 NP events that encompassed 15 of 19 NP syndromes. The proportion of NP events attributed to SLE varied from 19% to 38% using alternate attribution models and occurred in 6.1-11.7% of patients. Those with NP events, regardless of attribution, had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events. Conclusion. Twenty-eight percent of SLE patients experienced at least 1 NP event around the time of diagnosis of SLE, of which only a minority were attributed to SLE. Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage. (Less)
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published
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Arthritis and Rheumatism
volume
56
issue
1
pages
265 - 273
publisher
John Wiley & Sons
external identifiers
  • wos:000243395900031
  • scopus:33846213107
ISSN
1529-0131
DOI
10.1002/art.22305
language
English
LU publication?
yes
id
ab474e7e-c459-4817-8bbf-67d5a895b7ab (old id 679771)
date added to LUP
2007-12-12 11:12:46
date last changed
2017-11-05 03:47:05
@article{ab474e7e-c459-4817-8bbf-67d5a895b7ab,
  abstract     = {Objective. To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. Methods. The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR Damage Index (SDI). Results. A total of 572 patients (88% female) were recruited, with a mean +/- SD age of 35 +/- 14 years. The mean +/- SD disease duration was 5.2 +/- 4.2 months. Within the enrollment window, 158 of 572 patients (28%) had at least 1 NP event. In total, there were 242 NP events that encompassed 15 of 19 NP syndromes. The proportion of NP events attributed to SLE varied from 19% to 38% using alternate attribution models and occurred in 6.1-11.7% of patients. Those with NP events, regardless of attribution, had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events. Conclusion. Twenty-eight percent of SLE patients experienced at least 1 NP event around the time of diagnosis of SLE, of which only a minority were attributed to SLE. Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage.},
  author       = {Hanly, J. G. and Urowitz, M. B. and Sanchez-Guerrero, J. and Bae, S. C. and Gordon, C. and Wallace, D. J. and Isenberg, D. and Alarcon, G. S. and Clarke, A. and Bernatsky, S. and Merrill, J. T. and Petri, M. and Dooley, M. A. and Gladman, D. and Fortin, P. R. and Steinsson, K. and Bruce, I. and Manzi, S. and Khamashta, M. and Zoma, A. and Aranow, C. and Ginzler, E. and Van Vollenhoven, R. and Font, J. and Sturfelt, Gunnar and Nived, Ola and Ramsey-Goldman, R. and Kalunian, K. and Douglas, J. and Thompson, K. and Farewell, V.},
  issn         = {1529-0131},
  language     = {eng},
  number       = {1},
  pages        = {265--273},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis and Rheumatism},
  title        = {Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus - An international inception cohort study},
  url          = {http://dx.doi.org/10.1002/art.22305},
  volume       = {56},
  year         = {2007},
}